Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Gila, Arad"'
Autor:
Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-16 (2023)
Abstract Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulato
Externí odkaz:
https://doaj.org/article/72abed205b8b4743a7793760acc8aa32
Publikováno v:
Toxins, Vol 5, Iss 9, Pp 1531-1542 (2013)
Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune respo
Externí odkaz:
https://doaj.org/article/54d5b2359ca14b6fad505df992d8f20a
Autor:
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer
Publikováno v:
PLoS Biology, Vol 13, Iss 8, p e1002237 (2015)
Externí odkaz:
https://doaj.org/article/a3404a90428d4020b2cf09124f5e6d82
Autor:
Uzorchukwu Michael Ogu, Nur Hidayah Jamar, Douglas Law, Ziv Rotfogel, Hind Chakchak, D. T. Sakhare, Aziz Chaouch, Mahanem Mat Noor, Deepti Joshi, Ahmad Azfaralariff, Shazrul Fazry, Izabel Luzia Miranda, Sujit Kumar Shah, Man Singh, Hamid Zineddine, B. D. Kalyankar, Sameer A. Karpe, Amarachi Maduka, Marisa Alves Nogueira Diaz, Siti Aisyah Sanusi, Charity Ebere Anarado, Benjamin Chimezie Izuagbachukwu, Chinyelu Ijeamaka Egwuatu, Chigozie John Onyinye Anarado, Herryawan Ryadi Eziwar Dyari, Geeta Verma, Nik Marzuki Sidik, Gaspar Diaz-Muñoz, S. Sophie Beulah, Iris Nasie, Sujeet Kumar Chatterjee, Babul Airianah Othman, Valentine Ifenna Onwukeme, Yi Chieh Lim, Ajaya Bhattarai, Muhammad Akram Mohd Noordin, Madhup Chandra, Revital Levy, Suélen K. Sartori, Azwan Mat Lazim, K. Muthukumaran, Gila Arad, K.M. Sachin, Raymond Kaempfer, Yew Hoong Cheah, Dalia Hillman, S. P. Vartale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d31d2ad07a67f056f26a3a252bc6c2d
https://doi.org/10.9734/bpi/cpcs/v1
https://doi.org/10.9734/bpi/cpcs/v1
Autor:
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer
Publikováno v:
PLoS Biology, Vol 9, Iss 9, p e1001149 (2011)
Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an
Externí odkaz:
https://doaj.org/article/2c5298f26ef74f0fa8ebd46414d22eec
Autor:
Raymond, Kaempfer, Andrey, Popugailo, Revital, Levy, Gila, Arad, Dalia, Hillman, Ziv, Rotfogel
Publikováno v:
Receptorsclinical investigation. 4(1)
Formation of the costimulatory axis between the B7-2 and CD28 coreceptors is critical for T-cell activation. Superantigens, Gram-positive bacterial virulence factors, cause toxic shock and sepsis by hyperinducing inflammatory cytokines. We report a n
Publikováno v:
Toxins
Toxins, Vol 5, Iss 9, Pp 1531-1542 (2013)
Toxins, Vol 5, Iss 9, Pp 1531-1542 (2013)
Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune respo
Autor:
Emmanuelle Supper, Ziv Rotfogel, Dalia Hillman, Revital Levy, Farhat Osman, Gila Arad, Andrey Popugailo, Raymond Kaempfer
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Full T-cell activation requires interaction between the costimulatory receptors B7-2 and CD28. By binding CD28, bacterial superantigens elicit harmful inflammatory cytokine overexpression through an unknown mechanism. We show that, by engaging not on
Publikováno v:
Immunology Letters. 82:75-78
Superantigens, exemplified by staphylococcal enterotoxin B (SEB), are the strongest known inducers of a cellular immune response; they elicit the production of excessive amounts of Th1 cytokines, IL-2, IFN-gamma and TNF, leading to toxic shock. We sh
Bacterial superantigens are among the most lethal of toxins. These stable proteins bind directly to most major histocompatibility (MHC) class II molecules and stimulate virtually all T cells bearing particular domains in the variable portion of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3808c703651583fa7383325a9543b3b
https://doi.org/10.1128/9781555815844.ch14
https://doi.org/10.1128/9781555815844.ch14