Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gilad Yaakov"'
Autor:
Marko Dunjić, Felix Jonas, Gilad Yaakov, Roye More, Yoav Mayshar, Yoach Rais, Ayelet-Hashahar Orenbuch, Saifeng Cheng, Naama Barkai, Yonatan Stelzer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Eviction of histones from nucleosomes and their exchange with newly synthesized or alternative variants is a central epigenetic determinant. Here, we define the genome-wide occupancy and exchange pattern of canonical and non-canonical histon
Externí odkaz:
https://doaj.org/article/a3c432554ed24441bcde9d8cfc86b425
Autor:
Maximilian Mosbacher, Sung Sik Lee, Gilad Yaakov, Mariona Nadal-Ribelles, Eulàlia de Nadal, Frank van Drogen, Francesc Posas, Matthias Peter, Manfred Claassen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ultrasensitivity in th
Externí odkaz:
https://doaj.org/article/0960943550834387b65d093a11cd7dac
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3229-3242 (2020)
Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology. Here, we analyze the consequences of engi
Externí odkaz:
https://doaj.org/article/275a0954350e4176a663abe0f85afd4a
Publikováno v:
eLife, Vol 6 (2017)
Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins. Theory show
Externí odkaz:
https://doaj.org/article/f980279d9d1940d1926119d5a826bfa6
Publikováno v:
Genome Research
DNA replication perturbs chromatin by triggering the eviction, replacement, and incorporation of nucleosomes. How this dynamic is orchestrated in time and space is poorly understood. Here, we apply a genetically encoded sensor for histone exchange to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c760f2e6ad08b7dafb4690ba60997b
https://doi.org/10.1101/gr.276674.122
https://doi.org/10.1101/gr.276674.122
Autor:
Marko Dunjić, Felix Jonas, Gilad Yaakov, Roye More, Yoav Mayshar, Yoach Rais, Naama Barkai, Yonatan Stelzer
Eviction of histones from nucleosomes and their exchange with newly synthesized or alternative variants is a central epigenetic determinant. Here, we define the genome-wide incorporation and exchange pattern of canonical and non-canonical histone var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac2fb06fcc8f9d203830df0b8ba1f55a
https://doi.org/10.1101/2022.11.16.516734
https://doi.org/10.1101/2022.11.16.516734
Publikováno v:
Nature biotechnology. 39(11)
Histone exchange between histones carrying position-specific marks and histones bearing general marks is important for gene regulation, but understanding of histone exchange remains incomplete. To overcome the poor time resolution of conventional pul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b613d4a87232ad0aa8a6c654045df01
https://pubmed.ncbi.nlm.nih.gov/34584249
https://pubmed.ncbi.nlm.nih.gov/34584249
Publikováno v:
Genome Res
The wrapping of DNA around histone octamers challenges processes that use DNA as their template. In vitro, DNA replication through chromatin depends on histone modifiers, raising the possibility that cells modify histones to optimize fork progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0926fdf59aedba7baa6616ff92a2c8bd
https://pubmed.ncbi.nlm.nih.gov/33563717
https://pubmed.ncbi.nlm.nih.gov/33563717
Autor:
Naama Barkai, Gilad Yaakov
Publikováno v:
Current Opinion in Systems Biology. 8:125-130
Robustness and evolvability are defining properties of biological systems. Robustness promotes reproducibility of central biological functions, primarily by maintaining low mutation frequency and small mutational effects. By contrast, evolvability is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d3eb404a2a0194276749af6b6b6c54f
https://doi.org/10.1016/j.coisb.2018.02.008
https://doi.org/10.1016/j.coisb.2018.02.008
Publikováno v:
Nature Biotechnology. 39:1467-1467
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be077bee4a1f3457665d8752c13cc99a
https://doi.org/10.1038/s41587-021-01103-2
https://doi.org/10.1038/s41587-021-01103-2