Výsledky vyhledávání - "Gijs H. M. van Puijvelde"

Akademický článek

IFNγ-Stimulated B Cells Inhibit T Follicular Helper Cells and Protect Against Atherosclerosis

Autor: Hidde Douna, J. de Mol, Jacob Amersfoort, Frank H. Schaftenaar, Mate G. Kiss, Bianca E. Suur, Mara J. Kroner, Christoph J. Binder, Ilze Bot, Gijs H. M. Van Puijvelde, Johan Kuiper, Amanda C. Foks

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

B and T cells are interconnected in the T follicular helper—germinal center B cell (TFH-GC B cell) axis, which is hyperactive during atherosclerosis development and loss of control along this axis results in exacerbated atherosclerosis. Inhibition

Externí odkaz: https://doaj.org/article/b7e329b21fe3497880611ebc48962b59

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Akademický článek

Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis

Autor: Jacob Amersfoort, Hidde Douna, Frank H. Schaftenaar, Amanda C. Foks, Mara J. Kröner, Peter J. van Santbrink, Gijs H. M. van Puijvelde, Ilze Bot, Johan Kuiper

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Macroautophagy (or autophagy) is a conserved cellular process in which cytoplasmic cargo is targeted for lysosomal degradation. Autophagy is crucial for the functional integrity of different subsets of T cells in various developmental stages. Since a

Externí odkaz: https://doaj.org/article/8cd87af9006544a1af0eb617c945cff4

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Akademický článek

CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice.

Autor: Gijs H M van Puijvelde, Amanda C Foks, Rosemarie E van Bochove, Ilze Bot, Kim L L Habets, Saskia C de Jager, Mariëtte N D Ter Borg, Puck van Osch, Louis Boon, Mariska Vos, Vivian de Waard, Johan Kuiper

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190962 (2018)

An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important fa

Externí odkaz: https://doaj.org/article/2ef143ea6d7b40768aea73f7394d8ed1

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Akademický článek

Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development.

Autor: Amanda C Foks, Ingrid A Ran, Vanessa Frodermann, Ilze Bot, Peter J van Santbrink, Johan Kuiper, Gijs H M van Puijvelde

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83134 (2013)

OBJECTIVE: Co-stimulatory and co-inhibitory molecules are mainly expressed on T cells and antigen presenting cells and strongly orchestrate adaptive immune responses. Whereas co-stimulatory molecules enhance immune responses, signaling via co-inhibit

Externí odkaz: https://doaj.org/article/f17c6e22f03242b090de700ba9fdc60e

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Bidirectional effects of IL-10

Autor: Hidde, Douna, Jacob, Amersfoort, Frank H, Schaftenaar, Sanne, Kroon, Gijs H M, van Puijvelde, Johan, Kuiper, Amanda C, Foks

Publikováno v: Atherosclerosis. 280

Limiting the pro-inflammatory immune response is critical for the treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65e06d60dd290b1c0a44467942691121
https://pubmed.ncbi.nlm.nih.gov/30500604

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