Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Giannoula Lakka, Klement"'
Autor:
Giulia Pozzati, Jinrui Zhou, Hananel Hazan, Giannoula Lakka Klement, Hava T. Siegelmann, Jack A. Tuszynski, Edward A. Rietman
Publikováno v:
Onco, Vol 4, Iss 3, Pp 163-191 (2024)
Whole-genome sequencing has revealed that TP53, NOTCH1, ATM, SF3B1, BIRC3, ABL, NXF1, BCR, and ZAP70 are often mutated in CLL, but not consistently across all CLL patients. This paper employs a statistical thermodynamics approach in combination with
Externí odkaz:
https://doaj.org/article/cbb7a77e2b574368b5b57277c1b9f346
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14648 (2023)
One of the most important aspects of successful cancer therapy is the identification of a target protein for inhibition interaction. Conventionally, this consists of screening a panel of genes to assess which is mutated and then developing a small mo
Externí odkaz:
https://doaj.org/article/fd1c64cf0533448ca1fba409e686698c
Autor:
Michal Kýr, Giannoula Lakka Klement, Lenka Zdrazilova-Dubska, Regina Demlova, Dalibor Valik, Ondrej Slaby, Irene Slavc, Jaroslav Sterba
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/5d8a8e190d794418846f582691ec283b
Autor:
Kristyna Polaskova, Tomas Merta, Alexandra Martincekova, Danica Zapletalova, Michal Kyr, Pavel Mazanek, Zdenka Krenova, Peter Mudry, Marta Jezova, Jiri Tuma, Jarmila Skotakova, Ivana Cervinkova, Dalibor Valik, Lenka Zdrazilova-Dubska, Hana Noskova, Karol Pal, Ondrej Slaby, Pavel Fabian, Sarka Kozakova, Jakub Neradil, Renata Veselska, Veronika Kanderova, Ondrej Hrusak, Tomas Freiberger, Giannoula Lakka Klement, Jaroslav Sterba
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
In order to identify reasons for treatment failures when using targeted therapies, we have analyzed the comprehensive molecular profiles of three relapsed, poor-prognosis Burkitt lymphoma cases. All three cases had resembling clinical presentation an
Externí odkaz:
https://doaj.org/article/5c281799cb3e41e29ab698bc35a5380e
Autor:
Elizabeth J Brant, Edward A Rietman, Giannoula Lakka Klement, Marco Cavaglia, Jack A Tuszynski
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0226883 (2020)
We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associate
Externí odkaz:
https://doaj.org/article/0274190597874c13857de6bb4f6c1832
Autor:
Michal Kyr, Kristyna Polaskova, Zuzana Kuttnerova, Tomas Merta, Jakub Neradil, Jitka Berkovcova, Ondrej Horky, Marta Jezova, Renata Veselska, Giannoula Lakka Klement, Dalibor Valik, Jaroslav Sterba
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Introduction: The individualization of treatment is attractive, especially in children with high-risk cancer. In such a rare and very heterogeneous group of diseases, large population-based clinical randomized trials are not feasible without internat
Externí odkaz:
https://doaj.org/article/86696cb98eda4de6be30002db1ea2e5d
Autor:
Michael Keegan, Hava T. Siegelmann, Edward A. Rietman, Giannoula Lakka Klement, Jack A. Tuszynski
Publikováno v:
BioMedInformatics; Volume 1; Issue 3; Pages: 201-210
Modern network science has been used to reveal new and often fundamental aspects of brain network organization in physiological as well as pathological conditions. As a consequence, these discoveries, which relate to network hierarchy, hubs and netwo
Autor:
Petra Pokorna, Giannoula Lakka Klement, Alzbeta Vasikova, Veronika Kanderova, Marta Jezova, Kristyna Noskova, Peter Mudry, Michal Kyr, Tomas Merta, Viera Bajciova, Zdenka Krenova, Hana Palova, Dalibor Valik, Lenka Zdrazilova Dubska, Ondrej Slaby, Jaroslav Sterba
Publikováno v:
JCO Precision Oncology.
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166655 (2016)
Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors. These regulators are released from platelet clots formed at the sites of activated endothelium in a
Externí odkaz:
https://doaj.org/article/31230a4ba1c0469eaadf061494c02901
Autor:
Giannoula Lakka Klement, David eGoukassian, Lynn eHlatky, Joseph eCarrozza, James P. Morgan, Xinhua eYan
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
The HER2-PI3K pathway is the one of the most mutated pathways in cancer. Several drugs targeting the major kinases of this pathway have been approved by the Food and Drug Administration and many are being tested in clinical trials for the treatment o
Externí odkaz:
https://doaj.org/article/15c15c1fea1644898103ccc2723b487c