Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gigi C.G. Choi"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100255- (2021)
Summary: The CRISPR-Cas system coupled with Combinatorial Genetics En Masse (CombiGEM) enables systematic analysis of high-order genetic perturbations that are important for understanding biological processes and discovering therapeutic target combin
Externí odkaz:
https://doaj.org/article/da7c838154bc4567a61d5c77cbc1f2ac
Autor:
Peng Zhou, Becky K.C. Chan, Yuk Kei Wan, Chaya T.L. Yuen, Gigi C.G. Choi, Xinran Li, Cindy S.W. Tong, Sophia S.W. Zhong, Jieran Sun, Yufan Bao, Silvia Y.L. Mak, Maggie Z.Y. Chow, Jien Vei Khaw, Suet Yi Leung, Zongli Zheng, Lydia W.T. Cheung, Kaeling Tan, Koon Ho Wong, H.Y. Edwin Chan, Alan S.L. Wong
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108020- (2020)
Summary: We present a CRISPR-based multi-gene knockout screening system and toolkits for extensible assembly of barcoded high-order combinatorial guide RNA libraries en masse. We apply this system for systematically identifying not only pairwise but
Externí odkaz:
https://doaj.org/article/24174da9c12342599b0cf0c61b4eb1cd
Autor:
Alan S.L. Wong, Stephanie Ma, Gigi C.G. Choi, Koon Ho Wong, Yuanhua Huang, Lakhansing Pardeshi, Kylie Hin-Man Mak, Maggie S.H. Cheung, John H.C. Fong, Tin Lok Wong, Hoi Yee Chu, Becky K.C. Chan, Cindy S.W. Tong, Man Tong, Feng Xu
Supplementary Table S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2fbf70b91d62d1d046631237229687
https://doi.org/10.1158/0008-5472.22430379.v1
https://doi.org/10.1158/0008-5472.22430379.v1
Autor:
Alan S.L. Wong, Stephanie Ma, Gigi C.G. Choi, Koon Ho Wong, Yuanhua Huang, Lakhansing Pardeshi, Kylie Hin-Man Mak, Maggie S.H. Cheung, John H.C. Fong, Tin Lok Wong, Hoi Yee Chu, Becky K.C. Chan, Cindy S.W. Tong, Man Tong, Feng Xu
Systematic testing of existing drugs and their combinations is an attractive strategy to exploit approved drugs for repurposing and identifying the best actionable treatment options. To expedite the search among many possible drug combinations, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d31650e8aba8ff18d553fdb90c91b01
https://doi.org/10.1158/0008-5472.c.6513603.v1
https://doi.org/10.1158/0008-5472.c.6513603.v1
Autor:
Alan S.L. Wong, Stephanie Ma, Gigi C.G. Choi, Koon Ho Wong, Yuanhua Huang, Lakhansing Pardeshi, Kylie Hin-Man Mak, Maggie S.H. Cheung, John H.C. Fong, Tin Lok Wong, Hoi Yee Chu, Becky K.C. Chan, Cindy S.W. Tong, Man Tong, Feng Xu
Supplementary Figures and Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54699c56716cef9dfd0eb48e956ea651
https://doi.org/10.1158/0008-5472.22430385
https://doi.org/10.1158/0008-5472.22430385
Autor:
William C.W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C.G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wroblewska, Manolis Kellis, Lin Zhang, Ron Weiss, Timothy K. Lu
Publikováno v:
Nature communications. 13(1)
Precise, scalable, and sustainable control of genetic and cellular activities in mammalian cells is key to developing precision therapeutics and smart biomanufacturing. We created a highly tunable, modular, versatile CRISPR-based synthetic transcript