Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gilbert A. Keller"'
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 12, Pp 1921-1935 (2000)
At least three different subcellular compartments, including peroxisomes, are involved in cholesterol synthesis. The peroxisomal targeting signals for phosphomevalonate kinase and isopentenyl diphosphate isomerase have been identified. In the current
Externí odkaz:
https://doaj.org/article/22254f3732a442ba98a59eae5c6b960b
Autor:
Barry J. Sugarman, Laurence Jadin, Mathieu Marella, H. Michael Shepard, Gilbert A. Keller, Gregory I. Frost
Publikováno v:
Glycobiology
Modification of hyaluronan (HA) accumulation has been shown to play a key role in regulating inflammatory processes linked to the progression of multiple sclerosis (MS). The aim of this study was to characterize the enzymatic activity involved in HA
Publikováno v:
International Journal of Dermatology. 53:777-785
Background Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drain
Autor:
Rudolph D. Paladini, Anirban Kundu, Gilbert A. Keller, Qiping Zhao, Bookbinder Louis H, H. Michael Shepard, Gregory I. Frost, Ge Wei
Publikováno v:
Journal of Biological Chemistry. 288:6629-6639
Conditionally active proteins regulated by a physiological parameter represent a potential new class of protein therapeutics. By systematically creating point mutations in the catalytic and linker domains of human MMP-1, we generated a protein librar
Autor:
J.E. Lim, M.L. Zepeda, H. M. Shepard, Bookbinder Louis H, Gregory I. Frost, John S. Patton, M.F. Haller, A. Hofer, Gilbert A. Keller, Thomas S. Edgington
Publikováno v:
Journal of Controlled Release. 114:230-241
Subcutaneously injected therapeutics must pass through the interstitial matrix of the skin in order to reach their intended targets. This complex, three-dimensional structure limits the type and quantity of drugs that can be administered by local inj
Autor:
Gilbert-A. Keller, Wenlu Li
Publikováno v:
International Immunopharmacology. 3:493-512
We have previously shown in an in vitro wounding system of cultured endothelial cells (EC) that vascular endothelial growth factor (VEGF(165)) treatment upregulated the level of factor VIII (FVIII) in the cells facing an experimental wound. The FVIII
Publikováno v:
European Journal of Biochemistry. 268:4850-4859
At least three different subcellular compartments, including peroxisomes, are involved in cholesterol biosynthesis. Because proper CNS development depends on de novo cholesterol biosynthesis, peroxisomes must play a critical functional role in this p
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 12, Pp 1921-1935 (2000)
At least three different subcellular compartments, including peroxisomes, are involved in cholesterol synthesis. The peroxisomal targeting signals for phosphomevalonate kinase and isopentenyl diphosphate isomerase have been identified. In the current
Autor:
Georg H. Lüers, William B. Snyder, Thibaut José Wenzel, Klaas Nico Faber, Antonius Koller, Suresh Subramani, Linda Rangell, Gilbert A. Keller
Publikováno v:
Molecular Biology of the Cell. 10:1745-1761
We report the cloning and characterization of Pichia pastoris PEX19 by complementation of a peroxisome-deficient mutant strain. Import of peroxisomal targeting signal 1- and 2-containing peroxisomal matrix proteins is defective inpex19 mutants. PEX19
Autor:
Barbara D. Wright, Hans-Peter Gerber, Michel Aguet, Joe Kowalski, Kenneth J. Hillan, Linda Rangell, Freddy Radtke, Anne M. Ryan, Napoleone Ferrara, Gilbert-Andre Keller
Publikováno v:
Development. 126:1149-1159
We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP-mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF ac