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The conformation of the activation loop (T-loop) of protein kinases underlies enzymatic activity and influences the binding of small-molecule inhibitors. By using single-molecule fluorescence spectroscopy, we have determined that phosphorylated Auror
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::0d3d9356b023a239855ef7dbe6f9da60
http://hdl.handle.net/10044/1/49334
http://hdl.handle.net/10044/1/49334
Autor:
Gilburt JAH; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK., Girvan P; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK., Blagg J; Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , 15 Cotswold Road , Sutton , Surrey SM2 5NG , UK., Ying L; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK., Dodson CA; Molecular Medicine , National Heart & Lung Institute , Imperial College London , SAF Building , London SW7 2AZ , UK.; Department of Pharmacy and Pharmacology , University of Bath , Claverton Down , Bath BA2 7AY , UK . Email: c.a.dodson@bath.ac.uk.
Publikováno v:
Chemical science [Chem Sci] 2019 Mar 04; Vol. 10 (14), pp. 4069-4076. Date of Electronic Publication: 2019 Mar 04 (Print Publication: 2019).
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
Autor:
Gilburt JAH; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK., Sarkar H; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK., Sheldrake P; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK., Blagg J; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK., Ying L; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK., Dodson CA; National Heart & Lung Institute, SAF Building, Imperial College London, London, SW7 2AZ, UK.
Publikováno v:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Sep 11; Vol. 56 (38), pp. 11409-11414. Date of Electronic Publication: 2017 Aug 07.
Autor:
Segura-Peña, Dario, Hovet, Oda, Gogoi, Hemanga, Dawicki-McKenna, Jennine, Wøien, Stine Malene Hansen, Carrer, Manuel, Black, Ben E., Cascella, Michele, Sekulic, Nikolina
Publikováno v:
eLife; 6/7/2023, p1-30, 30p
Autor:
Lake, Eric W., Muretta, Joseph M., Thompson, Andrew R., Rasmussen, Damien M., Majumdar, Abir, Faber, Erik B., Ruff, Emily F., Thomas, David D., Levinson, Nicholas M.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/18/2018, Vol. 115 Issue 51, pE11894-E11903, 10p
Autor:
Abdul Azeez, Kamal R., Chatterjee, Sneha, Yu, Channing, Golub, Todd R., Sobott, Frank, Elkins, Jonathan M.
Publikováno v:
Nature Communications; 7/18/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p