Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gil D. Hoftman"'
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/6a63c6368d064ab98d031f1ed76c282e
Autor:
Carolyn M. Amir, Simon Kapler, Gil D. Hoftman, Leila Kushan, Jamie Zinberg, Kristin S. Cadenhead, Leda Kennedy, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Diana O. Perkins, William Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon, Jean Addington, Carrie E. Bearden
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundElevated rates of alcohol, tobacco, and cannabis use are observed in both patients with psychotic disorders and individuals at clinical high risk for psychosis (CHR-P), and strong genetic associations exist between substance use disorders a
Externí odkaz:
https://doaj.org/article/8a9a5d57faa949ce9a94dd9e1750b6d4
Autor:
Amy Lin, Jennifer K. Forsyth, Gil D. Hoftman, Leila Kushan-Wells, Maria Jalbrzikowski, Deepika Dokuru, Giovanni Coppola, Ania Fiksinski, Janneke Zinkstok, Jacob Vorstman, Daniel Nachun, Carrie E. Bearden
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100386- (2021)
22q11.2 reciprocal copy number variants (CNVs) offer a powerful quasi-experimental “reverse-genetics” paradigm to elucidate how gene dosage (i.e., deletions and duplications) disrupts the transcriptome to cause further downstream effects. Clinica
Externí odkaz:
https://doaj.org/article/7bbf0d5c64de4d89987d58b825e1a27b
Autor:
Kathleen P. O’Hora, Leila Kushan-Wells, Gil D. Hoftman, Maria Jalbrzikowski, Raquel C. Gur, Ruben Gur, Carrie E. Bearden
Publikováno v:
medRxiv
Rare genetic variants that confer large effects on neurodevelopment and behavioral phenotypes can reveal novel gene-brain-behavior relationships relevant to autism. Copy number variation at the 22q11.2 locus offer one compelling example, as both the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687114d0383a50ed57b7c64698278717
https://europepmc.org/articles/PMC10246073/
https://europepmc.org/articles/PMC10246073/
Autor:
Jennifer K Forsyth, Jacob A. S. Vorstman, Deepika Dokuru, Gil D Hoftman, Giovanni Coppola, Carrie E. Bearden, Ania Fiksinski, Daniel Nachun, Janneke Zinkstok, Leila Kushan-Wells, Maria Jalbrzikowski, Amy Lin
Publikováno v:
Brain, Behavior, & Immunity-Health
Brain, Behavior, & Immunity-Health, Vol 18, Iss, Pp 100386-(2021)
Brain, Behavior, & Immunity-Health, 18. Elsevier Inc.
Brain, Behavior, & Immunity-Health, Vol 18, Iss, Pp 100386-(2021)
Brain, Behavior, & Immunity-Health, 18. Elsevier Inc.
22q11.2 reciprocal copy number variants (CNVs) offer a powerful quasi-experimental "reverse-genetics" paradigm to elucidate how gene dosage (i.e., deletions and duplications) disrupts the transcriptome to cause further downstream effects. Clinical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7728a57aba8ff0cadbcb56927b2656
https://escholarship.org/uc/item/2jm858qs
https://escholarship.org/uc/item/2jm858qs
Autor:
Gil D. Hoftman, Aaron Alexander-Bloch, Armin Raznahan, David C. Glahn, Theodore D. Satterthwaite, Josephine Mollon, Samuel R. Matthias, Emma Knowles, Simon N. Vandekar, Amanda L. Rodrigue, Raquel E. Gur, Danielle S. Bassett, Russell T. Shinohara, Siyuan Liu, John Blangero, Harald H. H. Görring, Laura Almasy, Jakob Seidlitz, Joanne E. Curran, Peter T. Fox, Godfrey D. Pearlson, Zhixin Lu
Publikováno v:
Proceedings of the National Academy of Sciences. 117:7430-7436
Recent progress in deciphering mechanisms of human brain cortical folding leave unexplained whether spatially patterned genetic influences contribute to this folding. High-resolution in vivo brain MRI can be used to estimate genetic correlations (cov
Publikováno v:
Molecular psychiatry. 28(1)
Recently, increasing numbers of rare pathogenic genetic variants have been identified that are associated with variably elevated risks of a range of neurodevelopmental outcomes, notably including Autism Spectrum Disorders (ASD), Schizophrenia Spectru
Autor:
Richard A. I. Bethlehem, Gil D. Hoftman, Wesley K. Thompson, Leanna M. Hernandez, Minsoo Kim, Michael J. Gandal
Publikováno v:
European Neuropsychopharmacology. 51:e72-e73
Autor:
Michael J. Gandal, Minsoo Kim, Gil D. Hoftman, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jillian R. Haney, Leanna M. Hernandez
Publikováno v:
Biological psychiatry, vol 89, iss 1
Biol Psychiatry
Biol Psychiatry
Over the past decade, large-scale genetic studies have successfully identified hundreds of genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic insight -- and clinical translation -- continues to lag the pace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cccfbabe026d38061b602d5bb2364d
https://escholarship.org/uc/item/09h4066r
https://escholarship.org/uc/item/09h4066r
Autor:
Bogdan Pasaniuc, T. Grant Belgard, Sepideh Parhami, Diego de Alba, Neelroop N. Parikshak, Gil D. Hoftman, Gaurav Kale, Ting Jin, Prashant Emani, Ye Emily Wu, Jillian R. Haney, Nathan Chang, Brie Wamsley, Gokul Ramaswami, Daifeng Wang, Mark Gerstein, Vivek Swarup, George T. Chen, Jing Ou, Michael J. Gandal, Christopher Hartl, Daniel H. Geschwind
Classically, psychiatric disorders have been considered to lack defining pathology, but recent work has demonstrated consistent disruption at the molecular level, characterized by transcriptomic and epigenetic alterations.1–3 In ASD, upregulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26f4e611530e97813dedf9715a501d1d
https://doi.org/10.1101/2020.12.17.423129
https://doi.org/10.1101/2020.12.17.423129