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The conformation of the activation loop (T-loop) of protein kinases underlies enzymatic activity and influences the binding of small-molecule inhibitors. By using single-molecule fluorescence spectroscopy, we have determined that phosphorylated Auror
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::0d3d9356b023a239855ef7dbe6f9da60
http://hdl.handle.net/10044/1/49334
http://hdl.handle.net/10044/1/49334
Autor:
Gilburt JAH; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK., Girvan P; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK., Blagg J; Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , 15 Cotswold Road , Sutton , Surrey SM2 5NG , UK., Ying L; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK., Dodson CA; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK.; Department of Pharmacy and Pharmacology , University of Bath , Claverton Down , Bath BA2 7AY , UK . Email: c.a.dodson@bath.ac.uk.
Publikováno v:
Chemical science [Chem Sci] 2019 Mar 04; Vol. 10 (14), pp. 4069-4076. Date of Electronic Publication: 2019 Mar 04 (Print Publication: 2019).
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
Autor:
Gilburt JAH; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK., Sarkar H; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK., Sheldrake P; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK., Blagg J; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK., Ying L; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK., Dodson CA; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK.
Publikováno v:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Sep 11; Vol. 56 (38), pp. 11409-11414. Date of Electronic Publication: 2017 Aug 07.