Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Gideon A. Rodan"'
Basic principles - cell biology biochemistry bone re-modelling and mineral homeostasis the hormones of bone other systemic hormones that influence bone metabolism local regulators of bone molecular mechanisms of metabolic bone diseases pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e246d847c36e8ba929b5abda9f8ad5bf
https://doi.org/10.1016/c2015-1-01622-2
https://doi.org/10.1016/c2015-1-01622-2
Autor:
W. Cameron Black, Jean-François Lévesque, Denis Riendeau, Jean-Pierre Falgueyret, Kevin P. Bateman, M. David Percival, Elise Isabel, Tammy LeRiche, Vouy Linh Truong, Jacques Yves Gauthier, Michel Therien, Robert Zamboni, Sevgi B. Rodan, Sylvie Desmarais, Christophe Mellon, Deborah A. Nicoll-Griffith, Renata Oballa, Gregg Wesolowski, Sonia Lamontagne, Carmai Seto, Nathalie Chauret, Chun Sing Li, Robert N. Young, Frédéric Massé, Wanda Cromlish, Daniel J. McKay, Le T. Duong, Cheuk K. Lau, Serge Leger, Joel Robichaud, Gideon A. Rodan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:887-892
MK-0674 is a potent and selective cathepsin K inhibitor from the same structural class as odanacatib with a comparable inhibitory potency profile against Cat K. It is orally bioavailable and exhibits long half-life in pre-clinical species. In vivo st
Autor:
J.G. Seedor, M. Shea, Wilson C. Hayes, A. Markatos, D.B. Lauritzen, Elizabeth R. Myers, Gideon A. Rodan, Brian C. Toolan, H.M. Le, R. Balena
Publikováno v:
Journal of Bone and Mineral Research. 8:871-879
Prostaglandin E2 (PGE2) has been shown to stimulate both bone resorption and formation in experimental animals, leading to augmentation of trabecular and cortical bone. The amino bisphosphonate alendronate (ALN) is a potent inhibitor of bone resorpti
Publikováno v:
Journal of Bone and Mineral Research. 1:441-455
1,25-dihydroxyvitamin D3 produces pronounced shape changes in fetal rat calvaria and osteosarcoma-derived (ROS 17/2.8) osteoblastic cells, characterized by retracting processes and cell rounding followed by aggregation of cells. The 1,25(OH)2D3 effec
Publikováno v:
Journal of Bone and Mineral Research. 8:403-414
Recent findings suggest that the vitronectin receptor, a member of the integrin family, plays an important role in the attachment of osteoclasts to bone matrix. We report here the localization by in situ hybridization of the mRNA for the alpha and be
Autor:
Gideon A. Rodan, Larry J. Suva, Naoto Endo, David D. Thompson, Itai Bab, Helen A. Quartuccio, Gregory J. Seedor
Publikováno v:
Journal of Bone and Mineral Research. 8:379-388
Following injury to bone marrow there is a phase of osteogenesis in which bone trabeculae replace the initial blood clot and fill the marrow cavity. The newly formed bone is subsequently fully resorbed by osteoclasts and normal bone marrow is restore
Autor:
Gideon A. Rodan
Publikováno v:
Journal of Bone and Mineral Research. 6:527-530
Publikováno v:
Journal of Bone and Mineral Research. 1:213-220
This study compares the metabolism of [14C]-arachidonic acid between PGE2 synthesizing (ROS 17/2.8) and nonsynthesizing (ROS 25/1) osteosarcoma cell lines. In both cell lines: (a) 90% of [14C]-arachidonic acid was taken up at 24 h. (b) More than 90%
Autor:
Klaus Klaushofer, Marie-Helene Lafage, Peter Fratzl, Paul Roschger, Sabine Schreiber, Gideon A. Rodan
Publikováno v:
ResearcherID
Scopus-Elsevier
Scopus-Elsevier
Sodium fluoride (NaF), which stimulates bone formation, and bisphosphonates, which reduce bone resorption, are both used in the treatment of osteoporosis, and are binding to bone mineral. In this study, using small-angle X-ray scattering and backscat
Publikováno v:
Journal of Bone and Mineral Research. 6:725-731
Recently we characterized the immobilization-related osteopenia in adult rats and showed that it is caused by increased bone resorption and decreased bone formation (Weinreb et al. 1989 Bone 10:187). To assess the effect of age on disuse osteopenia,