Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gilbert Clincke"'
Publikováno v:
Brain Research. 745:210-221
Veratridine blocks Na(+)-channel inactivation and causes a persistant Na(+)-influx. Exposure of hippocampal slices to 10 microM veratridine led to a failure of synaptic transmission, repetitive spreading depression (SD)-like depolarizations of increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff513f9f2d4d38181a6abf3ffe90d30
https://doi.org/10.1016/s0006-8993(96)01094-3
https://doi.org/10.1016/s0006-8993(96)01094-3
Autor:
Guy Nagels, R. Frank Kooy, Kristel De Boulle, Gilbert Clincke, Rudi D'Hooge, Ben A. Oostra, Edwin Reyniers, Patrick Willems, Peter Paul De Deyn, Katrien Storm, Cathy E. Bakker
Publikováno v:
American Journal of Medical Genetics. 64:241-245
Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87cbd37e08297c74550d8e69d8d96eb2
https://doi.org/10.1002/(sici)1096-8628(19960809)64:2<241::aid-ajmg1>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19960809)64:2<241::aid-ajmg1>3.0.co
Publikováno v:
Behavioural brain research
Rats subjected to a one-way active avoidance task consisting of 3 daily training sessions, showed obvious shape changes in dendritic spines of the hippocampal supragranular molecular layer. Performance, expressed as the number of avoidances per 10 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a828fadad2e5259691105a503319026f
https://doi.org/10.1016/s0166-4328(05)80211-6
https://doi.org/10.1016/s0166-4328(05)80211-6
Publikováno v:
Brain Research. 573:44-60
The present study was aimed at delineating the neocortical substrate of tactile/proprioceptive limb placing reactions in rats by means of behavioral tests that excluded the participation of facial stimuli in limb function. Using a photochemical techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8279ab9cda82aa812716a4a09579d5ff
https://doi.org/10.1016/0006-8993(92)90112-m
https://doi.org/10.1016/0006-8993(92)90112-m
Publikováno v:
Drug Development Research. 23:301-305
In an open follow-up study, 31 elderly patients with real memory problems of unknown origin were treated for at least 10 months with sabeluzole 10 mg b.i.d. Not only were the same improvements seen as in the preceding double-blind trial on the cued r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2d2002aab0891586af5e1091c44634
https://doi.org/10.1002/ddr.430230403
https://doi.org/10.1002/ddr.430230403
Publikováno v:
Nature reviews. Drug discovery. 7(12)
In August 2008, lacosamide (Vimpat; UCB), was granted market authorization by the European Commission as an adjunctive therapy for partial-onset seizures with or without secondary generalization in patients with epilepsy. It was approved by the FDA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd1772406d6a82516348f077f692766
https://pubmed.ncbi.nlm.nih.gov/19043448
https://pubmed.ncbi.nlm.nih.gov/19043448
Publikováno v:
Drug Development Research. 20:473-482
Sabeluzole was studied in patients complaining spontaneously about their memory. They were screened and only included if they fitted into the AAMI-criteria and if, additionally, they were poor performers on a Selective Reminding Procedure (SRP). Fift
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2514990ce2fcdfaf472f7145ada1c0e
https://doi.org/10.1002/ddr.430200407
https://doi.org/10.1002/ddr.430200407
Autor:
Gilbert Clincke, D. Scheller, Stephan Szathmary, Jos Van Reempts, Frank Tegtmeier, Jochen Kolb, Marc De Ryck
Publikováno v:
European journal of pharmacology. 338(3)
A microdialysis probe was positioned inside the peri-infarct zone of a photochemically induced neocortical infarct in rats. Extracellular glutamate rose within 20 min after the start of infarct induction and continued to increase during the 5 h obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9f01abef45567ce8a2f39674bf8fe3
https://pubmed.ncbi.nlm.nih.gov/9424018
https://pubmed.ncbi.nlm.nih.gov/9424018
Publikováno v:
Acta Neurochirurgica Supplements ISBN: 9783709174180
Lubeluzole is a neuroprotective compound that has been shown to stereoselectively rescue sensorimotor function and reduce infarct size in a photochemical stroke model in rats. Tissue swelling, which occurs in the peri-infarct zone, is accompanied by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bcf03ea0daffb3e47c713e4e3aeec2c
https://doi.org/10.1007/978-3-7091-6837-0_57
https://doi.org/10.1007/978-3-7091-6837-0_57
Autor:
Gilbert Clincke, Theo F. Meert
Publikováno v:
Annals of the New York Academy of Sciences. 654
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2dd6cf58ba4c55cad930765d0eb29a
https://pubmed.ncbi.nlm.nih.gov/1632609
https://pubmed.ncbi.nlm.nih.gov/1632609