Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gilbert X. Gonzalez"'
Autor:
Wandi Zhu, Lai Wei, Chunhong Dong, Ye Wang, Joo Kim, Yao Ma, Gilbert X. Gonzalez, Bao-Zhong Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 421-437 (2022)
Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently prevent infectious diseases and are safe in animal models and humans. In this study, we fabricated a multivalent influenza mRNA lipid nanoparticle (LNP) vacc
Externí odkaz:
https://doaj.org/article/13e2101a7c6940d088ca27f0046f8e01
Autor:
Lei Deng, Teena Mohan, Timothy Z. Chang, Gilbert X. Gonzalez, Ye Wang, Young-Man Kwon, Sang-Moo Kang, Richard W. Compans, Julie A. Champion, Bao-Zhong Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Relatively well conserved domains of influenza A virus (IAV) proteins are potential candidates for the development of a universal IAV vaccine. Here, Deng et al. combine two such conserved antigens (M2e and HA stalk) in a double-layered protein nanopa
Externí odkaz:
https://doaj.org/article/1e1b7e376b26409f8f98647986ff3a30
Autor:
Yao Ma, Ye Wang, Chunhong Dong, Gilbert X. Gonzalez, Wandi Zhu, Joo Kim, Lai Wei, Sang‐Moo Kang, Bao‐Zhong Wang
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 18(25)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global pandemic. The virus is rapidly evolving, characterized by the emergence of several major variants. Stable prefusion spike protein (Pre) is the immunogen in current vac
Autor:
Yufeng Song, Wandi Zhu, Ye Wang, Lei Deng, Yao Ma, Chunhong Dong, Gilbert X. Gonzalez, Joo Kim, Lai Wei, Sang-Moo Kang, Bao-Zhong Wang
Publikováno v:
Biomaterials. 287
The influenza epidemics pose a significant threat to public health. Of them, type B influenza coincided with several severe flu outbreaks. The efficacy of the current seasonal flu vaccine is limited due to the antigenicity changes of circulating stra
Autor:
Chunhong Dong, Ye Wang, Wandi Zhu, Yao Ma, Joo Kim, Lai Wei, Gilbert X. Gonzalez, Bao-Zhong Wang
Publikováno v:
ACS applied materialsinterfaces. 14(5)
The intranasal (i.n.) route is an ideal vaccination approach for infectious respiratory diseases like influenza. Polycationic polyethylenimine (PEI) could form nanoscale complexes with negatively charged viral glycoproteins. Here we fabricated PEI-he
Autor:
Yufeng Song, Gilbert X. Gonzalez, Chunhong Dong, Lai Wei, Wandi Zhu, Ye Wang, Joo Kim, Bao-Zhong Wang, Yao Ma
Publikováno v:
Nanomedicine
Influenza viral infection causes acute upper respiratory diseases in humans, posing severe risks to global public health. However, current vaccines provide limited protection against mismatched circulating influenza A viruses. Here, the immune respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adca9d8af6c4378d75b97dbafda6df3
https://europepmc.org/articles/PMC8897236/
https://europepmc.org/articles/PMC8897236/
Autor:
Richard W. Compans, Shelly Wang, Sang-Moo Kang, Gilbert X. Gonzalez, Yufeng Song, Yao Ma, Chunhong Dong, Bao-Zhong Wang, Ye Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance A noninvasive intranasal (i.n.) influenza vaccine can induce mucosal immune responses in respiratory tracts, preventing infection at the portal of virus entry. However, the absence of appropriate mucosal adjuvants at present hinders the
Autor:
Yuan Luo, Winston P. Pewin, Mark R. Prausnitz, Bao-Zhong Wang, Chao Wang, Teena Mohan, Wandi Zhu, Gilbert X. Gonzalez
Publikováno v:
Journal of Controlled Release. 261:1-9
The biodegradable microneedle patch (MNP) is a novel technology for vaccine delivery that could improve the immunogenicity of vaccines. To broaden the protective efficiency of conventional influenza vaccines, a new 4M2e-tFliC fusion protein construct
Autor:
Latika Luthra, Gilbert X. Gonzalez, Bao-Zhong Wang, Lei Deng, Yao Ma, Jun Zou, Sang-Moo Kang, Ye Wang, Chunhong Dong
Publikováno v:
Advanced Healthcare Materials. 9:1901176
The development of a universal influenza vaccine is an ideal strategy to eliminate public health threats from influenza epidemics and pandemics. This ultimate goal is restricted by the low immunogenicity of conserved influenza epitopes. Layered prote