Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Gideon M, Hirschfield"'
Autor:
Gideon M. Hirschfield, Katherine Arndtz, Amanda Kirkham, Yung-Yi Chen, Richard Fox, Anna Rowe, Jessica Douglas-Pugh, Douglas Thorburn, Eleanor Barnes, Guruprasad P. Aithal, Diana Hull, Khushpreet Bhandal, Kathryn Olsen, Paul Woodward, Siân Lax, Philip Newsome, David J. Smith, Antero Kallio, David H. Adams, Victoria Homer, Chris J. Weston
Publikováno v:
Hepatology Communications, Vol 8, Iss 5 (2024)
Background:. Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We evaluated the
Externí odkaz:
https://doaj.org/article/1b222fe6ac3c4e409c92ca04f98f474a
Autor:
Suz Warner, Jeremy Rajanayagam, Emily Russell, Carla Lloyd, James Ferguson, Deirdre A. Kelly, Gideon M. Hirschfield
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100901- (2024)
Background & Aims: Long-term follow-up studies of paediatric onset autoimmune liver disease (AILD) are invaluable in helping better understand the clinical course of disease. In day-to-day practice clinicians struggle with disease definitions whilst
Externí odkaz:
https://doaj.org/article/f5bfef1276b7434e8fbd422df4becb20
Autor:
Fernanda Onofrio, Katina Zheng, Cherry Xu, Shiyi Chen, Wei Xu, Mary Vyas, Katie Bingham, Keyur Patel, Leslie Lilly, Mark Cattral, Nazia Selzner, Elmar Jaeckel, Cynthia Tsien, Aliya Gulamhusein, Gideon M. Hirschfield, Mamatha Bhat
Publikováno v:
Hepatology Communications, Vol 7, Iss 8 (2023)
Background:. Liver transplantation (LT) is frequently lifesaving for people living with primary sclerosing cholangitis (PSC). However, patients are waitlisted for LT according to the model for end-stage liver disease-sodium (MELD-Na) score, which may
Externí odkaz:
https://doaj.org/article/2b11aa1f87db488d9f804a95cd17c0e3
Autor:
Christoph Schramm, Heiner Wedemeyer, Andrew Mason, Gideon M. Hirschfield, Cynthia Levy, Kris V. Kowdley, Piotr Milkiewicz, Ewa Janczewska, Elena Sergeevna Malova, Johanne Sanni, Phillip Koo, Jin Chen, Subhajit Choudhury, Lloyd B. Klickstein, Michael K. Badman, David Jones
Publikováno v:
JHEP Reports, Vol 4, Iss 11, Pp 100544- (2022)
Background & Aims: The safety, tolerability, and efficacy of the non-bile acid farnesoid X receptor agonist tropifexor were evaluated in a phase II, double-blind, placebo-controlled study as potential second-line therapy for patients with primary bil
Externí odkaz:
https://doaj.org/article/3923e32517ec458db31731c6b79c2204
Multiparametric Magnetic Resonance Imaging, Autoimmune Hepatitis, and Prediction of Disease Activity
Autor:
Katherine Arndtz, Elizabeth Shumbayawonda, James Hodson, Peter J. Eddowes, Andrea Dennis, Helena Thomaides‐Brears, Sofia Mouchti, Matt D. Kelly, Rajarshi Banerjee, Stefan Neubauer, Gideon M. Hirschfield
Publikováno v:
Hepatology Communications, Vol 5, Iss 6, Pp 1009-1020 (2021)
Noninvasive monitoring of disease activity in autoimmune hepatitis (AIH) has potential advantages for patients for whom liver biopsy is invasive and with risk. We sought to understand the association of multiparametric magnetic resonance imaging (mpM
Externí odkaz:
https://doaj.org/article/bf14b411ad5b45c4a93ad036a8e94026
Autor:
Surain B. Roberts, Marwa Ismail, Gowthami Kanagalingam, Andrew L. Mason, Mark G. Swain, Catherine Vincent, Eric M. Yoshida, Cynthia Tsien, Jennifer A. Flemming, Harry L.A. Janssen, Gideon M. Hirschfield, Bettina E. Hansen, Aliya F. Gulamhusein, the Canadian Network for Autoimmune Liver Disease
Publikováno v:
Hepatology Communications, Vol 4, Iss 9, Pp 1332-1345 (2020)
Patients with primary biliary cholangitis (PBC) with incomplete response to ursodeoxycholic acid are at risk of disease progression and need additional therapy. Obeticholic acid (OCA) was approved in Canada in May 2017, but its effectiveness in a rea
Externí odkaz:
https://doaj.org/article/0b61f127e4ca4dbfb8963ff2a0226bb9
Autor:
Piotr Milkiewicz, Marcin Krawczyk, Ewa Wunsch, Cyriel Ponsioen, Gideon M. Hirschfield, Stefan G. Hubscher
Publikováno v:
Hepatology Communications, Vol 4, Iss 3, Pp 399-408 (2020)
Patients with primary sclerosing cholangitis (PSC) frequently manifest features of autoimmune hepatitis (AIH). We sought to understand factors affecting expert management, with the goal of facilitating uniformity of care. A Survey Monkey questionnair
Externí odkaz:
https://doaj.org/article/146c26a03f7a41ac82103caed99d0e11
Autor:
Nwe Ni Than, James Hodson, Daniel Schmidt-Martin, Richard Taubert, Rebecca E. Wawman, Meemee Botter, Nishant Gautam, Kilian Bock, Rebecca Jones, Gautham D Appanna, Andrew Godkin, Aldo J. Montano-Loza, Frank Lammert, Christoph Schramm, Michael P. Manns, Mark Swain, Kelly W. Burak, David H. Adams, Gideon M Hirschfield, Ye Htun Oo
Publikováno v:
JHEP Reports, Vol 1, Iss 6, Pp 437-445 (2019)
Background & Aims: Treatment options remain limited for patients with autoimmune hepatitis (AIH), while there are still concerns over the consequences of long-term corticosteroid use. A few studies have suggested a role for B cell-driven autoimmune l
Externí odkaz:
https://doaj.org/article/bcb9f7c48c3a4df4a706283363e04ef1
Autor:
Yung-Yi Chen, Kathryn Arndtz, Gwilym Webb, Margaret Corrigan, Sarah Akiror, Evaggelia Liaskou, Paul Woodward, David H. Adams, Chris J. Weston, Gideon M. Hirschfield
Publikováno v:
JHEP Reports, Vol 1, Iss 5, Pp 369-376 (2019)
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive inflammatory and fibrotic injury to the biliary tree. We sought to further delineate the contribution of macrophage lineages i
Externí odkaz:
https://doaj.org/article/f2463d17726849958175a35e455840f2
Autor:
Ye Htun Oo, Susan Ackrill, Richard Cole, Lee Jenkins, Philip Anderson, Hannah C. Jeffery, Nicholas Jones, Louisa E. Jeffery, Philipp Lutz, Rebecca E. Wawman, Amrita Kaur Athwal, Jacqui Thompson, Joanna Gray, Kathy Guo, Darren Barton, Gideon M Hirschfield, Timothy Wong, Peter Guest, David H. Adams
Publikováno v:
JHEP Reports, Vol 1, Iss 4, Pp 286-296 (2019)
Background & Aims: Autoimmune hepatitis (AIH) is an immune-mediated disease with no curative treatment. Regulatory T cell (Treg) therapy is potentially curative in AIH given the critical role of Tregs in preventing autoimmunity. To work effectively,
Externí odkaz:
https://doaj.org/article/af638d03a9eb48ab9834adc56583e9a6