Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gilbert J. Rahme"'
Autor:
Tyler W. Jenkins, Sondra L. Downey-Kopyscinski, Jennifer L. Fields, Gilbert J. Rahme, William C. Colley, Mark A. Israel, Andrey V. Maksimenko, Steven N. Fiering, Alexei F. Kisselev
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Proteasome inhibitors bortezomib and carfilzomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have demonstrated clinical efficacy for the treatment of acute lymphoblastic leukemia (ALL). The t(4;11)(q21;q23
Externí odkaz:
https://doaj.org/article/f287ffb014d44282a148d0dbf994ac53
Autor:
Ik Soo Kim, Jingyi Wu, Gilbert J. Rahme, Sofia Battaglia, Atray Dixit, Elizabeth Gaskell, Huidong Chen, Luca Pinello, Bradley E. Bernstein
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108222- (2020)
Summary: Early developmental specification can be modeled by differentiating embryonic stem cells (ESCs) to embryoid bodies (EBs), a heterogeneous mixture of three germ layers. Here, we combine single-cell transcriptomics and genetic recording to cha
Externí odkaz:
https://doaj.org/article/fece313ef83448d692e034dc7165f61e
Autor:
Mark A. Israel, Yasuyuki Hitoshi, Steven N. Fiering, Eric J. Bivona, Chao Cheng, Alison L. Young, Zhonghua Zhang, Gilbert J. Rahme
Legend for Supplementary Figures S1-S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f48147eb5980a70ef3aa209cf33cb5
https://doi.org/10.1158/0008-5472.22408394.v1
https://doi.org/10.1158/0008-5472.22408394.v1
Autor:
Mark A. Israel, Yasuyuki Hitoshi, Steven N. Fiering, Eric J. Bivona, Chao Cheng, Alison L. Young, Zhonghua Zhang, Gilbert J. Rahme
Pearson correlation scores for RTK genes in TCGA 2008 GBM dataset.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae250da4e5a497ea421de6c0697d54d9
https://doi.org/10.1158/0008-5472.22408361.v1
https://doi.org/10.1158/0008-5472.22408361.v1
Autor:
Mark A. Israel, Yasuyuki Hitoshi, Steven N. Fiering, Eric J. Bivona, Chao Cheng, Alison L. Young, Zhonghua Zhang, Gilbert J. Rahme
Diagram depicting mouse transgenic alleles in PDGF-driven GBM model (S1); Gene expression analysis of PDGF-driven murine glioma and alignment with human GBM (S2); USP1 expression in GBM (S3); PDGF-B drives the expression of USP1 in mouse NSCs (S4); S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2a7d2c3e4d13ce81357c839ca01b37
https://doi.org/10.1158/0008-5472.22408391
https://doi.org/10.1158/0008-5472.22408391
Autor:
Mark A. Israel, Yasuyuki Hitoshi, Steven N. Fiering, Eric J. Bivona, Chao Cheng, Alison L. Young, Zhonghua Zhang, Gilbert J. Rahme
Glioblastoma is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of glioblastoma has identified distinct molecular subtypes of glioblastoma. Gain-of-function alterations lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b01fa6183ae52c0a79815c05da50275
https://doi.org/10.1158/0008-5472.c.6507518.v1
https://doi.org/10.1158/0008-5472.c.6507518.v1
Autor:
Gilbert J. Rahme, Nauman M. Javed, Kaitlyn L. Puorro, Shouhui Xin, Volker Hovestadt, Sarah E. Johnstone, Bradley E. Bernstein
Publikováno v:
Cancer Research. 83:3479-3479
Epigenetic lesions that disrupt gene regulatory elements and expression are increasingly recognized as potential drivers of human cancers. However, we currently lack the in vitro and in vivo models required to functionally validate such lesions and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b14bd8dbe997da866581e6aa80617e7
https://doi.org/10.1158/1538-7445.am2023-3479
https://doi.org/10.1158/1538-7445.am2023-3479
Autor:
William C. Colley, Jennifer Fields, Tyler W. Jenkins, Steven Fiering, Alexei F. Kisselev, Andrey V. Maksimenko, Sondra L. Downey-Kopyscinski, Gilbert J. Rahme, Mark A. Israel
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Proteasome inhibitors bortezomib and carfilzomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have demonstrated clinical efficacy for the treatment of acute lymphoblastic leukemia (ALL). The t(4;11)(q21;q23) chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1776622a9cd96b3fe2214421e70bfd40
http://europepmc.org/articles/PMC8149845
http://europepmc.org/articles/PMC8149845
Autor:
Volker Hovestadt, Gilbert J. Rahme, Elizabeth Gaskell, Abhijeet Shinde, Kyung Lock Kim, Daniel R. Jones, Efrat Shema, Ekaterina N. Andreishcheva, Bradley E. Bernstein, Peter van Galen
Publikováno v:
Cell reports methods
SUMMARY Epigenetic modifications control the stability and translation of mRNA molecules. Here, we present a microscopy-based platform for quantifying modified RNA molecules and for relating the modification patterns to single-cell phenotypes. We dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a106b4a5695ea55cf9cde692ab5e5ed4
https://doi.org/10.1016/j.crmeth.2021.100061
https://doi.org/10.1016/j.crmeth.2021.100061
Publikováno v:
Neuro-Oncology. 20:332-342
Background Mouse models of glioblastoma (GBM), the most aggressive primary brain tumor, are critical for understanding GBM pathology and can contribute to the preclinical evaluation of therapeutic agents. Platelet-derived growth factor (PDGF) signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e332c4624afc9dd1739a0b3996170e
https://doi.org/10.1093/neuonc/nox129
https://doi.org/10.1093/neuonc/nox129