Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gilchrist JJ"'
Autor:
Gilchrist, JJ, MacLennan, CA
Publikováno v:
Medicine. 49:595-602
The human immune system is composed of a collection of specialized cells and secreted proteins that allows the identification and removal of an invading pathogen, and in doing so limits host injury or death. This system is composed of innate and adap
Autor:
Gilchrist, JJ, Kariuki, SN, Watson, JA, Band, G, Uyoga, S, Ndila, CM, Mturi, N, Mwarumba, S, Mohammed, S, Mosobo, M, Alasoo, K, Rockett, KA, Mentzer, AJ, Kwiatkowski, DP, Hill, AVS, Maitland, K, Scott, JAG, Williams, TN
Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12a6766bb51b546c99f298525a25403
http://hdl.handle.net/10044/1/98502
http://hdl.handle.net/10044/1/98502
Autor:
Gilchrist, JJ, Rautanen, A, Fairfax, BP, Mills, TC, Naranbhai, V, Trochet, H, Pirinen, M, Muthumbi, E, Mwarumba, S, Njuguna, P, Mturi, N, Msefula, CL, Gondwe, EN, MacLennan, JM, Chapman, SJ, Molyneux, ME, Knight, JC, Spencer, CCA, Williams, TN, MacLennan, CA, Scott, JAG, Hill, AVS
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 case
In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously we showed transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e36d068fca8379a4d22eda511c3f0e60
https://ora.ox.ac.uk/objects/uuid:d8cc7fb0-426f-4b96-8c16-a6b91c906cdf
https://ora.ox.ac.uk/objects/uuid:d8cc7fb0-426f-4b96-8c16-a6b91c906cdf
Autor:
Kariuki SN; Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Gilchrist JJ; Department of Paediatrics, University of Oxford, Oxford, UK.; MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Uyoga S; Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Macharia A; Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Makale J; Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Rayner JC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Williams TN; Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College London, London, UK.
Publikováno v:
The Journal of infectious diseases [J Infect Dis] 2024 Jul 09. Date of Electronic Publication: 2024 Jul 09.
Autor:
Gilchrist JJ; Department of Paediatrics, University of Oxford, Oxford OX3 9DU, UK; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Fang H; Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Danielli S; Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Tomkova M; Ludwig Cancer Research Oxford, University of Oxford, Oxford OX3 7DQ, UK., Nassiri I; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Ng E; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Tong O; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Taylor C; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Muldoon D; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Cohen LRZ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Al-Mossawi H; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Lau E; Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Neville M; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LE, UK., Schuster-Boeckler B; Ludwig Cancer Research Oxford, University of Oxford, Oxford OX3 7DQ, UK., Knight JC; Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Fairfax BP; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Department of Oncology, University of Oxford, Oxford OX3 9DS, UK. Electronic address: benjamin.fairfax@oncology.ox.ac.uk.
Publikováno v:
Cell genomics [Cell Genom] 2024 May 08; Vol. 4 (5), pp. 100541. Date of Electronic Publication: 2024 Apr 24.
Autor:
Chong AY; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address: amanda.chong@well.ox.ac.uk., Brenner N; Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jimenez-Kaufmann A; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (LANGEBIO), CINVESTAV, Irapuato, Mexico., Cortes A; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hill M; MRC-Population Health Research Unit, University of Oxford, Oxford, UK., Littlejohns TJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Gilchrist JJ; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Department of Paediatrics, University of Oxford, Oxford, UK., Fairfax BP; Department of Oncology, University of Oxford, Oxford, UK., Knight JC; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Hodel F; Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Fellay J; Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., McVean G; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Moreno-Estrada A; Advanced Genomics Unit, National Laboratory of Genomics for Biodiversity (LANGEBIO), CINVESTAV, Irapuato, Mexico., Waterboer T; Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hill AVS; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; The Jenner Institute, University of Oxford, Oxford, UK., Mentzer AJ; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. Electronic address: alexander.mentzer@ndm.ox.ac.uk.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2024 Feb 01; Vol. 111 (2), pp. 295-308. Date of Electronic Publication: 2024 Jan 16.
Autor:
Schurz H; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Naranbhai V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Massachusetts General Hospital, Boston, United States.; Dana-Farber Cancer Institute, Boston, United States.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Harvard Medical School, Boston, United States., Yates TA; Division of Infection and Immunity, Faculty of Medical Sciences, University College London, London, United Kingdom., Gilchrist JJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Parks T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Infectious Diseases Imperial College London, London, United Kingdom., Dodd PJ; School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom., Möller M; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Hoal EG; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom., Hill AVS; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Jenner Institute, University of Oxford, Oxford, United Kingdom.
Publikováno v:
ELife [Elife] 2024 Jan 15; Vol. 13. Date of Electronic Publication: 2024 Jan 15.
Autor:
Gilchrist JJ; From the Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Hoy T; Department of Paediatric Neurosurgery, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Bijker EM; From the Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Paediatrics, Maastricht University Medical Center, Maastricht, The Netherlands., Lees EA; From the Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Fitzwilliam College, Cambridge, United Kingdom., Wilkins L; Oxford Foundation School, Health Education England - Thames Valley, Oxford, United Kingdom., Oliver M; South Thames Foundation School, Health Education England, London, United Kingdom., Kelly DF; From the Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom., Paulus SC; From the Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Calisto A; Department of Paediatric Neurosurgery, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Publikováno v:
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2023 Nov 01; Vol. 42 (11), pp. e417-e420. Date of Electronic Publication: 2023 Oct 11.
Autor:
Lees EA; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.; Fitzwilliam College, University of Cambridge, United Kingdom., Ives A; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Fowler D; Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom., Lakhoo K; Department of Paediatric Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Grant D; Department of Paediatric Radiology, John Radcliffe Hospital, Oxford, United Kingdom., Kelly D; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.; Oxford Vaccine Group and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Paulus S; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Segal S; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Gilchrist JJ; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Kew A; Hospital for Tropical Diseases, University College London, United Kingdom., Chiodini P; Hospital for Tropical Diseases, University College London, United Kingdom.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Kadambari S; From the Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.; Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, United Kingdom.
Publikováno v:
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2023 Sep 01; Vol. 42 (9), pp. e343-e345. Date of Electronic Publication: 2023 May 17.