Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gijs G, Zom"'
Autor:
Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük, Katy Lloyd, Vitalijs Ovcinnikovs, Gijs G. Zom, Renoud J. Marijnissen, Christianne Groeneveldt, Lisa Griffioen, Gerwin G. W. Sandker, Sandra Heskamp, Sjoerd H. van der Burg, Tsolere Arakelian, Ferry Ossendorp, Ramon Arens, Janine Schuurman, Kristel Kemper, Thorbald van Hall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CD3 bispecific antibody (CD3 bsAb) therapy is clinically approved for refractory hematological malignancies, but responses in solid tumors have been limited so far. One of the main hurdles in solid tumors is the lack of sufficient T-cell inf
Externí odkaz:
https://doaj.org/article/36795cab2cda485e96053669065dc63a
Autor:
Hans Gelderblom, Sjoerd H van der Burg, Ferry Ossendorp, Peggy J de Vos van Steenwijk, Mariette I E van Poelgeest, Inge Roozen, Willem-Jan Krebber, Cornelis J M Melief, Frank M Speetjens, Marij J P Welters, Nikki M Loof, Sanne Boekestijn, Catharina A H Janssen, Marije Slingerland, Gijs G Zom, A Rob P M Valentijn, Nico J Meeuwenoord, Gijs A van der Marel, Dmitri V Filippov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background Amplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models, amplivant-adjuvanted synthetic long peptides (SLPs) strongly enhanced antigen presentation
Externí odkaz:
https://doaj.org/article/116d0102ba984134b3b45409c8b1b84b
Autor:
Gijs G. Zom, Marian M. J. H. P. Willems, Selina Khan, Tetje C. van der Sluis, Jan Willem Kleinovink, Marcel G. M. Camps, Gijsbert A. van der Marel, Dmitri V. Filippov, Cornelis J. M. Melief, Ferry Ossendorp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Background Ligands for the Toll-like receptor (TLR) family can induce activation of cells of the innate immune system and are widely studied for their potential to enhance adaptive immunity. Conjugation of TLR2-ligand Pam3CSK4 to synthetic l
Externí odkaz:
https://doaj.org/article/709a690ddcf245d583864fadeb597229
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Autor:
Ferry Ossendorp, Cornelis J.M. Melief, Hermen S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov, Nico J. Meeuwenoord, Christina F. Budden, Nikki M. Loof, Marcel G.M. Camps, Vinod Sommandas, Cedrik M. Britten, Selina Khan, Gijs G. Zom
Chemical conjugates comprising synthetic Toll-like receptor ligands (TLR-L) covalently bound to antigenic synthetic long peptides (SLP) are attractive vaccine modalities, which can induce robust CD8+ T-cell immune responses. Previously, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1445c8e619d7dc1d47cd3adb1f435024
https://doi.org/10.1158/2326-6066.c.6548485.v1
https://doi.org/10.1158/2326-6066.c.6548485.v1
Autor:
Ferry Ossendorp, Cornelis J.M. Melief, Hermen S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov, Nico J. Meeuwenoord, Christina F. Budden, Nikki M. Loof, Marcel G.M. Camps, Vinod Sommandas, Cedrik M. Britten, Selina Khan, Gijs G. Zom
PDF file - 266K, Supplementary figure 1. DC maturation by TLR2-L SLP conjugates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279829d536ce226db78aea70f311db88
https://doi.org/10.1158/2326-6066.22537588.v1
https://doi.org/10.1158/2326-6066.22537588.v1
Autor:
Ferry Ossendorp, Cornelis J.M. Melief, Hermen S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov, Nico J. Meeuwenoord, Christina F. Budden, Nikki M. Loof, Marcel G.M. Camps, Vinod Sommandas, Cedrik M. Britten, Selina Khan, Gijs G. Zom
PDF file - 89K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed5ca3fb207eac28f33bcbb7b09cb5d
https://doi.org/10.1158/2326-6066.22537579.v1
https://doi.org/10.1158/2326-6066.22537579.v1
Autor:
Ferry Ossendorp, Cornelis J.M. Melief, Hermen S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov, Nico J. Meeuwenoord, Christina F. Budden, Nikki M. Loof, Marcel G.M. Camps, Vinod Sommandas, Cedrik M. Britten, Selina Khan, Gijs G. Zom
PDF file - 679K, Supplementary figure 2. In vitro T-cell activation induced by conjugated SLP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b688fe6c2bfbb8bad7a6ceca06536b8
https://doi.org/10.1158/2326-6066.22537585
https://doi.org/10.1158/2326-6066.22537585
Autor:
Marian M. J. H. P. Willems, Gijs G. Zom, Nico Meeuwenoord, Ferry A. Ossendorp, Herman S. Overkleeft, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1445-1453 (2014)
The covalent attachment of an innate immune system stimulating agent to an antigen can provide active vaccine modalities capable of eliciting a potent immune response against the incorporated antigen. Here we describe the design, automated synthesis
Externí odkaz:
https://doaj.org/article/8ba07bdc89314fe592a28a8770e53ec6
Autor:
Herman S. Overkleeft, Ferry Ossendorp, Selina Khan, Nico J. Meeuwenoord, Niels R. M. Reintjens, Gijsbert A. van der Marel, Jeroen D. C. Codée, Gijs G. Zom, Dmitri V. Filippov, Marian M. J. H. P. Willems, Elena Tondini
Publikováno v:
Bioconjugate Chemistry
Bioconjugate Chemistry, 30(4), 1150-1161
Bioconjugate Chemistry, 30(4), 1150-1161
Simultaneous triggering of Toll-like receptors (TLRs) and NOD-like receptors (NLRs) has previously been shown to synergistically activate monocytes, dendritic cells and macrophages. We applied these properties in a T-cell vaccine setting by conjugati