Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gilbert Gaudel"'
Autor:
Gilbert Gaudel, M. Koch, S. Andrianomenjanahary, François Tillequin, Brigitte Renoux, Claude Monneret, X. Dong, Martine Mondon, P. Petit, Jean Claude Florent, Sylvie Michel, Jean-Pierre Gesson, Jacquesy Jc
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1093-1096
Daunorubicin substituted at N-3′ with a benzyloxycarbonyl group (self-immolative spacer) linked to an α-D-galactosyl residue such as 7a and 7b have been prepared as prodrugs. Conversion of 7a and 7b to daunorubicin will be mediated by an immunocon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edeb2af950e2c3334a9273e8c80b0e6a
https://doi.org/10.1016/s0960-894x(00)80625-3
https://doi.org/10.1016/s0960-894x(00)80625-3
Publikováno v:
Tetrahedron. 48:4885-4892
The chiral pool synthesis of enantiomerically pure anthracyclinone 6 from leucoquinizarin 10 , and from 3- O -benzyl-1,2- O -isopropylidene-3-C-methyl-α- D -ribo-pentodialdo-1,4-furanose ( 9 ) readily obtained from diacetone glucose, is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f02d85938403c5ecd404dcb0b72b5c
https://doi.org/10.1016/s0040-4020(01)81581-7
https://doi.org/10.1016/s0040-4020(01)81581-7
Publikováno v:
The Journal of Antibiotics. 48:1185-1187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1122fa46128672cb5d19e674a2bd6118
https://doi.org/10.7164/antibiotics.48.1185
https://doi.org/10.7164/antibiotics.48.1185
Autor:
Sofia Mitaku, Jean-Claude Jacquesy, Jean-Pierre Gesson, Xia Dong, Manfred Gerken, Klaus Bosslet, François Tillequin, Claude Monneret, Brigitte Renoux, Joerg Czech, Jean-Claude Florent, Sylvie Michel, Rainer Straub, Michel Koch, Martine Mondon, Solo Andrianomenjanahary, Gilbert Gaudel
Publikováno v:
Journal of medicinal chemistry. 41(19)
A series of new prodrugs of daunorubicin and doxorubicin which are candidates for antibody-directed enzyme prodrug therapy (ADEPT) is reported. These compounds (25a,b,c and 32a,b,c) have been designed to generate cytotoxic drugs after activation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796178c7dfafdcc1d44a2c0281a1adc7
https://pubmed.ncbi.nlm.nih.gov/9733483
https://pubmed.ncbi.nlm.nih.gov/9733483
Publikováno v:
Journal of medicinal chemistry. 36(10)
The synthesis and biological activity of the new 4-demethoxyanthracyclines 15, 22, and 23 are reported. They were obtained from synthetic 9-deacetyl-9-(hydroxymethyl)-4-demethoxydaunomycinone (isopropylidene derivative 9) and from 4-azido- or 4-amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcf3a233db56d11910aed20c032036f
https://pubmed.ncbi.nlm.nih.gov/8496904
https://pubmed.ncbi.nlm.nih.gov/8496904
Publikováno v:
HETEROCYCLES. 34:121
The first resolution of a racemic hydroxydihydropyranocoumarin, (±)-lomatin (1) was achieved by means of glycosidation, followed by separation of the diastereoisomeric glycosides and subsequent acid hydrolysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7955cfdfe4eea919208b518e9c9ff24b
https://doi.org/10.3987/com-91-5901
https://doi.org/10.3987/com-91-5901