Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gil Diamant"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
A subset of inflammatory-response NF-κB target genes is activated immediately after proinflammatory stimulation. Here, the authors show that in rapidly induced genes, depletion of the elongation factor Spt5 reduces transcription initiation and TFIID
Externí odkaz:
https://doaj.org/article/c9127e56ecfe458ea2abfce9b92e4384
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 722-731 (2012)
NF-κB is central for immune response and cell survival, and its deregulation is linked to chronic inflammation and cancer through poorly defined mechanisms. IκBα and A20 are NF-κB target genes and negative feedback regulators. Upon their activati
Externí odkaz:
https://doaj.org/article/b8c130f9389b4f7dace87ccd253ca933
Autor:
Tamar Shiloach, Marina Roitman, Lital Gasri Plotnitsky, Hadar Simchony Goldman, Ilan Volovitz, Oz Haim, Zvi Ram, Anat Globerson-Levin, Niv Pencovich, Zelig Eshhar, Rachel Grossman, Gil Diamant
Publikováno v:
The Journal of Immunology. 207:709-719
Tumor-treating fields (TTFields) are a localized, antitumoral therapy using alternating electric fields, which impair cell proliferation. Combining TTFields with tumor immunotherapy constitutes a rational approach; however, it is currently unknown wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a296741dd98033fae76d10674f106c5
https://doi.org/10.4049/jimmunol.2100100
https://doi.org/10.4049/jimmunol.2100100
Publikováno v:
Molecular and Cellular Biology. 36:1342-1353
The proinflammatory cytokine tumor necrosis factor alpha (TNF-α) modulates the expression of many genes, primarily through activation of NF-κB. Here, we examined the global effects of the elongation factor Spt5 on nascent and mature mRNAs of TNF-α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73854d48f2c515d43d33fc210ca3cabc
https://doi.org/10.1128/mcb.01117-15
https://doi.org/10.1128/mcb.01117-15
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
A subset of inflammatory-response NF-κB target genes is activated immediately following pro-inflammatory signal. Here we followed the kinetics of primary transcript accumulation after NF-κB activation when the elongation factor Spt5 is knocked down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9133eaf392ab6bdb59c4a647c1db10
https://doaj.org/article/c9127e56ecfe458ea2abfce9b92e4384
https://doaj.org/article/c9127e56ecfe458ea2abfce9b92e4384
Autor:
Gil Diamant, Hadar Simchony, Tamar Shiloach, Anat Globerson-levin, Lital Gasri Plotnitsky, Zelig Eshhar, Niv Pencovich, Rachel Grossman, Zvi Ram, Ilan Volovitz
Publikováno v:
Cancer Research. 79:3954-3954
Background: Combining Tumor Treating electrical Fields (TTFields) with immunotherapy is a rational approach due to their different mechanisms of action (MOA) and to TTFields’ ability to induce immunogenic cell death (ICD). Conversely, TTFields may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0697709c7cdc0a86f2dcbdcf60dda985
https://doi.org/10.1158/1538-7445.am2019-3954
https://doi.org/10.1158/1538-7445.am2019-3954
Autor:
Rivka Dikstein, Gil Diamant
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1829:937-945
The NF-κB family of transcription factors governs the cellular reaction to a variety of extracellular signals. Following stimulation, NF-κB activates genes involved in inflammation, cell survival, cell cycle, immune cell homeostasis and more. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7fda964cb11293be4af5ef7602b14e
https://doi.org/10.1016/j.bbagrm.2013.04.007
https://doi.org/10.1016/j.bbagrm.2013.04.007
Autor:
Ilan Volovitz, Merav Lustgarten, Marina Roitman, Zvi Ram, Roni Hagai, Gil Diamant, Barak Bensimhon, Nati Shapira, Rachel Grossman
Publikováno v:
Cancer Research. 78:2272-2272
Immune checkpoint molecules (ICMs) make up the immune suppressive network (ISN) that blocks spontaneous or therapy-induced anti-tumoral immune responses. A decade of research into checkpoint inhibitors (CPIs) has identified only few predictive biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8003b662f3cc8dd47bfd793fdcecc7a
https://doi.org/10.1158/1538-7445.am2018-2272
https://doi.org/10.1158/1538-7445.am2018-2272
Autor:
Anat Globerson-Levin, Zvi Ram, Zelig Eshhar, Ilan Volovitz, Hadar Simchony, Tamar Shiloach, Rachel Grossman, Gil Diamant
Publikováno v:
Cancer Research. 78:621-621
Background: Tumor Treating Fields (TTFields) are low-intensity electric fields that target proliferating cells by hindering mitotic spindle formation and charged organelle translocation. TTFields are FDA-approved for treatment of newly diagnosed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8326c16d426fbbe862ea0c1c099dac2
https://doi.org/10.1158/1538-7445.am2018-621
https://doi.org/10.1158/1538-7445.am2018-621
Autor:
Ilan Volovitz, Netanel Shapira, Idan Ben-Horin, Gil Diamant, T. Alter-Regev, Zvi Ram, A. Shenkar
Publikováno v:
Annals of Oncology. 28:xi25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37ffafa8d4c8c1c4c7f486212d3b9ca4
https://doi.org/10.1093/annonc/mdx711.068
https://doi.org/10.1093/annonc/mdx711.068