Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Giel Hendriks"'
Autor:
Andrea Cediel-Ulloa, Christina Isaxon, Axel Eriksson, Daniel Primetzhofer, Mauricio A. Sortica, Lars Haag, Remco Derr, Giel Hendriks, Jakob Löndahl, Anders Gudmundsson, Karin Broberg, Anda R. Gliga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Welding fumes induce lung toxicity and are carcinogenic to humans but the molecular mechanisms have yet to be clarified. The aim of this study was to evaluate the toxicity of stainless and mild steel particles generated via gas–metal arc w
Externí odkaz:
https://doaj.org/article/5d22e92021034835aad43265aed02e6e
Autor:
Sarah McCarrick, Francesca Cappellini, Amanda Kessler, Nynke Moelijker, Remco Derr, Jonas Hedberg, Susanna Wold, Eva Blomberg, Inger Odnevall Wallinder, Giel Hendriks, Hanna L. Karlsson
Publikováno v:
Nanomaterials, Vol 10, Iss 1, p 110 (2020)
The increased use of nanoparticles (NPs) requires efficient testing of their potential toxic effects. A promising approach is to use reporter cell lines to quickly assess the activation of cellular stress response pathways. This study aimed to use th
Externí odkaz:
https://doaj.org/article/1c0ff74a96704fc2ad53c5fe2911c5e5
Autor:
Yax Thakkar, Holger Moustakas, Nynke Moelijker, Giel Hendriks, Inger Brandsma, Stefan Pfuhler, Anne Marie Api
Publikováno v:
Environmental and Molecular Mutagenesis. 64:234-243
Publikováno v:
Environmental and Molecular Mutagenesis. 64:132-143
Autor:
Amer Jamalpoor, Sabine Hartvelt, Myrto Dimopoulou, Tom Zwetsloot, Inger Brandsma, Peter I. Racz, Torben Osterlund, Giel Hendriks
Publikováno v:
Birth Defects Research. 114:1210-1228
Testing for developmental toxicity according to the current regulatory guidelines requires large numbers of animals, making these tests very resource intensive, time-consuming, and ethically debatable. Over the past decades, several alternative in vi
Autor:
Marit E Geijer, Nynke Moelijker, Gaonan Zhang, Remco Derr, Torben Osterlund, Giel Hendriks, Inger Brandsma
Publikováno v:
Toxicological Sciences. 186:288-297
Aneuploidy is characterized by the presence of an abnormal number of chromosomes and is a common hallmark of cancer. However, exposure to aneugenic compounds does not necessarily lead to cancer. Aneugenic compounds are mainly identified using the in
Autor:
Marc A. Beal, Marc Audebert, Tara Barton‐Maclaren, Hannah Battaion, Jeffrey C. Bemis, Xuefei Cao, Connie Chen, Stephen D. Dertinger, Roland Froetschl, Xiaoqing Guo, George Johnson, Giel Hendriks, Laure Khoury, Alexandra S. Long, Stefan Pfuhler, Raja S. Settivari, Shamika Wickramasuriya, Paul White
Publikováno v:
Environmental and molecular mutagenesis, Early View
Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, aneugenicity) have been limited to dichotomous hazard classification, while other tox
Publikováno v:
Journal of toxicology and environmental health. Part A. 85(19)
It has been reported that incorporation of fire retardants into home furnishings and electronics increases the toxicity of smoke produced during combustion in house fires. Studies have been limited to exercises in analytical chemistry but the biologi
Autor:
Giel Hendriks, Roman Wieczorek, Jutta Pani, Liam Simms, Edgar Trelles Sticken, Lukasz Czekala, Remco Derr, Kathryn Rudd, Lisa Maria Bode, Fiona Chapman, Nynke Moelijker, Inger Brandsma, Tanvir Walele, Matthew Stevenson
Publikováno v:
Mutagenesis
In vitro (geno)toxicity assessment of electronic vapour products (EVPs), relative to conventional cigarette, currently uses assays, including the micronucleus and Ames tests. Whilst informative on induction of a finite endpoint and relative risk pose
Publikováno v:
Toxicology letters. 362
Nucleoside analogues have long been designed and tested in cancer treatment and against viral infections. However, several early compounds were shown to have mutagenic properties as a consequence of their mode-of-action. This limited their use, and s