Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gideon Coster"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
DNA replication of repetitive sequences was recreated in a test tube using purified components. DNA alone was sufficient to induce stalling. Both stalling and recovery were dictated by the capacity of DNA to fold into unusual secondary structures.
Externí odkaz:
https://doaj.org/article/5dff189daf7c41acb81b8f6f83fd3732
Autor:
Sophie L. Williams, Corella S. Casas-Delucchi, Federica Raguseo, Dilek Guneri, Yunxuan Li, Masashi Minamino, Emma Elisabeth Fletcher, Joseph T. P. Yeeles, Ulrich F. Keyser, Zoë A. E. Waller, Marco Di Antonio, Gideon Coster
Sequences that can form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play a range of physiological roles. However, they can also pose a challenge to the replication machine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73cad152671fb4a67e2f71454ac05f6d
https://doi.org/10.1101/2022.11.18.517070
https://doi.org/10.1101/2022.11.18.517070
Autor:
Corella S. Casas-Delucchi, Christoph Engel, Patrick Weber, Julia L. Daiß, M. Cristina Cardoso, Gideon Coster, Peng Zhang, Cathia Rausch, Florian D. Hastert
Publikováno v:
Nucleic Acids Research
DNA base modifications diversify the genome and are essential players in development. Yet, their influence on DNA physical properties and the ensuing effects on genome metabolism are poorly understood. Here, we focus on the interplay of cytosine modi
SUMMARYAccurate chromosomal DNA replication is essential to maintain genomic stability. Genetic evidence suggests that certain repetitive sequences impair replication, yet the underlying mechanism is poorly defined. Replication could be directly inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfde27bacb3fcd3d3364dbabd55d9b0d
https://doi.org/10.1101/2021.06.02.446729
https://doi.org/10.1101/2021.06.02.446729
Autor:
Gideon Coster, John F.X. Diffley
Publikováno v:
Science
Getting loaded—make mine a double! Chromosomal DNA replication initiates bidirectionally by loading two ring-shaped helicases onto DNA in opposite orientations. How this symmetry is achieved has been puzzling because replication initiation sites co
Publikováno v:
Molecular Cell
Summary Loading of the six related Minichromosome Maintenance (MCM) proteins as head-to-head double hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DNA replication in eukaryotic cells. Assembly of these pr
Publikováno v:
Journal of Biological Chemistry. 287:36488-36498
The first step in V(D)J recombination is the formation of specific DNA double-strand breaks (DSBs) by the RAG1 and RAG2 proteins, which form the RAG recombinase. DSBs activate a complex network of proteins termed the DNA damage response (DDR). A key
Autor:
Gideon Coster, Michal Goldberg
Publikováno v:
Nucleus. 1:166-178
The DNA damage response (DDR) is comprised of a network of proteins that respond to DNA damage. Mediator of DNA Damage Checkpoint 1 (MDC1) plays an early and important role in the DDR. Recent data show that MDC1 binds multiple proteins that participa