Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Giel G, van Dooren"'
Autor:
Merryn Fraser, Blake Curtis, Patrick Phillips, Patrick A Yates, Kwong Sum Lam, Otto Netzel, Giel G van Dooren, Alyssa Ingmundson, Kai Matuschewski, Malcolm D McLeod, Alexander G Maier
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1515-1532 (2024)
Abstract Parasites, such as the malaria parasite P. falciparum, are critically dependent on host nutrients. Interference with nutrient uptake can lead to parasite death and, therefore, serve as a successful treatment strategy. P. falciparum parasites
Externí odkaz:
https://doaj.org/article/ff09ddd81108437faeee65fa9548788b
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Succinate dehydrogenase (SDH) is a protein complex that functions in the tricarboxylic acid cycle and the electron transport chain of mitochondria. In most eukaryotes, SDH is highly conserved and comprises the following four subunits: SdhA and SdhB f
Externí odkaz:
https://doaj.org/article/fe2f195b52354694a753053acf42f1c4
Autor:
Vanessa M. Howieson, Joy Zeng, Joachim Kloehn, Christina Spry, Chiara Marchetti, Matteo Lunghi, Emmanuel Varesio, Andrew Soper, Anthony G. Coyne, Chris Abell, Giel G. van Dooren, Kevin J. Saliba
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 1-8 (2023)
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug tar
Externí odkaz:
https://doaj.org/article/00b024bbf99f4341a185721a0ef4505e
Autor:
Jenni A Hayward, F Victor Makota, Daniela Cihalova, Rachel A Leonard, Esther Rajendran, Soraya M Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J Saliba, Alexander G Maier, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011987 (2024)
[This corrects the article DOI: 10.1371/journal.ppat.1011517.].
Externí odkaz:
https://doaj.org/article/c192140a1d294373bec4e82a93a0eb00
Autor:
Jenni A Hayward, F Victor Makota, Daniela Cihalova, Rachel A Leonard, Esther Rajendran, Soraya M Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J Saliba, Alexander G Maier, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011517 (2023)
Apicomplexans are widespread parasites of humans and other animals, and include the causative agents of malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii). Existing anti-apicomplexan therapies are beset with issues around drug resista
Externí odkaz:
https://doaj.org/article/3a72707fe5c84a1cbf9650cd91318ee5
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D. Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K. Tripathi, Nina F. Gnadig, Tomas Yeo, Kate J. Fairhurst, Barbara H. Stokes, James M. Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Esther K. Schmitt, Judith Straimer, Anthony T. Papenfuss, Marcus C. S. Lee, Ben Corry, Photini Sinnis, David A. Fidock, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the f
Externí odkaz:
https://doaj.org/article/7abacde286514d8b929ffa3fbc4d3a0f
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011430 (2023)
The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs considerably from the ETC of the animals that these parasites infect, and is the target of numerous anti-parasitic drugs. The cytochrome c oxidase complex (Complex IV)
Externí odkaz:
https://doaj.org/article/bcdb96c19edd4c67b947c5845d8e4ce6
Autor:
Joy M. Zeng, Sanduni V. Hapuarachchi, Sarah H. Shafik, Rowena E. Martin, Kiaran Kirk, Giel G. van Dooren, Adele M. Lehane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites
Externí odkaz:
https://doaj.org/article/2487d4ef217541f185f3c2fd767c2794
Autor:
Stephen J Fairweather, Esther Rajendran, Martin Blume, Kiran Javed, Birte Steinhöfel, Malcolm J McConville, Kiaran Kirk, Stefan Bröer, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009835 (2021)
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large family of apicomplexan-specific plasma membrane-localized amino acid transporters, the ApiAT
Externí odkaz:
https://doaj.org/article/53e61d32b3994dd4b73f4ec8560f0c98
Autor:
Esther Rajendran, Morgan Clark, Cibelly Goulart, Birte Steinhöfel, Erick T Tjhin, Simon Gross, Nicholas C Smith, Kiaran Kirk, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009816 (2021)
Intracellular parasites, such as the apicomplexan Toxoplasma gondii, are adept at scavenging nutrients from their host. However, there is little understanding of how parasites sense and respond to the changing nutrient environments they encounter dur
Externí odkaz:
https://doaj.org/article/e6aa59b199ac4fd4be72d45596137ba1