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Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins.

Autor: Phillips CL; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Faridounnia M; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Battaglia RA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Evangelista BA; Department of Neurology, University of North Carolina at Chapel Hill., Cohen TJ; Department of Neurology, University of North Carolina at Chapel Hill., Opal P; Departments of Neurology and Cell and Developmental Biology, Northwestern University, Chicago, IL., Bouldin TW; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill., Armao D; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.; Department of Radiology, University of North Carolina at Chapel Hill., Snider NT; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.

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The CRL3 ^gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins.

Autor: Park HM; Biometrology Group, Korea Research Institute of Standards and Science, Daejeon 34113, Korea., Le L; Division of Quantum Simulation and Optimization, SandboxAQ, New York, NY 10591., Nguyen TT; Gehrke Proteomics Center, Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211., Nam KH; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Ordureau A; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Lee JE; Biometrology Group, Korea Research Institute of Standards and Science, Daejeon 34113, Korea., Nguyen TV; Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, MO 65212.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Nov 07; Vol. 120 (45), pp. e2306395120. Date of Electronic Publication: 2023 Oct 30.

Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival.

Autor: Allen, Elizabeth¹, Jianqing Ding¹, Wei Wang¹, Pramanik, Suneet¹, Chou, Jonathan¹, Yau, Vincent¹, Yanmin Yang¹ yyanmin@stanford.edu

Publikováno v: Nature. 11/10/2005, Vol. 438 Issue 7065, p224-228. 5p. 1 Color Photograph, 2 Graphs.