Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Gilbert G. Privé"'
Autor:
Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151414- (2024)
The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isof
Externí odkaz:
https://doaj.org/article/3a8df14dd4c348f6b90cd509a98b511e
Autor:
Eitan Kugler, Shreyas Madiwale, Darren Yong, Julie A. I. Thoms, Yehudit Birger, David B. Sykes, Johannes Schmoellerl, Aneta Drakul, Valdemar Priebe, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Heather Ogana, Elisabeth Liedke, Jean-Pierre Bourquin, Johannes Zuber, Michael Milyavsky, John Pimanda, Gilbert G. Privé, Shai Izraeli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors contributing to leukemogenesis are poorly understood. Drug targeting a transcription f
Externí odkaz:
https://doaj.org/article/d7035b0bdc8b4304be06aaa591c4d83a
Autor:
Saskia Heybrock, Kristiina Kanerva, Ying Meng, Chris Ing, Anna Liang, Zi-Jian Xiong, Xialian Weng, Young Ah Kim, Richard Collins, William Trimble, Régis Pomès, Gilbert G. Privé, Wim Annaert, Michael Schwake, Joerg Heeren, Renate Lüllmann-Rauch, Sergio Grinstein, Elina Ikonen, Paul Saftig, Dante Neculai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.
Externí odkaz:
https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd
Autor:
Andrew J. Norris, Julian P. Whitelegge, Arman Yaghoubian, Jean-Rene Alattia, Gilbert G. Privé, Tatsushi Toyokuni, Hubert Sun, Mai N. Brooks, Luigi Panza, Pamela Matto, Federica Compostella, Natascha Remmel, Ralf Klingenstein, Konrad Sandhoff, Claire Fluharty, Arvan Fluharty, Kym F. Faull
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2254-2264 (2005)
A mass spectrometric method is described for monitoring cerebrosides in the presence of excess concentrations of alkali metal salts. This method has been adapted for use in the assay of arylsulfatase A (ASA) and the cerebroside sulfate activator prot
Externí odkaz:
https://doaj.org/article/c600c04ba285462aa709523f19ce2832
Autor:
Ahmed Mamai, Anh M. Chau, Brian J. Wilson, Iain D. Watson, Babu B. Joseph, Pandiaraju R. Subramanian, Monzur M. Morshed, Justin A. Morin, Michael A. Prakesch, Tianbao Lu, Pete Connolly, Douglas A. Kuntz, Neil C. Pomroy, Gennady Poda, Kong Nguyen, Richard Marcellus, Graig Strathdee, Brigitte Theriault, Ratheesh Subramaniam, Mohammed Mohammed, Ayome Abibi, Manuel Chan, Jeffrey Winston, Taira Kiyota, Elijus Undzys, Ahmed Aman, Nigel Austin, Marc Du Jardin, Kathryn Packman, Ulrike Phillippar, Riccardo Attar, James Edwards, Jeff O’Meara, David E. Uehling, Rima Al-awar, Gilbert G. Privé, Methvin B. Isaac
Publikováno v:
ACS Medicinal Chemistry Letters. 14:199-210
Autor:
Leandro Cerchietti, Ari M. Melnick, Masayuki Hirano, Gilbert G. Privé, Balázs Győrffy, Todd Evans, Haelee Ahn, Ingrid Torregroza, Geoffrey Lundell-Smith, Shao Ning Yang, Jude M. Phillip, Benet Pera Gresely, Rossella Marullo, Tharu M. Fernando
Supplementary Figures 1-8 Supplementary Tables 1-2 Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01a311eedd22c4494abb498526c1cf5
https://doi.org/10.1158/2159-8290.22532999.v1
https://doi.org/10.1158/2159-8290.22532999.v1
Autor:
Robert Kridel, Christian Steidl, David W. Scott, Merrill Boyle, Lauren C. Chong, Elizabeth A. Chavez, Rodger E. Tiedemann, Housheng Hansen He, Gilbert G. Privé, Maria C. Xu, Anjali Silva, Jesse Joynt, Michael Y. He, Tracy Lackraj, Mehran Bakhtiari, Keren Isaev, Sharon Yoon, Kit I. Tong
Results from CRISPR/Cas9 knockout screen in SU-DHL-4 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4c08af6454c34ea2a2834ec2eb5ad3
https://doi.org/10.1158/1078-0432.22481609.v1
https://doi.org/10.1158/1078-0432.22481609.v1
Autor:
Robert Kridel, Christian Steidl, David W. Scott, Merrill Boyle, Lauren C. Chong, Elizabeth A. Chavez, Rodger E. Tiedemann, Housheng Hansen He, Gilbert G. Privé, Maria C. Xu, Anjali Silva, Jesse Joynt, Michael Y. He, Tracy Lackraj, Mehran Bakhtiari, Keren Isaev, Sharon Yoon, Kit I. Tong
Purpose:The efficacy of EZH2 inhibition has been modest in the initial clinical exploration of diffuse large B-cell lymphoma (DLBCL), yet EZH2 inhibitors are well tolerated. Herein, we aimed to uncover genetic and pharmacologic opportunities to enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea15c004b3550df88ad0d2b64db44c
https://doi.org/10.1158/1078-0432.c.6530741.v1
https://doi.org/10.1158/1078-0432.c.6530741.v1
Autor:
Robert Kridel, Christian Steidl, David W. Scott, Merrill Boyle, Lauren C. Chong, Elizabeth A. Chavez, Rodger E. Tiedemann, Housheng Hansen He, Gilbert G. Privé, Maria C. Xu, Anjali Silva, Jesse Joynt, Michael Y. He, Tracy Lackraj, Mehran Bakhtiari, Keren Isaev, Sharon Yoon, Kit I. Tong
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedf107ae003a03ebdc635ba308d6ab9
https://doi.org/10.1158/1078-0432.22481612.v1
https://doi.org/10.1158/1078-0432.22481612.v1
Autor:
Eitan Kugler, Shreyas Madiwale, Darren Yong, Yehudit Birger, Julie AI Thoms, David B Sykes, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Michael Milyavsky, John Pimanda, Gilbert G Privé, Shai Izraeli
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S215-S216