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Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

Autor: Huber Peter E, Debus Jürgen, Ansorge Wilhelm, Giese Nathalia A, Wirkner Ute, Jiang Xiaohua, Samkharadze Tamar, Schwager Christian, Pan Zheng, Weis Nadine, Erkan Mert, Friess Helmut, Abdollahi Amir, Kleeff Jörg

Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 88 (2010)

Abstract Background Tissue fibrosis is an integral component of chronic inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenesis. To identify organ

Externí odkaz: https://doaj.org/article/c804baaf41a640198f4c65fa4dc0b129

Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis

Autor: Weigand Markus, Giese Thomas, Bergmann Frank, Deucker Stefanie, Reiser Carolin, Erkan Mert, Gorbachevski Andre, Michalski Christoph W, Giese Nathalia A, Friess Helmut, Kleeff Jörg

Publikováno v: Journal of Translational Medicine, Vol 5, Iss 1, p 63 (2007)

Abstract Background Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP). Methods Markers of fibrosis and inflammation

Externí odkaz: https://doaj.org/article/c8ebacf0c0e74654b8645c49d4ce65bb

Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer

Autor: Giese Nathalia A, Kayed Hany, Abiatari Ivane, Kleeff Jörg, Li Junsheng, Felix Klaus, Giese Thomas, Büchler Markus W, Friess Helmut

Publikováno v: Molecular Cancer, Vol 4, Iss 1, p 14 (2005)

Abstract Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor signaling. Since pancreatic canc

Externí odkaz: https://doaj.org/article/d1b75ea8d1cf47b89f559fd761bd4b54

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

Autor: Campa, Daniele, Gentiluomo, Manuel, Stein, Angelika, Aoki, Mateus Nóbrega, Oliverius, Martin, Vodičková, Ludmila, Jamroziak, Krzysztof, Theodoropoulos, George, Pasquali, Claudio, Greenhalf, William, Arcidiacono, Paolo Giorgio, Uzunoglu, Faik, Pezzilli, Raffaele, Luchini, Claudio, Puzzono, Marta, Loos, Martin, Giaccherini, Matteo, Katzke, Verena, Mambrini, Andrea, Kiudeliene, Edita, Federico, Kauffmann Emanuele, Johansen, Julia, Hussein, Tamás, Mohelnikova-Duchonova, Beatrice, van Eijck, Casper H.J., Brenner, Hermann, Farinella, Riccardo, Pérez, Juan Sainz, Lovecek, Martin, Büchler, Markus W., Hlavac, Viktor, Izbicki, Jakob R., Hackert, Thilo, Chammas, Roger, Zerbi, Alessandro, Lawlor, Rita, Felici, Alessio, Götz, Mara, Capurso, Gabriele, Ginocchi, Laura, Gazouli, Maria, Kupcinskas, Juozas, Cavestro, Giulia Martina, Vodicka, Pavel, Moz, Stefania, Neoptolemos, John P., Kunovsky, Lumir, Bojesen, Stig E., Carrara, Silvia, Gioffreda, Domenica, Morkunas, Egidijus, Abian, Olga, Bunduc, Stefania, Basso, Daniela, Boggi, Ugo, Wlodarczyk, Barbara, Szentesi, Andrea, Vanella, Giuseppe, Chen, Inna, Bijlsma, Maarten F., Kiudelis, Vytautas, Landi, Stefano, Schöttker, Ben, Corradi, Chiara, Giese, Nathalia, Kaaks, Rudolf, Peduzzi, Giulia, Hegyi, Péter, Morelli, Luca, Furbetta, Niccolò, Soucek, Pavel, Latiano, Anna, Talar-Wojnarowska, Renata, Lindgaard, Sidsel C., Dijk, Frederike, Milanetto, Anna Caterina, Tavano, Francesca, Cervena, Klara, Erőss, Bálint, Testoni, Sabrina G., Verhagen-Oldenampsen, Judith H.E., Małecka-Wojciesko, Ewa, Costello, Eithne, Salvia, Roberto, Maiello, Evaristo, Ermini, Stefano, Sperti, Cosimo, Holleczek, Bernd, Perri, Francesco, Skieceviciene, Jurgita, Archibugi, Livia, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico

Publikováno v: In Critical Reviews in Oncology / Hematology June 2023 186