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Systemic inflammation and metabolic disturbances underlie inpatient mortality among ill children with severe malnutrition.

Autor: Bijun Wen^1,2, Njunge, James M.^3,4, Bourdon, Celine^2,3, Gonzales, Gerard Bryan⁵, Gichuki, Bonface M.^3,4, Lee, Dorothy², Wishart, David S.⁶, Ngari, Moses^3,4, Chimwezi, Emmanuel³, Thitiri, Johnstone^3,4, Mwalekwa, Laura^4,7, Voskuijl, Wieger^3,8,9, Berkley, James A.^3,4,10, Bandsma, Robert H. J.^1,2,3,9,11 robert.bandsma@sickkids.ca

Publikováno v: Science Advances. 2/18/2022, Vol. 8 Issue 7, p1-14. 14p.

The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia.

Autor: Njunge JM; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Tickell K; Global Health and Epidemiology, University of Washington, Seattle, Seattle, USA., Diallo AH; Department of Public Health, Faculty of Health Sciences, University of Ouagadougou, Ouagadougou, Burkina Faso., Sayeem Bin Shahid ASM; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Gazi MA; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Saleem A; Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Karachi, Pakistan., Kazi Z; Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Karachi, Pakistan., Ali S; Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Karachi, Pakistan., Tigoi C; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mupere E; Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda., Lancioni CL; Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA., Yoshioka E; Global Health and Epidemiology, University of Washington, Seattle, Seattle, USA., Chisti MJ; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Mburu M; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Ngari M; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Ngao N; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Gichuki B; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Omer E; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Gumbi W; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Singa B; Kenya Medical Research Institute, Nairobi, Kenya., Bandsma R; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biomedical Sciences, University of Malawi College of Medicine, Blantyre, Malawi., Ahmed T; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Voskuijl W; Amsterdam UMC location, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Centre for Global Child Health & Emma Children's Hospital, Amsterdam, The Netherlands., Williams TN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College London, London, UK., Macharia A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Makale J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mitchel A; SomaLogic, Boulder, Colorado, USA., Williams J; SomaLogic, Boulder, Colorado, USA., Gogain J; SomaLogic, Boulder, Colorado, USA., Janjic N; SomaLogic, Boulder, Colorado, USA., Mandal R; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada., Wishart DS; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada., Wu H; School of Food Science and Nutrition, University of Leeds, Leeds, UK., Xia L; School of Food Science and Nutrition, University of Leeds, Leeds, UK., Routledge M; School of Food Science and Nutrition, University of Leeds, Leeds, UK.; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China., Gong YY; School of Food Science and Nutrition, University of Leeds, Leeds, UK., Espinosa C; Departments of Anesthesiology, Pain, and Perioperative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Aghaeepour N; Departments of Anesthesiology, Pain, and Perioperative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Liu J; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA., Houpt E; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA., Lawley TD; Wellcome Sanger Institute, Hinxton, UK., Browne H; Wellcome Sanger Institute, Hinxton, UK., Shao Y; Wellcome Sanger Institute, Hinxton, UK., Rwigi D; The Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya., Kariuki K; The Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya., Kaburu T; The Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya., Uhlig HH; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Department of Paediatrics and Biomedical Research Centre, University of Oxford, Oxford, UK., Gartner L; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK., Jones K; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Gastroenterology Department, Great Ormond Street Hospital for Children, London, UK., Koulman A; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, Cambridge, UK., Walson J; Global Health and Epidemiology, University of Washington, Seattle, Seattle, USA., Berkley J; The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

Publikováno v: Gates open research [Gates Open Res] 2022 Nov 03; Vol. 6, pp. 77. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).