Multiple Regulatory Layers of SREBP1/2 by SIRT6

Autor: Sivan Elhanati, Yariv Kanfi, Alexander Varvak, Asael Roichman, Ilana Carmel-Gross, Shaul Barth, Gilad Gibor, Haim Y. Cohen

Publikováno v: Cell Reports, Vol 4, Iss 5, Pp 905-912 (2013)

The NAD+-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and lifespan. Mice overexpressing SIRT6 (MOSES) have lower low-density lipoprotein cholesterol levels and are protected against the physiological damage of obesity. Here

Externí odkaz: https://doaj.org/article/40ec652d95a4433f8056d09c69c5ae2b

An Inactivation Gate in the Selectivity Filter of KCNQ1 Potassium Channels

Autor: Guiscard Seebohm, Yoav Paas, Hella Schottelndreier, Daniel Yakubovich, Gilad Gibor, Asher Peretz, Avia Rosenhouse-Dantsker, Diomedes E. Logothetis, Bernard Attali, Nathan Dascal

Publikováno v: Biophysical Journal. 93(12):4159-4172

Inactivation is an inherent property of most voltage-gated K(+) channels. While fast N-type inactivation has been analyzed in biophysical and structural details, the mechanisms underlying slow inactivation are yet poorly understood. Here, we characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81629307d686411ffb08988daa60d3fd

Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Properties

Autor: Doron Shabat, Bernard Attali, Gilad Gibor, Asher Peretz, Yael Uziyel, Rachel Nachman, Nurit Degani

Publikováno v: Molecular Pharmacology. 67:1053-1066

The voltage-dependent M-type potassium current (M-current) plays a major role in controlling brain excitability by stabilizing the membrane potential and acting as a brake for neuronal firing. The KCNQ2/Q3 heteromeric channel complex was identified a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fce6a06123d0e089232271d9ce80f7e
https://doi.org/10.1124/mol.104.007112

Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade

Autor: Gilad Gibor, Alexander Plotnikov, Rony Seger, Yoav D. Shaul

Extracellular signal-regulated kinases (ERKs) are key signaling molecules that regulate a large number of cellular processes, including mitosis. We showed previously that ERK1c, an alternatively spliced form of ERK1, facilitates mitotic Golgi fragmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8d165098f3e52d78ef919599fad237
https://europepmc.org/articles/PMC2720265/

Pore conformations and gating mechanism of a Cys-loop receptor

Autor: Yoav Paas, Gilad Gibor, Bernard Attali, Lia Prado de Carvalho, Nathalie Savatier-Duclert, Régis Grailhe, Virginie Dufresne, Morten Sunesen, Jean-Pierre Changeux

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (44), pp.15877-82. ⟨10.1073/pnas.0507599102⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2005, 102 (44), pp.15877-82. ⟨10.1073/pnas.0507599102⟩

Neurons regulate the propagation of chemoelectric signals throughout the nervous system by opening and closing ion channels, a process known as gating. Here, histidine-based metal-binding sites were engineered along the intrinsic pore of a chimeric C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7978b5e7d155fe91732358d130904d0a
https://pubmed.ncbi.nlm.nih.gov/16247006