Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gift D. Pule"'
Autor:
Khuthala Mnika, Gaston K. Mazandu, Mario Jonas, Gift D. Pule, Emile R. Chimusa, Neil A. Hanchard, Ambroise Wonkam
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Hydroxyurea (HU) is clinically beneficial in sickle cell disease (SCD) through fetal hemoglobin (HbF) induction; however, the mechanism of HU is not yet fully elucidated. Selected miRNAs have been associated with HU-induced HbF production. We have in
Externí odkaz:
https://doaj.org/article/f5661fb2d8f74c3b924a34b60cad6ba1
Autor:
Emile R. Chimusa, Nicola Mulder, Daniel Shriner, Gift D. Pule, Khuthala Mnika, Charles N. Rotimi, Adebowale Adeyemo, Ambroise Wonkam, Valentina Josiane Ngo Bitoungui
Publikováno v:
Clinical and Translational Medicine
Clinical and Translational Medicine, Vol 10, Iss 4, Pp n/a-n/a (2020)
Clinical and Translational Medicine, Vol 10, Iss 4, Pp n/a-n/a (2020)
Background Sickle cell anemia (SCA) is a clinically heterogeneous, monogenic disorder. Medical care has less‐than‐optimal impact on clinical outcomes in SCA in Africa due to several factors, including patient accessibility, poor access to resourc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030beac5b3dd6ab701b1b93193d3f76b
https://pubmed.ncbi.nlm.nih.gov/32898326
https://pubmed.ncbi.nlm.nih.gov/32898326
Autor:
Emile R. Chimusa, Gaston K. Mazandu, Gift D. Pule, Ambroise Wonkam, Khuthala Mnika, Neil A. Hanchard, Mario Jonas
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics, Vol 10 (2019)
Hydroxyurea (HU) is clinically beneficial in sickle cell disease (SCD) through fetal hemoglobin (HbF) induction; however, the mechanism of HU is not yet fully elucidated. Selected miRNAs have been associated with HU-induced HbF production. We have in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abdf80de73646cc8d8e585d159a8bdf
Autor:
Catherine Chunda-Liyoka, Melissa A. Haendel, Sumir Panji, Kwaku Ohene-Frempong, Marsha Treadwell, Kenneth Opap, Philomene Lopez-Sall, Simon Jupp, Kofi A. Anie, Bamidele O. Tayo, Vimal K. Derebail, Kais Ghedira, Karen Kengne Kamga, Solomon F. Ofori-Acquah, Andrew D. Campbell, Raphael Z. Sangeda, Adekunle Adekile, Furahini Chinenere, Muntaser E. Ibrahim, Neil A. Hanchard, Damian Nirenberg, Deogratias Munube, Carol Hamilton, Nicola Mulder, Mamana Mbiyavanga, Biobele J. Brown, Jennifer Knight-Madden, Léon Tshilolo, Victoria Nembaware, Baba Inusa, Charmaine D.M. Royal, Miriam Park, Obiageli E Nnodu, Wayne Huggins, Ambroise Wonkam, Gift D. Pule, Amy Geard
Publikováno v:
Applied and Translational Genomics, Vol 9, Iss C, Pp 23-29 (2016)
Applied & Translational Genomics
Applied & Translational Genomics, Elsevier, 2016, 9, pp.23-29. ⟨10.1016/j.atg.2016.03.005⟩
Applied & Translational Genomics
Applied & Translational Genomics, Elsevier, 2016, 9, pp.23-29. ⟨10.1016/j.atg.2016.03.005⟩
International audience; Sickle cell disease (SCD) is a debilitating single gene disorder caused by a single point mutation that results in physical deformation (i.e. sickling) of erythrocytes at reduced oxygen tensions. Up to 75% of SCD in newborns w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c43dd5c6fc8e6156d44e78040e7985c
http://www.sciencedirect.com/science/article/pii/S2212066116300187
http://www.sciencedirect.com/science/article/pii/S2212066116300187
Autor:
Stylianos E. Antonarakis, Gift D. Pule, Andre Pascal Kengne, Valentina Josiane Ngo Bitoungui, Bernard Chetcha Chemegni, Ambroise Wonkam
Publikováno v:
OMICS: A Journal of Integrative Biology, Vol. 19, No 10 (2015) pp. 627-631
Variants in BCL11A were previously associated with fetal hemoglobin (HbF) levels among Cameroonian sickle cell disease (SCD) patients, however explaining only ∼2% of the variance. In the same patients, we have investigated the relationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef5c62cd3c4bc6bf510e5dc8ef065bc
https://doi.org/10.1089/omi.2015.0124
https://doi.org/10.1089/omi.2015.0124
Autor:
Ambroise Wonkam, Neil A. Hanchard, Jeanne Ngogang, Gift D. Pule, Valentina Josiane Ngo Bitoungui
Publikováno v:
OMICS: A Journal of Integrative Biology. 19:171-179
Studies of hemoglobin S haplotypes in African subpopulations have potential implications for patient care and our understanding of genetic factors that have shaped the prevalence of sickle cell disease (SCD). We evaluated HBB gene cluster haplotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929ecd285688938b76978738a1e51d7f
https://doi.org/10.1089/omi.2014.0134
https://doi.org/10.1089/omi.2014.0134
Autor:
Ambroise Wonkam, Kudakwashe Mhandire, Gift D. Pule, Collet Dandara, Khuthala Mnika, Elizabeth Kampira, Emile R. Chimusa
Publikováno v:
Global Health, Epidemiology and Genomics
Partial carrier-resistance toPlasmodium falciparummalaria conferred by the sickle cell (HbS) mutation has resulted in the local amplification and positive selection of sickle cell disease (SCD) in malaria-endemic regions and particularly in sub-Sahar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69be33a35dd8c07e3ce017a72f28eb6b
http://europepmc.org/articles/PMC5870409
http://europepmc.org/articles/PMC5870409
Autor:
Bernard Chetcha Chemegni, Andre Pascal Kengne, Valentina Josiane Ngo Bitoungui, Ambroise Wonkam, Gift D. Pule
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 10, Iss 1, Pp 1-5 (2017)
BMC Research Notes, Vol 10, Iss 1, Pp 1-5 (2017)
Background Reactivation of adult hemoglobin (HbF) is currently a dominant therapeutic approach to sickle cell disease (SCD). In this study, we have investigated among SCD patients from Cameroon, the association of HbF level and variants in the HU-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e45d7d7f88e8f37bc0753ea03d39f45
http://europepmc.org/articles/PMC5427596
http://europepmc.org/articles/PMC5427596
Publikováno v:
South African Medical Journal; Vol 107, No 2 (2017); 149-155
South African Medical Journal, Vol 107, Iss 2, Pp 149-155 (2017)
SAMJ: South African Medical Journal, Volume: 107, Issue: 2, Pages: 149-155, Published: FEB 2017
South African Medical Journal, Vol 107, Iss 2, Pp 149-155 (2017)
SAMJ: South African Medical Journal, Volume: 107, Issue: 2, Pages: 149-155, Published: FEB 2017
Background. An exponential increase in the number of sickle cell disease (SCD) patients in paediatric services in Cape Town, South Africa, has been reported. The trend in adult/adolescent services has not been investigated. Objectives. To evaluate ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19f2756779e025ced6b900499b3e4a6
https://www.ajol.info/index.php/samj/article/view/151734
https://www.ajol.info/index.php/samj/article/view/151734
Autor:
Bernard Chetcha Chemegni, Amy Geard, Gift D. Pule, Valentina Josiane Ngo Bitoungui, Emile R. Chimusa, Ambroise Wonkam, Andre Pascal Kengne
Publikováno v:
British journal of haematology. 178(4)
Micro-albuminuria and glomerular hyperfiltration are primary indicators of renal dysfunctions in Sickle Cell Disease (SCD), with more severe manifestations previously associated with variants in APOL1 and HMOX1 among African Americans. We have invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59ac0a77b160220be16f94953a7fafc
https://pubmed.ncbi.nlm.nih.gov/28466968
https://pubmed.ncbi.nlm.nih.gov/28466968