Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gift Pule"'
Autor:
Gift Pule, Ambroise Wonkam
Publikováno v:
The Pan African Medical Journal, Vol 18, Iss 46 (2014)
Sickle Cell Disease (SCD) is a multi-organ haemoglobinopathy with the greatest disease burden in sub-Saharan Africa. Hydroxyurea is the only available drug treatment for SCD, its major drawback being a reasonable proportion of non-responsive patient
Externí odkaz:
https://doaj.org/article/85557a1580da4304b34ab14d2e679a68
Additional file 1: Figure S1. Time dependent expression of markers of late erythroid differentiation (CD235a and CD71) in erythroid cells treated with HU. Expression of CD235a (A) and CD71 (B) during late erythroid differentiation show no significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a8170767578f3ad7ce7bd2d59ab26d
Autor:
Maddalena Martella, Mimma Campeggio, Gift Pulè, Ambroise Wonkam, Federica Menzato, Vania Munaretto, Giampietro Viola, Sabado P. Da Costa, Giulia Reggiani, Antonia Araujo, Dionisio Cumbà, Giuseppe Liotta, Laura Sainati, Fabio Riccardi, Raffaella Colombatti
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
BackgroundSickle Cell Disease (SCD) is an inherited condition that is widespread globally and especially in malaria-endemic West African countries. Limited epidemiological data on SCD are available for Guinea Bissau, where newborn screening is not ye
Externí odkaz:
https://doaj.org/article/6c2016b2b69e4b44921cfc28f8aa0581
Additional file 2: Figure S2. Time-dependant effect of hydroxyurea on cellular metabolic activity. To determine the optimal exposure time to HU (100 μM previously determined to be the optimal concentration), K562 cells (8 × 104 cells/100 μl) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b422b2af204219395cb6d1ba942d4c
Additional file 2: Figure S2. Time-dependant effect of hydroxyurea on cellular metabolic activity. To determine the optimal exposure time to HU (100 μM previously determined to be the optimal concentration), K562 cells (8 × 104 cells/100 μl) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::745abf8c9df49567450dac42a0245c3f
Additional file 3: Figure S3. Time-dependent effect of hydroxyurea on miRNAs expression in K562 cells. HU caused sigmoidal time-dependent changes in miRNAs expression in K562 cells with significant up-regulation of all miRNAs except miR-26b and miR49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e21e9c0e2ff6481c56c39d25ac21f22
Additional file 4: Figure S4. Time dependent luciferase activity in response to HU treatment of anti-miR-151-3p; anti-miR-451 and anti-miR-494 transfected K562 cells. Luciferase activity was highest after 6 and/or 12 h of HU treatment in for all anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55597cf5588ef28eebc447e7fb13d8d3
Additional file 5: Figure S5. Concentration-dependent inhibition of miR-26b; miR-151-3p; miR-451 and miR-494 down-regulates HbF protein in K562 cells. HbF protein was reduced at higher concentration of all anti-miRNAs. This suggests that most miRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76f36a6faede7123cd53da2f75d0827