Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gil Barzilay"'
Autor:
Loukas Kaklamanis, Adrian L. Harris, S. Kakolyris, Gil Barzilay, Panagiotis Kanavaros, Vassilis Georgoulias, Ian D. Hickson, Kevin C. Gatter, A Giatromanolaki, Michael I. Koukourakis
Publikováno v:
The Journal of Pathology. 189:351-357
The present study examined the immunohistochemical expression of human AP endonuclease 1 (HAP1/Ref-1), the major endonuclease in the repair of apurinic/apyrimidinic (AP) sites in cellular DNA, in normal lung and lung carcinomas. Cellular expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8692ad8f14df5c49f6ac464820dbb90f
https://doi.org/10.1002/(sici)1096-9896(199911)189:3<351::aid-path435>3.0.co
https://doi.org/10.1002/(sici)1096-9896(199911)189:3<351::aid-path435>3.0.co
Autor:
P Kanavaros, K C Gatter, V Georgoulias, Ian D. Hickson, Loukas Kaklamanis, R Leek, Adrian L. Harris, Gil Barzilay, S. Kakolyris, M I Koukourakis, A Giatromanolaki, Helen Turley
Publikováno v:
Histopathology. 33:561-569
Aims: Human AP endonuclease 1 (HAP1) plays a major role in the repair of apurinic/apyrimidinic (AP) sites in cellular DNA by catalysing hydrolytic cleavage of the phosphodiester backbone 5′ to the site. HAP1 is also known to be a potent reduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1187a47ad3b59921c166f7c44425751
https://doi.org/10.1046/j.1365-2559.1998.00541.x
https://doi.org/10.1046/j.1365-2559.1998.00541.x
Autor:
Clifford D. Mol, Lisa J. Walker, Gil Barzilay, John A. Tainer, Richard P. Cunningham, Craig N. Robson, Ian D. Hickson
Publikováno v:
Nature Structural Biology. 2:561-568
All organisms express dedicated repair enzymes for counteracting the cytotoxic and mutagenic potential of apurinic/apyrimidinic (AP) lesions, which would otherwise pose a serious threat to genome integrity. We present the predicted three-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c9d3bf20d506dbb60c587f70f2f482
https://doi.org/10.1038/nsb0795-561
https://doi.org/10.1038/nsb0795-561
Publikováno v:
Nucleic Acids Research. 23:1544-1550
HAP1 protein, the major apurinic/apyrimidinic (AP) endonuclease in human cells, is a member of a homologous family of multifunctional DNA repair enzymes including the Escherichia coli exonuclease III and Drosophila Rrp1 proteins. The most extensively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8b6786e2b5af8f63f97a2c5de45748
https://doi.org/10.1093/nar/23.9.1544
https://doi.org/10.1093/nar/23.9.1544
Autor:
Ian D. Hickson, Gil Barzilay
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 17(8)
The DNA of all species is constantly under threat from both endogenous and exogenous factors, which damage its chemical structure. Probably the most common lesion that arises in cellular DNA is the loss of a base to generate an abasic site, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c64ab7c14e248c850725b9d11b35524
https://pubmed.ncbi.nlm.nih.gov/7661852
https://pubmed.ncbi.nlm.nih.gov/7661852