Automated Large-Scale Production of Paclitaxel Loaded Mesenchymal Stromal Cells for Cell Therapy Applications

Autor: Daniela Lisini, Sara Nava, Simona Frigerio, Simona Pogliani, Guido Maronati, Angela Marcianti, Valentina Coccè, Gianpietro Bondiolotti, Loredana Cavicchini, Francesca Paino, Francesco Petrella, Giulio Alessandri, Eugenio A. Parati, Augusto Pessina

Publikováno v: Pharmaceutics, Vol 12, Iss 5, p 411 (2020)

Mesenchymal stromal cells (MSCs) prepared as advanced therapies medicinal products (ATMPs) have been widely used for the treatment of different diseases. The latest developments concern the possibility to use MSCs as carrier of molecules, including c

Externí odkaz: https://doaj.org/article/ca4a207a0b884c0aa0509828ed64cfc9

Human Olfactory Bulb Neural Stem Cells (Hu-OBNSCs) Can Be Loaded with Paclitaxel and Used to Inhibit Glioblastoma Cell Growth

Autor: Hany E. Marei, Patrizia Casalbore, Asmaa Althani, Valentina Coccè, Carlo Cenciarelli, Giulio Alessandri, Anna T. Brini, Eugenio Parati, Gianpietro Bondiolotti, Augusto Pessina

Publikováno v: Pharmaceutics, Vol 11, Iss 1, p 45 (2019)

Exploitation of the potential ability of human olfactory bulb (hOB) cells to carry, release, and deliver an effective, targeted anticancer therapy within the central nervous system (CNS) milieu remains elusive. Previous studies have demonstrated the

Externí odkaz: https://doaj.org/article/ee0672c1bf854d1cb87652526989f0dc

Paclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs-TRAIL) Increases Antitumor Efficacy of Their Secretome

Autor: Giampietro Farronato, Gianpietro Bondiolotti, Francesca Paino, Valentina Coccè, Augusto Pessina, Valeria Sordi, Eugenio Parati, Aldo Bruno Giannì, Giulio Alessandri, Francesco Petrella, Francesca Sisto, Loredana Cavicchini, Arianna Bonomi

Publikováno v: Current cancer drug targets.

Background: Adipose tissue-derived MSCs engineered with the tumor necrosis factor- related apoptosis-inducing ligand protein (MSCs-TRAIL) have significant anticancer activity. MSCs, without any genetic modifications, exposed to high doses of chemothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a93767260154b23f9689d701435b5ce
https://pubmed.ncbi.nlm.nih.gov/33200709

Human Olfactory Bulb Neural Stem Cells (Hu-OBNSCs) Can Be Loaded with Paclitaxel and Used to Inhibit Glioblastoma Cell Growth

Autor: Hany E. Marei 1, Patrizia Casalbore 2, Asmaa Althani 3, Valentina Coccè 4, Carlo Cenciarelli 5, Giulio Alessandri 6, Anna T. Brini 4, 7, Eugenio Parati 6, Gianpietro Bondiolotti 8, Augusto Pessina 4

Publikováno v: Pharmaceutics 11 (1) (2019). doi:10.3390/pharmaceutics11010045
info:cnr-pdr/source/autori:Hany E. Marei 1,+,*, Patrizia Casalbore 2,+, Asmaa Althani 3, Valentina Coccè 4, Carlo Cenciarelli 5, Giulio Alessandri 6, Anna T. Brini 4,7, Eugenio Parati 6, Gianpietro Bondiolotti 8 and Augusto Pessina 4/titolo:Human Olfactory Bulb Neural Stem Cells (Hu-OBNSCs) Can Be Loaded with Paclitaxel and Used to Inhibit Glioblastoma Cell Growth/doi:10.3390%2Fpharmaceutics11010045/rivista:Pharmaceutics/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:11 (1)
Pharmaceutics
Volume 11
Issue 1
Pharmaceutics, Vol 11, Iss 1, p 45 (2019)

Exploitation of the potential ability of human olfactory bulb (hOB) cells to carry, release, and deliver an effective, targeted anticancer therapy within the central nervous system (CNS) milieu remains elusive. Previous studies have demonstrated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dabf3724585c11e5a81b3c2e6460275
https://publications.cnr.it/doc/398491

Microfragmented human fat tissue is a natural scaffold for drug delivery: Potential application in cancer chemotherapy

Autor: Eugenio Parati, Anna T. Brini, Bianca Pollo, Mirco Ponzoni, Laura Gatti, Carlo Tremolada, Francesco Restelli, Fabio Pastorino, Augusto Pessina, Valentina Coccè, Gianpietro Bondiolotti, Angiola Berenzi, Giulio Alessandri, Michele Dei Cas, Rita Paroni

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 302

Localization of chemotherapy at the tumor site can improve therapeutic efficacy and reduce systemic toxicity. In previous studies we have shown that mesenchymal stromal cells (MSCs) isolated from bone marrow or adipose tissue can be loaded with the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ebc423a35d71c9fab772603f00c74f
https://pubmed.ncbi.nlm.nih.gov/30890444