Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gilbert T. Kelly"'
Publikováno v:
The Journal of Organic Chemistry. 84:2991-2996
The azinomycins are a family of aziridine-containing antitumor antibiotics and represent a treasure trove of biosynthetic reactions. The formation of the azabicyclo[3.1.0]hexane ring and functionalization of this ring system remain the least understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f099c38cca69b80663287cc642c42886
https://doi.org/10.1021/acs.joc.8b03007
https://doi.org/10.1021/acs.joc.8b03007
Autor:
Dioscar Delgado, Vasudha Sharma, Vishruth Gowda, Shogo Mori, Keshav K. Nepal, Coran M. H. Watanabe, Dinesh Simkhada, Gilbert T. Kelly
Publikováno v:
Biochemistry. 56(6)
The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b50dc558ac6eaa5729864e70629cad
https://pubmed.ncbi.nlm.nih.gov/28135072
https://pubmed.ncbi.nlm.nih.gov/28135072
Publikováno v:
Organic Letters. 11:4006-4009
Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d082a4970b46af45dd107611781e2d46
https://doi.org/10.1021/ol9016639
https://doi.org/10.1021/ol9016639
Publikováno v:
Bioorganic Chemistry. 36:4-15
Azinomycin B is an environmental DNA crosslinking agent produced by the soil microorganism Streptomyces sahachiroi. While the agent displays potent cytotoxic activities against leukemic cell lines and animal mouse models, the lack of a consistent sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3319f05c8da40e432bf701c817eb50fe
https://doi.org/10.1016/j.bioorg.2007.08.002
https://doi.org/10.1016/j.bioorg.2007.08.002
Publikováno v:
Chemistry & Biology. 13(5):485-492
SummaryStudies on the mechanism of action of the antitumor agent azinomycin B in vitro suggest that the drug elicits its lethal effects by the formation of interstrand crosslinks within the major groove of DNA. Here, we demonstrate the biological eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353a6336f425d55f0d55626e2d9f6ec6
Publikováno v:
Organic Letters. 8:1065-1068
[reaction: see text] Azinomycins have potential therapeutic value as antitumor agents; however, their biosynthesis is poorly understood. Here, we provide the first demonstration of a protein cell-free system capable of supporting complete in vitro bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ef0488ce5aea495b9253f27337c917
https://doi.org/10.1021/ol052987l
https://doi.org/10.1021/ol052987l
Publikováno v:
Organic letters. 10(21)
Streptomyces sahachiroi whole cell feeding experiments, utilizing putative precursors labeled with stable isotopes, established that the epoxide unit of the DNA cross-linked agents, azinomycin A and B, proceeds via a valine-dependent pathway and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849e8eb31cc38608f73170321b253fc1
https://pubmed.ncbi.nlm.nih.gov/18841989
https://pubmed.ncbi.nlm.nih.gov/18841989
Publikováno v:
Organic Letters; Oct2008, Vol. 10 Issue 21, p4815-4818, 4p