Personalized therapy design for systemic lupus erythematosus based on the analysis of protein-protein interaction networks

Autor: Jack A. Tuszynski, Elizabeth J. Brant, Giannoula Klement, Edward A. Rietman, Marco Cavaglià

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0226883 (2020)

We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f49138aa30c4deddea698bfeb06076
https://pubmed.ncbi.nlm.nih.gov/32191711

Klippel-Trenauney syndrome with axillary hyperhidrosis

Autor: Yeun Jina Lim, Shiu-chung Au, David Rosmarin, Giannoula Klement

Publikováno v: Lim, Yeun Jina; Rosmarin, David; Klement, Giannoula; & Au, Shiu-chung. (2017). Klippel-Trenauney syndrome with axillary hyperhidrosis. Dermatology Online Journal, 23(6). Retrieved from: http://www.escholarship.org/uc/item/9448f90f

Klippel-Trenaunay syndrome (KTS) is a rare, clinically variable congenital disorder involving capillary malformations, soft tissue or bone hypertrophy, and venous malformations or varicose veins. We report a 28-year-old man who presented with a hyper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9100ea5a14b7d63ec6f8c4a8f8cd7b5
https://pubmed.ncbi.nlm.nih.gov/28633736

Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition

Autor: Giannoula Klement, Olga Dashevsky, Oliver Dodd, Abdo Abou-Slaybi, Irina Kareva

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 12, p e0166655 (2016)
PLoS

Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors. These regulators are released from platelet clots formed at the sites of activated endothelium in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b9954814fbda113bf1fe1fe1cf3fa9
http://europepmc.org/articles/PMC5147849

Thermodynamic measures of cancer: Gibbs free energy and entropy of protein–protein interactions

Autor: Edward A. Rietman, Jack A. Tuszynski, John Platig, Giannoula Klement

Thermodynamics is an important driving factor for chemical processes and for life. Earlier work has shown that each cancer has its own molecular signaling network that supports its life cycle and that different cancers have different thermodynamic en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85614bec4bd53e029ab2ca26afab936a
https://europepmc.org/articles/PMC4942417/

Future paradigms for precision oncology

Autor: Ondrej Slaby, Ali Hashemi, Paolo Carmassi, Csongor Kiss, Leos Kren, Edward A. Rietman, Giannoula Klement, A Kolenova, Jiri Tuma, Irene Slavc, Peter Múdry, Tina Roffidal, Nicolas André, Knarik Arkun, Gabor G. Kovacs, Koen Norga, Dobrin Konstantinov, Henk van den Berg, Jarmila Skotáková, Dalibor Valík, Christos Klement, Pavel Mazánek, Jaroslav Sterba

Publikováno v: Oncotarget

Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral and intra-tumoral variability. Individual tumors have unique profiles, and these molecular signatures make the use of traditional histology-based treatments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1201639880c816892ac1e9731ed96c96