Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gil Speyer"'
Publikováno v:
ACS Omega, Vol 5, Iss 33, Pp 20874-20881 (2020)
Externí odkaz:
https://doaj.org/article/e896b67ece524c7888111165ba8801f7
Publikováno v:
BMC Bioinformatics, Vol 18, Iss S7, Pp 69-78 (2017)
Abstract Background Genomic analysis of drug response can provide unique insights into therapies that can be used to match the “right drug to the right patient.” However, the process of discovering such therapeutic insights using genomic data is
Externí odkaz:
https://doaj.org/article/f7ea340a18814c79ab2405085d08e169
Publikováno v:
Practice and Experience in Advanced Research Computing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab07d6b033ee1ffc578a6f941dc0b94
https://doi.org/10.1145/3491418.3535187
https://doi.org/10.1145/3491418.3535187
Autor:
John Sembrat, Seyed Mehdi Nouraie, Bryan J. McVerry, Jeremy A. Mazurek, Neil J. Kelly, Sathish Badu Vasamsetti, Dennis M. McNamara, Yassmin Al Aaraj, Partha Dutta, Anjali Vaidya, Frank C. Sciurba, Yi-Yin Tai, Yuchi Han, Zeyu Xiong, Mauricio Rojas, Makenna E. Romanelli, Janet S. Lee, Annie M. Watson, Yingze Zhang, Marc A. Simon, Charles F. McTiernan, Adam Handen, Kerri Akaya Smith, Wei Sun, Jingsi Zhao, Stephen Y. Chan, Gil Speyer, Ying Tang, Seungchan Kim
Publikováno v:
JACC: Basic to Translational Science. 5:1073-1092
Utilizing publicly available ribonucleic acid sequencing data, we identified SCUBE1 as a BMPR2-related gene differentially expressed between induced pluripotent stem cell-endothelial cells derived from pulmonary arterial hypertension (PAH) patients c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a0893ceb3696bb4fdca005df2d253e6
https://doi.org/10.1016/j.jacbts.2020.08.010
https://doi.org/10.1016/j.jacbts.2020.08.010
Autor:
Maryam Sharifi-Sanjani, Andres Pulgarin, Ying Tang, Sébastien Bonnet, John Sembrat, Patricia Forsythe, Annie M. Watson, Imad Al Ghouleh, Miranda K. Culley, Bridget K. Wagner, Thomas Bertero, Vinny Negi, Seungchan Kim, Qiujun Yu, Jimin Yang, Xianglin Yin, Yassmin Al Aaraj, Anastasia Gorelova, Taijyu Satoh, Stéphanie Torrino, Arun Rajaratnam, Jingsi Zhao, Stephen Y. Chan, Stuart L. Schreiber, Gil Speyer, Mauricio Rojas, Sara O. Vargas, Mingji Dai, Steeve Provencher, Adam Handen, Yi Yin Tai
Publikováno v:
Science Advances
Description
A network dependency platform was generated to define a landscape of cancer drug mechanisms in pulmonary hypertension.
Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH
A network dependency platform was generated to define a landscape of cancer drug mechanisms in pulmonary hypertension.
Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1721684f9c583fd65565e41c603b50d
https://pubmed.ncbi.nlm.nih.gov/34669463
https://pubmed.ncbi.nlm.nih.gov/34669463
Autor:
Leonard E Estephan, Ying Tang, Neha Hafeez, Seungchan Kim, Thomas Bertero, Stephen Y. Chan, Gil Speyer, Lloyd D. Harvey, Adam Handen, Chen-Shan Chen Woodcock
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2021, 320 (5), pp.L726-L738. ⟨10.1152/ajplung.00407.2020⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2021, 320 (5), pp.L726-L738. ⟨10.1152/ajplung.00407.2020⟩
International audience; Pulmonary arterial hypertension (PAH) refers to a set of heterogeneous vascular diseases defined by elevation of pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), leading to right ventricular (RV) remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335edaad629d93fc4294f646055ba5cf
https://pubmed.ncbi.nlm.nih.gov/33565360
https://pubmed.ncbi.nlm.nih.gov/33565360
Autor:
Gil Speyer, Neha Hafeez, Leonard E Estephan, Adam Handen, Thomas Bertero, Chen-shan J Woodcock, Stephen Y. Chan, Ying Tang, Seungchan Kim
Publikováno v:
Circulation. 142
Introduction: Early increases in pulmonary artery stiffness drive pathogenic alterations of pulmonary arterial endothelial cells (PAECs), leading to vascular remodeling, a prominent feature of pulmonary hypertension (PH). However, the molecular mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d0744b1df936a09756cec2d42d7686
https://doi.org/10.1161/circ.142.suppl_3.14698
https://doi.org/10.1161/circ.142.suppl_3.14698
Autor:
John Sembrat, Marc A. Simon, Charles F. McTiernan, Partha Dutta, Wei Sun, Yuchi Han, Gil Speyer, Mehdi Nouraie, Mauricio Rojas, Adam Handen, Yingze Zhang, Frank C. Sciurba, Bryan J. McVerry, Ying Tang, Zeyu Xiong, Makenna E. Romanelli, Neil J. Kelly, Annie M. Watson, Yassmin Al Aaraj, Sathish Babu Vasamsetti, A. Smith, Seungchan Kim, Janet S. Lee, Dennis M. McNamara, Jeremy A. Mazurek, Yi-Yin Tai, Anjali Vaidya, Jingsi Zhao, Stephen Y. Chan
Publikováno v:
Circulation. 142
Introduction: Pulmonary arterial hypertension (PAH) is a morbid vascular disease where mutations of bone morphogenetic protein receptor 2 (BMPR2) control pulmonary endothelial pathophenotypes. Transcriptomic screening from endothelial cells (ECs) der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b476f84e3f2cb3337aa066ca431c606d
https://doi.org/10.1161/circ.142.suppl_3.15826
https://doi.org/10.1161/circ.142.suppl_3.15826
Publikováno v:
PEARC
An R library application employing distinct resampling and multithreaded overlap routines demanded memory beyond the limits of a desktop workstation. Initial efforts revealed that the necessary memory allocations for the dataset output from the resam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e4cef9d8bea8fe4fdf80644fc447ab
https://doi.org/10.1145/3311790.3399624
https://doi.org/10.1145/3311790.3399624