Zobrazeno 1 - 3
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pro vyhledávání: '"Giimel Ajnai"'
Autor:
Giimel Ajnai, Chun-Chia Cheng, Tzu-Chun Kan, Jeng-Wei Lu, Sri Rahayu, Amy Chiu, Jungshan Chang
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 847 (2022)
Tumor hypoxia is a hallmark of solid tumors and emerged as the therapeutic target for cancer treatments, such as a prodrug Tirapazamine (TPZ) activated in hypoxia. To increase tumor accumulation, gold nanoparticles (GNPs) were selected to conjugate w
Externí odkaz:
https://doaj.org/article/aad744552299478a892f4cfecdeccfa4
Publikováno v:
Journal of Experimental & Clinical Medicine. 6:172-178
Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6743530bf94ad6c0dd0efbdeb1d6768d
https://doi.org/10.1016/j.jecm.2014.10.015
https://doi.org/10.1016/j.jecm.2014.10.015
Publikováno v:
Free Radical Biology and Medicine. 108:S46
Tirapazamine (TPZ) has been considered as a therapeutic candidate for cancers in the future. It selectively activates multiple reductases to release free radicals from hypoxic cells such as cancer cells, leading to DNA damages and cell death. This un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23306d262ec0b959f7fe46313f6a5457
https://doi.org/10.1016/j.freeradbiomed.2017.04.169
https://doi.org/10.1016/j.freeradbiomed.2017.04.169