Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gil Arvatz"'
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Unlike the intense research effort devoted to exploring the significance of heparanase in human diseases, very little attention was given to its close homolog, heparanase 2 (Hpa2). The emerging role of Hpa2 in a rare autosomal recessive congenital di
Externí odkaz:
https://doaj.org/article/9f4f12adb1ec46e8b38974237c3ea6fd
Autor:
Dror Eliaz, Sriram Kannan, Hadassa Shaked, Gil Arvatz, Itai Dov Tkacz, Lior Binder, Hiba Waldman Ben-Asher, Uthman Okalang, Vaibhav Chikne, Smadar Cohen-Chalamish, Shulamit Michaeli
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006245 (2017)
Extracellular vesicles (EV) secreted by pathogens function in a variety of biological processes. Here, we demonstrate that in the protozoan parasite Trypanosoma brucei, exosome secretion is induced by stress that affects trans-splicing. Following per
Externí odkaz:
https://doaj.org/article/6d5be7b6dfff4aee9b63fbe6eef425a2
Autor:
Uri Barash, Gil Arvatz, Roy Farfara, Inna Naroditsky, Ilana Doweck, Sari Feld, Ofer Ben-Izhak, Neta Ilan, Ofer Nativ, Israel Vlodavsky
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51494 (2012)
T5 is a novel splice variant of heparanase, an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains at a limited number of sites. T5 splice variant is endowed with pro-tumorigenic properties, enhancing cell proliferation, anchorage
Externí odkaz:
https://doaj.org/article/55a509a510c44ac3a165a6065e6f2cdb
Autor:
Israel Vlodavsky, Neta Ilan, Inna Naroditsky, Uri Barash, Gil Arvatz, Peleg Hasson, Gera Neufeld, Ilana Doweck, Sari Feld, Miriam Gross-Cohen
Over expression of Hpa2 is associated with increased apoptosis, cytokeratin expression and tumor hypoxia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037e4e0a80666342fc5296f2a0436f09
https://doi.org/10.1158/0008-5472.22411988
https://doi.org/10.1158/0008-5472.22411988
Autor:
Israel Vlodavsky, Neta Ilan, Inna Naroditsky, Uri Barash, Gil Arvatz, Peleg Hasson, Gera Neufeld, Ilana Doweck, Sari Feld, Miriam Gross-Cohen
The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has been implicated strongly in tumor metastasis and angiogenesis. Heparanase-2 (Hpa2) is a close homolog of heparanase that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4f194adb861cc3cb9780ecd0559223
https://doi.org/10.1158/0008-5472.c.6508343.v1
https://doi.org/10.1158/0008-5472.c.6508343.v1
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Frontiers in Oncology
Frontiers in Oncology
Unlike the intense research effort devoted to exploring the significance of heparanase in human diseases, very little attention was given to its close homolog, heparanase 2 (Hpa2). The emerging role of Hpa2 in a rare autosomal recessive congenital di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9306750182e0b58339070677a12013b2
https://www.frontiersin.org/articles/10.3389/fonc.2020.627463/full
https://www.frontiersin.org/articles/10.3389/fonc.2020.627463/full
Autor:
Miriam Gross-Cohen, Sari Feld, Ilana Doweck, Uri Barash, Neta Ilan, Peleg Hasson, Israel Vlodavsky, Gil Arvatz, Inna Naroditsky, Gera Neufeld
Publikováno v:
Cancer Research. 76:2791-2801
The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has been implicated strongly in tumor metastasis and angiogenesis. Heparanase-2 (Hpa2) is a close homolog of heparanase that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8808df66e67a4c881079e93a1fc8b76
https://doi.org/10.1158/0008-5472.can-15-1975
https://doi.org/10.1158/0008-5472.can-15-1975
Autor:
Sari Feld, Eviatar Nevo, Neta Ilan, Marina Weissmann, Netanel A. Horowitz, Israel Vlodavsky, Edward Hammond, Mary Ng, Yi Zhang, Gil Arvatz, Inna Naroditsky
Publikováno v:
Proceedings of the National Academy of Sciences. 113:704-709
Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d1d008645a632fa758785f4d2600cf
https://doi.org/10.1073/pnas.1519453113
https://doi.org/10.1073/pnas.1519453113
Autor:
Avidor Shulman, Tali Kizhner, Yaniv Azulay, David Aviezer, Gil Arvatz, Mariana Hainrichson, Ilya Ruderfer, Yoram Tekoah, Yoseph Shaaltiel
Publikováno v:
Molecular Genetics and Metabolism. 114:259-267
Fabry disease is an X-linked recessive disorder caused by the loss of function of the lysosomal enzyme α-Galactosidase-A. Although two enzyme replacement therapies (ERTs) are commercially available, they may not effectively reverse some of the Fabry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518b8ad0c9f88b3d17aeabcc65d3cfd0
https://doi.org/10.1016/j.ymgme.2014.08.002
https://doi.org/10.1016/j.ymgme.2014.08.002
Autor:
Hiba Waldman Ben-Asher, Lior Binder, Shulamit Michaeli, Gil Arvatz, Vaibhav Chikne, Uthman Okalang, Dror Eliaz, Sriram Kannan, Hadassa Shaked, Smadar Cohen-Chalamish, Itai Dov Tkacz
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006245 (2017)
PLoS Pathogens
PLoS Pathogens
Extracellular vesicles (EV) secreted by pathogens function in a variety of biological processes. Here, we demonstrate that in the protozoan parasite Trypanosoma brucei, exosome secretion is induced by stress that affects trans-splicing. Following per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92511f1123cf47c8b6d1ad3bacd91f1
http://europepmc.org/articles/PMC5352147?pdf=render
http://europepmc.org/articles/PMC5352147?pdf=render