Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gihan S, Gunaratne"'
Autor:
Obinna C. Ubah, Eric W. Lake, Gihan S. Gunaratne, Joseph P. Gallant, Marie Fernie, Austin J. Robertson, Jonathan S. Marchant, Tyler D. Bold, Ryan A. Langlois, William E. Matchett, Joshua M. Thiede, Ke Shi, Lulu Yin, Nicholas H. Moeller, Surajit Banerjee, Laura Ferguson, Marina Kovaleva, Andrew J. Porter, Hideki Aihara, Aaron M. LeBeau, Caroline J. Barelle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Shark antibodies (Variable New Antigen Receptors, VNARs) are the smallest naturally occurring antibody fragments. Here, the authors screen a VNAR phage display library against the SARS-CoV2 receptor binding domain (RBD) and identify VNARs that neutra
Externí odkaz:
https://doaj.org/article/d533a0ef137944a582f18b4def8a849b
Autor:
Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103706- (2022)
Summary: Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, ar
Externí odkaz:
https://doaj.org/article/94f636ca50da4ffaa3d30ac7bc2841a5
Autor:
Malika Arhatte, Gihan S. Gunaratne, Charbel El Boustany, Ivana Y. Kuo, Céline Moro, Fabrice Duprat, Magali Plaisant, Hélène Duval, Dahui Li, Nicolas Picard, Anais Couvreux, Christophe Duranton, Isabelle Rubera, Sophie Pagnotta, Sandra Lacas-Gervais, Barbara E. Ehrlich, Jonathan S. Marchant, Aaron M. Savage, Fredericus J. M. van Eeden, Robert N. Wilkinson, Sophie Demolombe, Eric Honoré, Amanda Patel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that del
Externí odkaz:
https://doaj.org/article/a10e8cca0f764891af20836abbb4891c
Autor:
John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor
Externí odkaz:
https://doaj.org/article/562739954b0b4cf0ad3e903c389b980c
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006420 (2018)
The anthelmintic praziquantel (±PZQ) serves as a highly effective antischistosomal therapy. ±PZQ causes a rapid paralysis of adult schistosome worms and deleterious effects on the worm tegument. In addition to these activities against the parasite,
Externí odkaz:
https://doaj.org/article/7ba0fa2650e74ed68794d612ce6f95d2
Publikováno v:
Bioorganicmedicinal chemistry. 76
A photo-clickable analog of adenosine was devised and synthesized in which the photoactive functional group (8-azidoadenosine) and the click moiety (2'-O-propargyl-ether) were compactly combined within the structure of the adenosine nucleoside itself
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::025afb92b9a6a85187ca65b69194b08c
https://pubmed.ncbi.nlm.nih.gov/36446271
https://pubmed.ncbi.nlm.nih.gov/36446271
Autor:
Mohammad A. Rashid, Yaping Lin-Moshier, Gihan S. Gunaratne, Sreya Subramanian, Jonathan S. Marchant, Veedamali S. Subramanian
Publikováno v:
International Journal of Biological Macromolecules. 230:123205
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db644d96de2168f7e5999b42361d73c9
https://doi.org/10.1016/j.ijbiomac.2023.123205
https://doi.org/10.1016/j.ijbiomac.2023.123205
Publikováno v:
Cell Calcium
Two-pore channels are ancient members of the voltage-gated ion channel superfamily that are expressed predominantly on acidic organelles such as endosomes and lysosomes. Here we review recent advances in understanding how TPCs are activated by their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b684846aee53d7bb996be4964955ed10
https://pubmed.ncbi.nlm.nih.gov/35123238
https://pubmed.ncbi.nlm.nih.gov/35123238
Publikováno v:
Bioorganic & Medicinal Chemistry. 76:117099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d8dcc411ace9326aca7ebe6ec403dd
https://doi.org/10.1016/j.bmc.2022.117099
https://doi.org/10.1016/j.bmc.2022.117099
Publikováno v:
Trends Biochem Sci
Trends in biochemical sciences, vol 47, iss 3
Trends in biochemical sciences, vol 47, iss 3
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from endosomes and lysosomes by activating ion channels called two-pore channels (TPCs). However, no NAADP-binding site has been identified on TPCs. Rath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a0a20d5d6bd2827a36b456a4aa29fd
https://europepmc.org/articles/PMC8840967/
https://europepmc.org/articles/PMC8840967/
