Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts

Autor: Fischer, Suzanne, Creytens, David, Gijsels, Stefanie, Descamps, Benedicte, Lapeire, Lore, Hendrix, An, Sys, Gwen, De Wever, Olivier

Publikováno v: In STAR Protocols 15 March 2024 5(1)

Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties.

Autor: Vermeulen S; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent, Ghent, Belgium., Ernst S; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Experimental Surgery Lab, Department of Human Structure and Repair, Ghent University, Ghent, Belgium., Blondeel E; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent, Ghent, Belgium., Xia Z; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent, Ghent, Belgium., Rappu P; Department of Biochemistry, University of Turku, Turku, Finland., Heino J; Department of Biochemistry, University of Turku, Turku, Finland., Dedeyne S; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent, Ghent, Belgium., Denys H; Cancer Research Institute Ghent, Ghent, Belgium.; Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium., Sys G; Cancer Research Institute Ghent, Ghent, Belgium.; Department of Orthopedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium., Gijsels S; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent, Ghent, Belgium., Depypere H; Cancer Research Institute Ghent, Ghent, Belgium.; Department of Gynecology, Ghent University Hospital, Ghent, Belgium., Tummers P; Cancer Research Institute Ghent, Ghent, Belgium.; Department of Gynecology, Ghent University Hospital, Ghent, Belgium., Ceelen W; Cancer Research Institute Ghent, Ghent, Belgium.; Experimental Surgery Lab, Department of Human Structure and Repair, Ghent University, Ghent, Belgium., Craciun L; Cerba Path, Division CMP, Brussels, Belgium., Demetter P; Cerba Path, Division CMP, Brussels, Belgium., Raes O; Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium., Hendrix A; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent, Ghent, Belgium., Van der Eycken J; Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium., De Wever O; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium. Olivier.dewever@ugent.be.; Cancer Research Institute Ghent, Ghent, Belgium. Olivier.dewever@ugent.be.

Publikováno v: Scientific reports [Sci Rep] 2024 Dec 04; Vol. 14 (1), pp. 30188. Date of Electronic Publication: 2024 Dec 04.