Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Giichi Takaesu"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94982 (2014)
Macrophages play diverse roles in tissue homeostasis and immunity, and canonically activated macrophages are critically associated with acute inflammatory responses. It is known that activated macrophages undergo cell death after transient activation
Externí odkaz:
https://doaj.org/article/32ddf83edec040e9b64ee154f41baa1e
Autor:
Giichi Takaesu, Maiko Inagaki, Keiyo Takubo, Yuji Mishina, Paul R Hess, Gregg A Dean, Akihiko Yoshimura, Kunihiro Matsumoto, Toshio Suda, Jun Ninomiya-Tsuji
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e51073 (2012)
A cytokine/stress signaling kinase Tak1 (Map3k7) deficiency is known to impair hematopoietic progenitor cells. However, the role of TAK1 signaling in the stem cell function of the hematopoietic system is not yet well defined. Here we characterized he
Externí odkaz:
https://doaj.org/article/6b707aa788c14c03ae9c4216e9ae859f
Autor:
Tomomi Kurane, Tetsuro Matsunaga, Tomoaki Ida, Kazuko Sawada, Akira Nishimura, Masayuki Fukui, Masayuki Umemura, Masaaki Nakayama, Naoya Ohara, Sohkichi Matsumoto, Takaaki Akaike, Goro Matsuzaki, Giichi Takaesu
Publikováno v:
The FASEB Journal. 36
Autor:
Hirofumi Matsumoto, Takahiro Goto, Tessho Maruyama, Goro Matsuzaki, Kazuhide Nishihara, Masato Umikawa, Giichi Takaesu, Akira Arasaki, Toshiyuki Nakasone, Fusahiro Hirano, Hiroyuki Nakamura, Akira Matayoshi, Nobuyuki Maruyama
Publikováno v:
Anticancer research. 40(11)
Background/aim Oral squamous cell carcinoma (OSCC) is a common malignancy with poor prognosis. Therefore, novel therapeutic options are needed to improve prognosis of OSCC. Recently, microRNAs (miRs) have received increasing attention as a potential
Autor:
Claudia Toma, Tetsu Yamashiro, Naomi Higa, Toshihiko Suzuki, Yukiko Koizumi, Yasunori Ogura, Giichi Takaesu, Noboru Nakasone
Publikováno v:
Microbiology and Immunology. 62:444-453
We screened a total of 672 plant-tissue extracts to search for phytochemicals that inhibit the function of the type III secretion system (T3SS) of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). Among candidates examine
Autor:
Noboru, Nakasone, Yasunori, Ogura, Naomi, Higa, Claudia, Toma, Yukiko, Koizumi, Giichi, Takaesu, Toshihiko, Suzuki, Tetsu, Yamashiro
Publikováno v:
Microbiology and immunology.
We screened a total of 672 plant-tissue extracts to search for phytochemicals that inhibit the function of the type III secretion system (T3SS) of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). Among candidates examine
Autor:
Emily Omori, Jun Ninomiya-Tsuji, Yuka Ikeda, Sho Morioka, Giichi Takaesu, Peter Broglie, Kunihiro Matsumoto
Publikováno v:
The Journal of Cell Biology
Activation of the TAK1 kinase drives RIPK3-dependent necrosis and inhibits apoptosis downstream of TNF-α stimulation.
TNF activates three distinct intracellular signaling cascades leading to cell survival, caspase-8–mediated apoptosis, or rec
TNF activates three distinct intracellular signaling cascades leading to cell survival, caspase-8–mediated apoptosis, or rec
Autor:
Michael B. Fessler, Yosuke Sakamachi, September R. Mihaly, Jun Ninomiya-Tsuji, Giichi Takaesu, Sho Morioka, Julie F. Foley
Publikováno v:
Cell Death & Disease
Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specif
Publikováno v:
Proceedings of the National Academy of Sciences. 110:18844-18849
The autophagic ubiquitin-like protein (ublp) autophagy-related (ATG)12 is a component of the ATG12∼ATG5-ATG16L1 E3 complex that promotes lipid conjugation of members of the LC3 ublp family. A role of ATG12 in the E3 complex is to recruit the E2 enz
Publikováno v:
Nature structural & molecular biology
The autophagy factor ATG12~ATG5 conjugate exhibits E3 ligase-like activity which facilitates the lipidation of members of the LC3 family. The crystal structure of the human ATG12~ATG5 conjugate bound to the N-terminal region of ATG16L1, the factor th