Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Giedrius Kalesnykas"'
Autor:
Inesa Lelyte, Vidhya R. Rao, Giedrius Kalesnykas, Symantas Ragauskas, Simon Kaja, Zubair Ahmed
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Diabetic retinopathy (DR) is a multifactorial disease displaying vascular-associated pathologies, including vascular leakage and neovascularization, ultimately leading to visual impairment. However, animal models accurately reflecting these
Externí odkaz:
https://doaj.org/article/95bca3c8ce294d8c8cbb15c797015760
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308671 (2024)
Glaucoma is a multifactorial optic neuropathy that primarily affecting retinal ganglion cells (RGC). Brimonidine is an intraocular pressure-lowering drug with reported neuroprotective properties. This study aimed to compare the neuroprotective effect
Externí odkaz:
https://doaj.org/article/55777ab05ab14767b05143ac1de80d99
Autor:
Deepakkumar Mishra, Hákon Hrafn Sigurðsson, Ana Paula Serro, Giedrius Kalesnykas, Ryan F Donnelly, Raghu Raj Singh Thakur
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Choroidal neovascularization (CNV) is one of the hallmark symptoms of Wet Age-related Macular Degeneration (wAMD) and DiabeticRetinopathy(DR) which involves formation of neoangiogenic i.e. formation of new abnormal blood vessels emerging from the cho
Externí odkaz:
https://doaj.org/article/648f173272c94f22bf42022a5785ba43
Autor:
Anita Kirti Ghosh, Rubina Thapa, Harsh Nilesh Hariani, Michael Volyanyuk, Sean David Ogle, Karoline Anne Orloff, Samatha Ankireddy, Karen Lai, Agnė Žiniauskaitė, Evan Benjamin Stubbs, Giedrius Kalesnykas, Jenni Johanna Hakkarainen, Kelly Ann Langert, Simon Kaja
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1362 (2021)
Oxidative stress is a known contributor to the progression of dry eye disease pathophysiology, and previous studies have shown that antioxidant intervention is a promising therapeutic approach to reduce the disease burden and slow disease progression
Externí odkaz:
https://doaj.org/article/0b6e150beb0c47a1810741e8cb7c3e7e
Autor:
Agnė Žiniauskaitė, Vytautas Cėpla, Tadas Jelinskas, Romuald Eimont, Artūras Ulčinas, Rūta Aldonytė, Ramūnas Valiokas, Giedrius Kalesnykas, Jenni J. Hakkarainen
Publikováno v:
Sci, Vol 3, Iss 3, p 30 (2021)
There is a growing need for novel in vitro corneal models to replace animal-based ex vivo tests in drug permeability studies. In this study, we demonstrated a corneal mimetic that models the stromal and epithelial compartments of the human cornea. Hu
Externí odkaz:
https://doaj.org/article/33de8134a50e463f9a89b36985e28610
Autor:
Henri Leinonen, Velta Keksa-Goldsteine, Symantas Ragauskas, Philip Kohlmann, Yajuvinder Singh, Ekaterina Savchenko, Jooseppi Puranen, Tarja Malm, Giedrius Kalesnykas, Jari Koistinaho, Heikki Tanila, Katja M. Kanninen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The Finnish variant of late infantile neuronal ceroid lipofuscinosis (CLN5 disease) belongs to a family of neuronal ceroid lipofuscinosis (NCLs) diseases. Vision loss is among the first clinical signs in childhood forms of NCLs. Mutations in
Externí odkaz:
https://doaj.org/article/bb6f6dcb4fdd4a55869968c7e9693326
Autor:
Symantas Ragauskas, Henri Leinonen, Jooseppi Puranen, Seppo Rönkkö, Soile Nymark, Kestutis Gurevicius, Arto Lipponen, Outi Kontkanen, Jukka Puoliväli, Heikki Tanila, Giedrius Kalesnykas
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113317 (2014)
Huntington's disease (HD) is an inherited neurodegenerative disorder that primarily affects the medium-size GABAergic neurons of striatum. The R6/2 mouse line is one of the most widely used animal models of HD. Previously the hallmarks of HD-related
Externí odkaz:
https://doaj.org/article/8f5a4c0ad30c4f1583d229f60ec6e934
Autor:
Karl J Wahlin, Raymond A Enke, John A Fuller, Giedrius Kalesnykas, Donald J Zack, Shannath L Merbs
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79140 (2013)
Vertebrate genomes undergo epigenetic reprogramming during development and disease. Emerging evidence suggests that DNA methylation plays a key role in cell fate determination in the retina. Despite extensive studies of the programmed cell death that
Externí odkaz:
https://doaj.org/article/c078ea380d6848b08d710637bd829532
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 38:271-286
The streptozotocin (STZ)-induced rodent model is one of the most commonly employed models in preclinical drug discovery for diabetic retinopathy (DR). However, standardization and validation of experimental readouts are largely lacking. The aim of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d216649158a9904b6fd3ebd6555955c7
https://doi.org/10.1089/jop.2021.0128
https://doi.org/10.1089/jop.2021.0128
Autor:
Marco Brugnera, Flavia Messina, Alison Reynolds, Niall O'Reilly, Giedrius Kalesnykas, Rocío Herrero‐Vanrell, Breandán Kennedy, Irene Bravo‐Osuna
Publikováno v:
Acta Ophthalmologica. 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d3e770e6457cb68125562cb50bd437
https://doi.org/10.1111/j.1755-3768.2022.0369
https://doi.org/10.1111/j.1755-3768.2022.0369