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Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms

Autor: Ni, Tao, Gilbert, Robert J. C.

Publikováno v: Philosophical Transactions: Biological Sciences, 2017 Aug 01. 372(1726), 1-10.

Externí odkaz: https://www.jstor.org/stable/44679044

Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation

Autor: Yu, Xiulian, Ni, Tao, Munson, George, Zhang, Peijun, Gilbert, Robert J C

Perforin-2 (PFN2, MPEG1) is a key pore-forming protein in mammalian innate immunity restricting intracellular bacteria proliferation. It forms a membrane-bound pre-pore complex that converts to a pore-forming structure upon acidification; but its mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05e0e0d2fb9ca3382e017e94e57cc8a
https://ora.ox.ac.uk/objects/uuid:91034da8-3f47-4967-8ee1-f60de629f68e

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Editorial: Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis

Autor: Munson, George P., Gilbert, Robert J. C., Pradel, Gabriele

Publikováno v: Frontiers in immunology 13, 932502 (2022). doi:10.3389/fimmu.2022.932502 special issue: "Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis"

Frontiers in immunology 13, 932502 (2022). doi:10.3389/fimmu.2022.932502 special issue: "Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis"
Published by Frontiers Media, Lausanne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d62c95b2ab5d3d02c6a495e88d70b4
https://pubmed.ncbi.nlm.nih.gov/35757767