Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Gilberto Fronza"'
Autor:
Chiara M. Biatta, Michele Paudice, Marco Greppi, Veronica Parrella, Alessia Parodi, Giuseppa De Luca, Gianna Maria Cerruti, Serafina Mammoliti, Cinzia Caroti, Paola Menichini, Gilberto Fronza, Silvia Pesce, Emanuela Marcenaro, Valerio G. Vellone
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Backgroundwe evaluated the concordance between immunohistochemical p53 staining and TP53 mutations in a series of HGSOC. Moreover, we searched for prognostic differences between p53 overexpression and null expression groups.Methodspatients affected b
Externí odkaz:
https://doaj.org/article/9f4e5b0ac58246178fb58e2c8630fa81
Autor:
Paola Monti, Silvia Ravera, Andrea Speciale, Irena Velkova, Giorgia Foggetti, Paolo Degan, Gilberto Fronza, Paola Menichini
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The TP53 tumor suppressor gene is one of the most studied gene in virtue of its ability to prevent cancer development by regulating apoptosis, cell cycle arrest, DNA repair, autophagy and senescence. Furthermore, the modulation of metabolism by P53 i
Externí odkaz:
https://doaj.org/article/7351ae7bb2af454c80afec635a00e923
Autor:
Fortunato Morabito, Giovanni Tripepi, Riccardo Moia, Anna Grazia Recchia, Paola Boggione, Francesca Romana Mauro, Sabrina Bossio, Graziella D’Arrigo, Enrica Antonia Martino, Ernesto Vigna, Francesca Storino, Gilberto Fronza, Francesco Di Raimondo, Davide Rossi, Adalgisa Condoluci, Monica Colombo, Franco Fais, Sonia Fabris, Robin Foa, Giovanna Cutrona, Massimo Gentile, Emili Montserrat, Gianluca Gaidano, Manlio Ferrarini, Antonino Neri
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The prognostic role of lymphocyte doubling time (LDT) in chronic lymphocytic leukemia (CLL) was recognized more than three decades ago when the neoplastic clone’s biology was almost unknown. LDT was defined as the time needed for the peripheral blo
Externí odkaz:
https://doaj.org/article/8d9bb02c8fd04c81846d3d2f1ab2d91e
Autor:
Paola Monti, Paola Menichini, Andrea Speciale, Giovanna Cutrona, Franco Fais, Elisa Taiana, Antonino Neri, Riccardo Bomben, Massimo Gentile, Valter Gattei, Manlio Ferrarini, Fortunato Morabito, Gilberto Fronza
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The human TP53 locus, located on the short arm of chromosome 17, encodes a tumour suppressor protein which functions as a tetrameric transcription factor capable of regulating the expression of a plethora of target genes involved in cell cycle arrest
Externí odkaz:
https://doaj.org/article/b359c943d7f44811852f95eee85af7b6
Autor:
Paola Monti, Vaclav Brazda, Natália Bohálová, Otília Porubiaková, Paola Menichini, Andrea Speciale, Renata Bocciardi, Alberto Inga, Gilberto Fronza
Publikováno v:
Genes, Vol 12, Iss 2, p 277 (2021)
P53, P63, and P73 proteins belong to the P53 family of transcription factors, sharing a common gene organization that, from the P1 and P2 promoters, produces two groups of mRNAs encoding proteins with different N-terminal regions; moreover, alternati
Externí odkaz:
https://doaj.org/article/f4fb1b4d1fd44c8fb67dca8c8da3abe3
Autor:
Barbara Marengo, Alessandra Pulliero, Maria Valeria Corrias, Riccardo Leardi, Emanuele Farinini, Gilberto Fronza, Paola Menichini, Paola Monti, Lorenzo Monteleone, Giulia Elda Valenti, Andrea Speciale, Patrizia Perri, Francesca Madia, Alberto Izzotti, Cinzia Domenicotti
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 2, p 107 (2021)
Neuroblastoma (NB) accounts for about 8–10% of pediatric cancers, and the main causes of death are the presence of metastases and the acquisition of chemoresistance. Metastatic NB is characterized by MYCN amplification that correlates with changes
Externí odkaz:
https://doaj.org/article/bfca05fcfa3e4f78abc270befb9f9390
Autor:
Paola Menichini, Paola Monti, Andrea Speciale, Giovanna Cutrona, Serena Matis, Franco Fais, Elisa Taiana, Antonino Neri, Riccardo Bomben, Massimo Gentile, Valter Gattei, Manlio Ferrarini, Fortunato Morabito, Gilberto Fronza
Publikováno v:
Cells, Vol 10, Iss 1, p 98 (2021)
Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis. TP53 gene is mutated in more
Externí odkaz:
https://doaj.org/article/67b53e7cbe394c809b68b9edf6e9e21c
Autor:
Domenica Ronchetti, Vanessa Favasuli, Paola Monti, Giovanna Cutrona, Sonia Fabris, Ilaria Silvestris, Luca Agnelli, Monica Colombo, Paola Menichini, Serena Matis, Massimo Gentile, Ramil Nurtdinov, Roderic Guigó, Luca Baldini, Gilberto Fronza, Manlio Ferrarini, Fortunato Morabito, Antonino Neri, Elisa Taiana
Publikováno v:
Non-Coding RNA, Vol 6, Iss 1, p 11 (2020)
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in chronic lymphocytic leukemia (CLL) are still open questions. Herein, we investigated the significance of the lncRNA NEAT1 in CLL. We examined NEAT1 expression in 310 n
Externí odkaz:
https://doaj.org/article/620a03aecdeb4749a5cc643c8845d561
Autor:
Paola Campomenosi, Paola Assereto, Massimo Bogliolo, Gilberto Fronza, Angelo Abbondandolo, Antonella Capasso, Patrizia F. Bellomo, Roberto Monaco, Anna Rapallo, Andrea Sciutto, Roberto Orecchia, Elio Geido, Walter Giaretti
Publikováno v:
Analytical Cellular Pathology, Vol 17, Iss 1, Pp 1-12 (1998)
The p53 tumour suppressor gene has an important role in the the maintenance of genome stability and its mutational inactivation may be at the origin of aneuploidy in cancer cells. The aim of this study was to determine whether p53 mutations were asso
Externí odkaz:
https://doaj.org/article/d245d921cb234739b76d4daa89b5b012
Autor:
Ivan Raimondi, Yari Ciribilli, Paola Monti, Alessandra Bisio, Loredano Pollegioni, Gilberto Fronza, Alberto Inga, Paola Campomenosi
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69152 (2013)
The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. Also PRODH2, which degrades 4-hydroxy-L-
Externí odkaz:
https://doaj.org/article/01ad8eb54d6948fc822cb29ec5e22895