Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Gijs R. van den Brink"'
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
Autor:
Jonathan H. M. van der Meer, Ruben J. de Boer, Bartolomeus J. Meijer, Wouter L. Smit, Jacqueline L. M. Vermeulen, Sander Meisner, Manon van Roest, Pim J. Koelink, Evelien Dekker, Theodorus B. M. Hakvoort, Jan Koster, Lukas J. A. C. Hawinkels, Jarom Heijmans, Eduard A. Struijs, Marja A. Boermeester, Gijs R. van den Brink, Vanesa Muncan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Abstract The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS
Externí odkaz:
https://doaj.org/article/71fe891b64fe490ab76705ba74a38453
Autor:
Bartolomeus J. Meijer, Wouter L. Smit, Pim J. Koelink, Barbara F. Westendorp, Ruben J. de Boer, Jonathan H. M. van der Meer, Jacqueline L. M. Vermeulen, James C. Paton, Adrienne W. Paton, Jun Qin, Evelien Dekker, Vanesa Muncan, Gijs R. van den Brink, Jarom Heijmans
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Enforcing differentiation of cancer stem cells is considered as a potential strategy to sensitize colorectal cancer cells to irradiation and chemotherapy. Activation of the unfolded protein response, due to endoplasmic reticulum (ER) stress,
Externí odkaz:
https://doaj.org/article/24ebfc27c3394013a484ca3d122122e9
Autor:
Bartolomeus J. Meijer, Francesca P. Giugliano, Bart Baan, Jonathan H.M. van der Meer, Sander Meisner, Manon van Roest, Pim J. Koelink, Ruben J. de Boer, Nic Jones, Wolfgang Breitwieser, Nicole N. van der Wel, Manon E. Wildenberg, Gijs R. van den Brink, Jarom Heijmans, Vanesa Muncan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 23-42 (2020)
Background & Aims: Activation factor-1 transcription factor family members activating transcription factors 2 and 7 (ATF2 and ATF7) have highly redundant functions owing to highly homologous DNA binding sites. Their role in intestinal epithelial home
Externí odkaz:
https://doaj.org/article/5ca26a8b84574534a05a42331734351c
Autor:
Paula S. Montenegro-Miranda, Jonathan H.M. van der Meer, Christine Jones, Sander Meisner, Jacqueline L.M. Vermeulen, Jan Koster, Manon E. Wildenberg, Jarom Heijmans, Francois Boudreau, Agnes Ribeiro, Gijs R. van den Brink, Vanesa Muncan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 209-223 (2020)
Background & Aims: Recent evidence has suggested that the intact intestinal epithelial barrier protects our body from a range of immune-mediated diseases. The epithelial layer has an impressive ability to reconstitute and repair upon damage and this
Externí odkaz:
https://doaj.org/article/db3b9d77df664ad1a00688f596d26314
Autor:
Ivo S. Hansen, Lisette Krabbendam, Jochem H. Bernink, Fabricio Loayza-Puch, Willianne Hoepel, Johan A. van Burgsteden, Elsa C. Kuijper, Christianne J. Buskens, Willem A. Bemelman, Sebastiaan A. J. Zaat, Reuven Agami, Gestur Vidarsson, Gijs R. van den Brink, Esther C. de Jong, Manon E. Wildenberg, Dominique L. P. Baeten, Bart Everts, Jeroen den Dunnen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dendritic cells (DC) are important for maintaining immune homeostasis in the gut, but how they promote intestinal inflammation upon bacterial infection is still unclear. Here the authors show that IgA immune complexes induce proinflammatory cytokine
Externí odkaz:
https://doaj.org/article/292a58835f16458d974a1336ef0a74da
Autor:
Marco Gerling, Nikè V. J. A. Büller, Leonard M. Kirn, Simon Joost, Oliver Frings, Benjamin Englert, Åsa Bergström, Raoul V. Kuiper, Leander Blaas, Mattheus C. B. Wielenga, Sven Almer, Anja A. Kühl, Erik Fredlund, Gijs R. van den Brink, Rune Toftgård
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated w
Externí odkaz:
https://doaj.org/article/3935658324894f5a9a9d4187bc7ac949
Autor:
Olga N. Karpus, B. Florien Westendorp, Jacqueline L.M. Vermeulen, Sander Meisner, Jan Koster, Vanesa Muncan, Manon E. Wildenberg, Gijs R. van den Brink
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3698-3708.e5 (2019)
Summary: Intestinal epithelial cells have a defined hierarchy with stem cells located at the bottom of the crypt and differentiated cells more at the top. Epithelial cell renewal and differentiation are strictly controlled by various regulatory signa
Externí odkaz:
https://doaj.org/article/615b6f5c56174a89a8afa3f086733b37
Autor:
Mattheus C.B. Wielenga, Selcuk Colak, Jarom Heijmans, Jooske F. van Lidth de Jeude, Hans M. Rodermond, James C. Paton, Adrienne W. Paton, Louis Vermeulen, Jan Paul Medema, Gijs R. van den Brink
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 489-494 (2015)
Colon cancer stem cells (colon-CSCs) are more resistant to conventional chemotherapy than differentiated cancer cells. This subset of therapy refractory cells is therefore believed to play an important role in post-therapeutic tumor relapse. In order
Externí odkaz:
https://doaj.org/article/86d9380850ce4b839880c31d6b8772ed
Autor:
B. Florien Westendorp, Nikè V.J.A. Büller, Olga N. Karpus, Willemijn A. van Dop, Jan Koster, Rogier Versteeg, Pim J. Koelink, Clinton Y. Snel, Sander Meisner, Joris J.T.H. Roelofs, Anja Uhmann, Emiel Ver Loren van Themaat, Jarom Heijmans, Heidi Hahn, Vanesa Muncan, Manon E. Wildenberg, Gijs R. van den Brink
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 67-82.e1 (2018)
Upon intestinal epithelial damage a complex wound healing response is initiated to restore epithelial integrity and defend against pathogenic invasion. Epithelium-derived Indian Hedgehog (Ihh) functions as a critical sensor in this process. Signaling
Externí odkaz:
https://doaj.org/article/9d4a94cb2a704ae8b3fc61b771fff5f4
Autor:
Jarom Heijmans, Jooske F. van Lidth de Jeude, Bon-Kyoung Koo, Sanne L. Rosekrans, Mattheus C.B. Wielenga, Marc van de Wetering, Marc Ferrante, Amy S. Lee, Jos J.M. Onderwater, James C. Paton, Adrienne W. Paton, A. Mieke Mommaas, Liudmila L. Kodach, James C. Hardwick, Daniël W. Hommes, Hans Clevers, Vanesa Muncan, Gijs R. van den Brink
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1128-1139 (2013)
Stem cells generate rapidly dividing transit-amplifying cells that have lost the capacity for self-renewal but cycle for a number of times until they exit the cell cycle and undergo terminal differentiation. We know very little of the type of signals
Externí odkaz:
https://doaj.org/article/3c344ff636f84bbcbddc65ce1fcc2e7b