Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Giannina Descalzi"'
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Chronic pain is associated with long term plasticity of nociceptive pathways in the central nervous system. Astrocytes can profoundly affect synaptic function and increasing evidence has highlighted how altered astrocyte activity may contribute to th
Externí odkaz:
https://doaj.org/article/8bba54cfab8244f8b420e002cfecfbaa
Autor:
Hiroki Toyoda, Xiang-Yao Li, Long-Jun Wu, Ming-Gao Zhao, Giannina Descalzi, Tao Chen, Kohei Koga, Min Zhuo
Publikováno v:
Neural Plasticity, Vol 2011 (2011)
The amygdala is known to be a critical brain region for emotional fear. It is believed that synaptic plasticity within the amygdala is the cellular basis of fear memory. Recent studies demonstrate that cortical areas such as the prefrontal cortex (PF
Externí odkaz:
https://doaj.org/article/730d84b4d55f4e87a2a98015a2b24acf
Autor:
Giannina Descalzi
Publikováno v:
Neurosci Bull
Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Communications Biology
Communications Biology
Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally
Publikováno v:
The Journal of Neuroscience. 38:1015-1029
Autism spectrum disorder (ASD) is a developmental disability characterized by impairments in social interaction and repetitive behavior, and is also associated with cognitive deficits. There is no current treatment that can ameliorate most of the ASD
Publikováno v:
Glia. 66:1244-1262
Memory, the ability to retain learned information, is necessary for survival. Thus far, molecular and cellular investigations of memory formation and storage have mainly focused on neuronal mechanisms. In addition to neurons, however, the brain compr
Autor:
Giannina Descalzi, Minoru Narita, Toshikazu Ushijima, Eric J. Nestler, Daigo Ikegami, Venetia Zachariou
Publikováno v:
Trends in Neurosciences. 38:237-246
Neuropathic and inflammatory pain promote a large number of persisting adaptations at the cellular and molecular level, allowing tissue or nerve damage, even if only transient, to elicit changes in cells that contribute to the development of chronic
Autor:
Giannina Descalzi, Sevasti Gaspari, Vasiliki Mitsi, Kleopatra Avrampou, Immanuel Purushothaman, Yong-Hwee E. Loh, Li Shen, Venetia Zachariou
Publikováno v:
Science Signaling. 10
Neuropathic pain is a complex chronic condition characterized by a wide range of sensory, cognitive, and affective symptoms. A large percentage of neuropathic pain patients are also afflicted with depression and anxiety disorders – a pattern that i
Autor:
Xiao Bin He, Le Shi Zhang, Zhijian Zhang, Jian Wang, Min Zhuo, Giannina Descalzi, Xin Qin, Yun-Qing Li, Shuang Qiu, Kohei Koga, Fuqiang Xu, Richard L. Huganir, Ji Hu, Feng Wei, Tao Chen
Publikováno v:
Molecular Pain
Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. In the anterior cingulate cortex (ACC), postsynaptic recruitment or modification of AMPA receptor (AMPAR) GluA1 contribute to the exp
Publikováno v:
Molecular Pain
Molecular Pain, Vol 8, Iss 1, p 15 (2012)
Molecular Pain, Vol 8, Iss 1, p 15 (2012)
Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play cri