Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gihan S Gunaratne"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006420 (2018)
The anthelmintic praziquantel (±PZQ) serves as a highly effective antischistosomal therapy. ±PZQ causes a rapid paralysis of adult schistosome worms and deleterious effects on the worm tegument. In addition to these activities against the parasite,
Externí odkaz:
https://doaj.org/article/7ba0fa2650e74ed68794d612ce6f95d2
Publikováno v:
Bioorganicmedicinal chemistry. 76
A photo-clickable analog of adenosine was devised and synthesized in which the photoactive functional group (8-azidoadenosine) and the click moiety (2'-O-propargyl-ether) were compactly combined within the structure of the adenosine nucleoside itself
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::025afb92b9a6a85187ca65b69194b08c
https://pubmed.ncbi.nlm.nih.gov/36446271
https://pubmed.ncbi.nlm.nih.gov/36446271
Autor:
Mohammad A. Rashid, Yaping Lin-Moshier, Gihan S. Gunaratne, Sreya Subramanian, Jonathan S. Marchant, Veedamali S. Subramanian
Publikováno v:
International Journal of Biological Macromolecules. 230:123205
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db644d96de2168f7e5999b42361d73c9
https://doi.org/10.1016/j.ijbiomac.2023.123205
https://doi.org/10.1016/j.ijbiomac.2023.123205
Publikováno v:
Cell Calcium
Two-pore channels are ancient members of the voltage-gated ion channel superfamily that are expressed predominantly on acidic organelles such as endosomes and lysosomes. Here we review recent advances in understanding how TPCs are activated by their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b684846aee53d7bb996be4964955ed10
https://pubmed.ncbi.nlm.nih.gov/35123238
https://pubmed.ncbi.nlm.nih.gov/35123238
Publikováno v:
Bioorganic & Medicinal Chemistry. 76:117099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d8dcc411ace9326aca7ebe6ec403dd
https://doi.org/10.1016/j.bmc.2022.117099
https://doi.org/10.1016/j.bmc.2022.117099
Publikováno v:
Trends Biochem Sci
Trends in biochemical sciences, vol 47, iss 3
Trends in biochemical sciences, vol 47, iss 3
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from endosomes and lysosomes by activating ion channels called two-pore channels (TPCs). However, no NAADP-binding site has been identified on TPCs. Rath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a0a20d5d6bd2827a36b456a4aa29fd
https://europepmc.org/articles/PMC8840967/
https://europepmc.org/articles/PMC8840967/
Autor:
Obinna C. Ubah, Eric W. Lake, Gihan S. Gunaratne, Joseph P. Gallant, Marie Fernie, Austin J. Robertson, Jonathan S. Marchant, Tyler D. Bold, Ryan A. Langlois, William E. Matchett, Joshua M. Thiede, Ke Shi, Lulu Yin, Nicholas H. Moeller, Surajit Banerjee, Laura Ferguson, Marina Kovaleva, Andrew J. Porter, Hideki Aihara, Aaron M. LeBeau, Caroline J. Barelle
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Single-domain Variable New Antigen Receptors (VNARs) from the immune system of sharks are the smallest naturally occurring binding domains found in nature. Possessing flexible paratopes that can recognize protein motifs inaccessible to classical anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e3e42cbfec3e27a12039bf347422d2
https://pubmed.ncbi.nlm.nih.gov/34916516
https://pubmed.ncbi.nlm.nih.gov/34916516
Autor:
Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant
Publikováno v:
iScience
iScience, Vol 25, Iss 1, Pp 103706-(2022)
iScience, Vol 25, Iss 1, Pp 103706-(2022)
Summary Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795472bba993a0e44b2af6a537019438
https://pubmed.ncbi.nlm.nih.gov/35059610
https://pubmed.ncbi.nlm.nih.gov/35059610
Publikováno v:
Biochim Biophys Acta Mol Cell Res
Nicotinic acid adenine dinucleotide phosphate is an evolutionarily conserved second messenger, which mobilizes Ca(2+) from acidic stores. The molecular identity of the NAADP receptor has yet to be defined. In pursuit of isolating and identifying NAAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7f81cae9365da44513e98bd1385dc
https://doi.org/10.1016/j.bbamcr.2018.11.017
https://doi.org/10.1016/j.bbamcr.2018.11.017
Autor:
Timothy F. Walseth, Sandip Patel, Ellen M. Unterwald, Eugen Brailoiu, Shijun He, Gihan S. Gunaratne, James T. Slama, Jonathan S. Marchant
Publikováno v:
Sci Signal
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from acidic organelles through the activation of two pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action is mediated by NAADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7445918735db09e2fd440943130b69
https://doi.org/10.1126/scisignal.abd5605
https://doi.org/10.1126/scisignal.abd5605