Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Gilberto De Nucci"'
Autor:
Eric Xavier Dos Santos, José Britto-Júnior, João Victor Ribeiro, Gilberto Quirino Junior, Antonio Tiago Lima, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, André Schenka, Gilberto De Nucci
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
6-Nitrodopamine (6-ND) is the predominant catecholamine released from isolated vascular tissues in both mammals and reptiles, with its release being significantly reduced by the NO synthesis inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME). The
Externí odkaz:
https://doaj.org/article/707da287b1bc47218ee2c2fdd58bb853
Autor:
José Britto-Júnior, Rafael Furlaneto, Antonio Tiago Lima, Mariana Gonçalves de Oliveira, Beatrice Severino, Francesco Frecentese, Ferdinando Fiorino, Giuseppe Caliendo, Marcelo Nicolás Muscará, Gilberto De Nucci
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: The human umbilical artery (HUA), rat-isolated right atrium, and rat-isolated vas deferens present a basal release of 6-nitrodopamine (6-ND). The basal release of 6-ND from these tissues was significantly decreased (but not abolished) w
Externí odkaz:
https://doaj.org/article/2f38f458f02f4026a5a5f710af3f2c29
Autor:
Rosa Sparaco, Pierfrancesco Cinque, Antonia Scognamiglio, Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Paolo Luciano, Marcello Casertano, Anna Aiello, Gustavo Yuri Martins Viegas, Gilberto De Nucci, Francesco Frecentese
Publikováno v:
Molecules, Vol 29, Iss 7, p 1598 (2024)
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats. As part of our follow-up t
Externí odkaz:
https://doaj.org/article/1faca57576ae452e9550a466612b7446
Autor:
José Britto-Júnior, Lincoln Rangel Medeiros-Teixeira, Antonio Tiago Lima, Letícia Costa Dassow, Rodrigo Álvaro Brandão Lopes-Martins, Rafael Campos, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, Gilberto De Nucci
Publikováno v:
Life, Vol 13, Iss 10, p 2012 (2023)
Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine. Here, we determined whether 6-nitrodopamine is released from rat isolated ventricles (RI
Externí odkaz:
https://doaj.org/article/99fc96d10b8d4ce981b93dcc227ce856
Autor:
Nura A. Mohamed, Haissam Abou-Saleh, Yu Kameno, Isra Marei, Gilberto de Nucci, Blerina Ahmetaj-Shala, Fisnik Shala, Nicholas S. Kirkby, Lewis Jennings, Dana E. Al-Ansari, Robert P. Davies, Paul D. Lickiss, Jane A. Mitchell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Pulmonary arterial hypertension (PAH) is an incurable disease, although symptoms are treated with a range of dilator drugs. Despite their clinical benefits, these drugs are limited by systemic side-effects. It is, therefore, increasingly rec
Externí odkaz:
https://doaj.org/article/8e7b211a296b4ff6ae224dc791158fee
Autor:
Natalícia de Jesus Antunes, Fernanda de Lima Moreira, Karin Kipper, Lewis Couchman, Daniel Temponi Lebre, Atholl Johnston, Gilberto De Nucci
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 28 (2022)
This study predicted dapaconazole clinical drug–drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo extrapolation equation, IVIVE) and dynamic (PBPK model) approaches. The in vitro inhibition of
Externí odkaz:
https://doaj.org/article/0ff5ee82dc434723913dbb51699e8b49
Autor:
Rosa Sparaco, Antonia Scognamiglio, Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Paolo Luciano, Marcello Casertano, Anna Aiello, Gilberto De Nucci, Francesco Frecentese
Publikováno v:
Molecules, Vol 28, Iss 1, p 57 (2022)
We recently identified 6-nitrodopamine and other nitro-catecholamines (6-nitrodopa, 6-nitroadrenaline), indicating that the endothelium has the ability to nitrate the classical catecholamines (dopamine, noradrenaline, and adrenaline). In order to inv
Externí odkaz:
https://doaj.org/article/3ac93dbbe8a24c28ab6152444f9fa139
Autor:
José Britto-Júnior, Felipe Fernandes Jacintho, Rafael Campos, David Halen Araújo Pinheiro, Guilherme M. Figueiredo Murari, Valéria B. de Souza, André A. Schenka, Fabíola Z. Mónica, Ronilson Agnaldo Moreno, Edson Antunes, Gilberto De Nucci
Publikováno v:
Biology Open, Vol 10, Iss 1 (2021)
The contractions of Chelonoidis carbonaria aortic rings induced by electrical field stimulation (EFS) are not inhibited by blockade of the voltage-gated sodium channels by tetrodotoxin but almost abolished by the α1/α2-adrenoceptor antagonist phent
Externí odkaz:
https://doaj.org/article/41d2cbe92c7b4523bb5e41f59a75443a
Autor:
José Britto‐Júnior, David H. A. Pinheiro, Alberto F. O. Justo, Guilherme M. Figueiredo Murari, Rafael Campos, Fernanda V. Mariano, Valéria B. deSouza, André A. Schenka, Fabiola Z. Mónica, Edson Antunes, Gilberto De Nucci
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Electrical field stimulation (EFS) induces contractions of both snake aorta and human umbilical cord vessels (HUCV) which were dependent on the presence of the endothelium. This study aimed to establish the nature of the mediator(s) responsi
Externí odkaz:
https://doaj.org/article/e7d2a03701ea481190c6f717f4bd6037
Autor:
Beatrice Severino, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Giuseppe Caliendo, Vincenzo Santagada, Elisa Magli, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Natalícia J. Antunes, Julio Rojas-Moscoso, Noedi L. de Freitas, Gustavo D. Mendes, Gilberto De Nucci
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na+/Ca2+ exchanger (NC
Externí odkaz:
https://doaj.org/article/786b7753f733401cb60d56c62520bbfb