Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gijo George"'
Autor:
DRGKoppalu R. Puneeth Kumar, Rahi M. Reja, Dillip K. Senapati, Manjeet Singh, Sachin A. Nalawade, Gijo George, Grace Kaul, Abdul Akhir, Sidharth Chopra, Srinivasarao Raghothama, Hosahudya N. Gopi
Publikováno v:
RSC Medicinal Chemistry. 14:332-340
A cationic amphiphilic peptide effectively prevents the aggregation of soluble Aβ42 and also disintegrates matured fibrils into soluble precursors. In addition, the peptide also rescues cells from the toxicity of Aβ42.
Autor:
Vivek Kumar, Gijo George, DRGKoppalu R. Puneeth Kumar, Rahi M. Reja, Hosahudya N. Gopi, Rajat Patel, Srinivasarao Raghothama
Publikováno v:
Chemistry – A European Journal. 26:4304-4309
Due to their equivalent lengths, I´-amino acids can serve as surrogates of I±-dipeptides. However, I´-amino acids with proteinogenic side chains have not been well studied because of synthetic difficulties and because of their insolubility in orga
Publikováno v:
Chemistry – An Asian Journal. 14:4408-4414
Molecular chirality is ubiquitous in nature. The natural biopolymers, proteins and DNA, preferred a right-handed helical bias due to the inherent stereochemistry of the monomer building blocks. Here, we are reporting a rare co-existence of left- and
Autor:
Rajkumar Misra, Hosahudya N. Gopi, Gijo George, Srinivasarao Raghothama, Sanjit Dey, Rahi M. Reja
Publikováno v:
Chemical Communications. 56:2171-2173
Unique ε-helical organizations (11-helices) from β,γ-hybrid peptides composed of chiral β3-amino acids along with achiral 3,3- or 4,4-dimethyl substituted γ-amino acids are disclosed.
Autor:
Rahi M, Reja, Vivek, Kumar, Gijo, George, Rajat, Patel, DRGKoppalu R, Puneeth Kumar, Srinivasarao, Raghothama, Hosahudya N, Gopi
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 26(19)
Due to their equivalent lengths, δ-amino acids can serve as surrogates of α-dipeptides. However, δ-amino acids with proteinogenic side chains have not been well studied because of synthetic difficulties and because of their insolubility in organic
Autor:
Rajkumar Misra, Gijo George, Hosahudya N. Gopi, Rahi M. Reja, Lagumaddepalli V. Narendra, Srinivasarao Raghothama
Publikováno v:
Chemical Communications. 52:9597-9600
We are reporting the influence of foldamer structures on their self-assembled architectures. In a sharp contrast to the ordered α,γ-hybrid 12-helix obtained from 1 : 1 alternating Aib and γ-Phe, the α,γ-hybrid peptides constituted with α-Phe an
Publikováno v:
Chemical Physics Letters. 627:126-129
Longitudinal relaxation due to cross-correlation between dipolar ((HN-1H alpha)-H-1) and amide-proton chemical shift anisotropy (H-1(N) CSA) has been measured in a model tripeptide Piv-(L)Pro-(L)Pro-(L)Phe-OMe. The peptide bond across diproline segme
Autor:
Rajkumar Misra, K. Muruga Poopathi Raja, Hans-Joerg Hofmann, Hosahudya N. Gopi, Gijo George, Kuruva Veeresh, Abhijith Saseendran, Srinivasarao Raghothama
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(15)
Here, novel 12-helices in α,γ-hybrid peptides composed of achiral α-aminoisobutyric acid (Aib) and 4-aminoisocaproic acid (Aic, doubly homologated Aib) monomers in 1:1 alternation are reported. The 12-helices were indicated by solution and crystal
Autor:
Snehasish Ghosh, Rituparna Sinha Roy, Srinivasarao Raghothama, Souvik Dey, Gijo George, Chiranjit Dutta, Dhananjay Bhattacharyya, Sanchita Mukherjee, Kasturee Chakraborty, Paramita Gayen, Abhijit Biswas
Publikováno v:
Advanced Therapeutics. 1:1870022