Zobrazeno 1 - 10
of 469
pro vyhledávání: '"Gianpietro, Dotti"'
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human natural killer T cells (NKTs) are innate-like T lymphocytes increasingly used for cancer immunotherapy. Here we show that human NKTs expressing the pro-inflammatory cytokine interleukin-12 (IL-12) undergo extensive and sustained molecu
Externí odkaz:
https://doaj.org/article/a48e168e6afd41a0a78d021d474cf617
Autor:
Lidia Giraudo, Giulia Cattaneo, Loretta Gammaitoni, Ilenia Iaia, Chiara Donini, Annamaria Massa, Maria Laura Centomo, Marco Basiricò, Elisa Vigna, Alberto Pisacane, Franco Picciotto, Enrico Berrino, Caterina Marchiò, Alessandra Merlini, Luca Paruzzo, Stefano Poletto, Daniela Caravelli, Andrea Michela Biolato, Valentina Bortolot, Elisa Landoni, Marco Ventin, Cristina R. Ferrone, Massimo Aglietta, Gianpietro Dotti, Valeria Leuci, Fabrizio Carnevale-Schianca, Dario Sangiolo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-13 (2023)
Abstract Background Even acknowledging the game-changing results achieved in the treatment of metastatic melanoma with the use of immune checkpoint inhibitors (ICI), a large proportion of patients (40–60%) still fail to respond or relapse due to th
Externí odkaz:
https://doaj.org/article/3eb42d63a9594f5d95b1ee9f44199df2
Autor:
Yufeng Wang, David L. Drum, Ruochuan Sun, Yida Zhang, Feng Chen, Fengfei Sun, Emre Dal, Ling Yu, Jingyu Jia, Shahrzad Arya, Lin Jia, Song Fan, Steven J. Isakoff, Allison M. Kehlmann, Gianpietro Dotti, Fubao Liu, Hui Zheng, Cristina R. Ferrone, Alphonse G. Taghian, Albert B. DeLeo, Marco Ventin, Giulia Cattaneo, Yongxiang Li, Youssef Jounaidi, Peigen Huang, Cristina Maccalli, Hanyu Zhang, Cheng Wang, Jibing Yang, Genevieve M. Boland, Ruslan I. Sadreyev, LaiPing Wong, Soldano Ferrone, Xinhui Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target antig
Externí odkaz:
https://doaj.org/article/cdd6a0e581e24892b09297cc99e43a32
Autor:
Andrea Biondi, Gianpietro Dotti, Alice Pievani, Marta Biondi, Sarah Tettamanti, Marta Serafini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Abstract
Externí odkaz:
https://doaj.org/article/202b57b4527d46eabfa5cf891656ed44
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/472487173e704ef3ad30fb9dddbe2c08
Autor:
Alex S. Woodell, Elisa Landoni, Alain Valdivia, Andrew Buckley, Edikan A. Ogunnaike, Gianpietro Dotti, Shawn D. Hingtgen
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 6, Pp n/a-n/a (2023)
Abstract Chimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell thera
Externí odkaz:
https://doaj.org/article/2703b17aad854d00917108d980cb7bf5
Autor:
Barbara Savoldo, Gianpietro Dotti, Allison M Deal, Jonathan S Serody, Christopher Dittus, Nicholas P Tschernia, Hillary Heiling, Catherine Cheng, Caroline Babinec, Megan Gonzalez, J Kaitlin Morrison, Anne W Beaven, William A Wood, Natalie S Grover
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Chimeric antigen receptor (CAR)-T cells targeting CD30 have demonstrated high response rates with durable remissions observed in a subset of patients with relapsed/refractory CD30+ hematologic malignancies, particularly classical Hodgkin lymphoma. Th
Externí odkaz:
https://doaj.org/article/37ff0a870b1541c7ae281d7f0e1e2333
Autor:
Hongxia Li, Emily B. Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S. Parker, Chad V. Pecot, Gianpietro Dotti, Hongwei Du
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. Here the authors design B7-H3 targeting CAR-T cells engineered to express the chemokine receptor CCR2b, and show improved accumulation in the brain and enh
Externí odkaz:
https://doaj.org/article/6b5527f7df4141638fa2ab38499267ce
Autor:
Zhichuan Zhu, Xin Zhou, Hongwei Du, Erica W. Cloer, Jiaming Zhang, Liu Mei, Ying Wang, Xianming Tan, Austin J. Hepperla, Jeremy M. Simon, Jeanette Gowen Cook, Michael B. Major, Gianpietro Dotti, Pengda Liu
Publikováno v:
Advanced Science, Vol 10, Iss 3, Pp n/a-n/a (2023)
Abstract STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis. However, if and how STING exerts innate immunity‐independent function
Externí odkaz:
https://doaj.org/article/796291b0707848dcb29d54fda077dfb1
Autor:
Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, R. Bryan Bell, Zhifeng Gu, Gianpietro Dotti, Zhen Gu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the ant
Externí odkaz:
https://doaj.org/article/608a4349715044a79d78a3f8c89aa2c6