Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gianni Sorarú"'
Autor:
Lorenzo Blasi, Daniele Sabbatini, Andrea Fortuna, Giorgia Querin, Ilaria Martinelli, Sara Vianello, Cinzia Bertolin, Davide Pareyson, Maria Pennuto, Elena Pegoraro, Luca Bello, Gianni Sorarù
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Serum creatinine has been indicated as a potential marker of motor function in SBMA and results form previous longitudinal studies pointed to its decline over time. This is a longitudinal retrospective study investigating creatinine changes
Externí odkaz:
https://doaj.org/article/235f22822deb4df9bceedd58a3147aac
Autor:
Jessica Mandrioli, Roberto D’Amico, Elisabetta Zucchi, Sara De Biasi, Federico Banchelli, Ilaria Martinelli, Cecilia Simonini, Domenico Lo Tartaro, Roberto Vicini, Nicola Fini, Giulia Gianferrari, Marcello Pinti, Christian Lunetta, Francesca Gerardi, Claudia Tarlarini, Letizia Mazzini, Fabiola De Marchi, Ada Scognamiglio, Gianni Sorarù, Andrea Fortuna, Giuseppe Lauria, Eleonora Dalla Bella, Claudia Caponnetto, Giuseppe Meo, Adriano Chio, Andrea Calvo, Andrea Cossarizza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, do
Externí odkaz:
https://doaj.org/article/b047af166d3e4b93aacae7ef3e501443
Autor:
Cassandra Margotta, Paola Fabbrizio, Marco Ceccanti, Chiara Cambieri, Gabriele Ruffolo, Jessica D’Agostino, Maria Chiara Trolese, Pierangelo Cifelli, Veronica Alfano, Christian Laurini, Silvia Scaricamazza, Alberto Ferri, Gianni Sorarù, Eleonora Palma, Maurizio Inghilleri, Caterina Bendotti, Giovanni Nardo
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-21 (2023)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic clinical trial failure. Transgenic SOD1G93A mice on C57 or 129Sv background have a slow and fa
Externí odkaz:
https://doaj.org/article/7192823fbb83411c8da66307bb56e490
Autor:
Ramachandran Prakasam, Angela Bonadiman, Roberta Andreotti, Emanuela Zuccaro, Davide Dalfovo, Caterina Marchioretti, Debasmita Tripathy, Gianluca Petris, Eric N. Anderson, Alice Migazzi, Laura Tosatto, Anna Cereseto, Elena Battaglioli, Gianni Sorarù, Wooi Fang Lim, Carlo Rinaldi, Fabio Sambataro, Naemeh Pourshafie, Christopher Grunseich, Alessandro Romanel, Udai Bhan Pandey, Andrea Contestabile, Giuseppe Ronzitti, Manuela Basso, Maria Pennuto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Here, Prakasam and colleagues show that polyQ-expanded androgen receptor toxicity can be attenuated using artificial miRNAs targeting Lsd1 and Prmt6, two AR-co-activators overexpressed in an androgen-dependent manner specifically in skeletal muscle,
Externí odkaz:
https://doaj.org/article/9fd52a5a537f405caa90331491bb84a3
Autor:
Caterina Marchioretti, Giulia Zanetti, Marco Pirazzini, Gaia Gherardi, Leonardo Nogara, Roberta Andreotti, Paolo Martini, Lorenzo Marcucci, Marta Canato, Samir R. Nath, Emanuela Zuccaro, Mathilde Chivet, Cristina Mammucari, Marco Pacifici, Anna Raffaello, Rosario Rizzuto, Andrea Mattarei, Maria A. Desbats, Leonardo Salviati, Aram Megighian, Gianni Sorarù, Elena Pegoraro, Elisa Belluzzi, Assunta Pozzuoli, Carlo Biz, Pietro Ruggieri, Chiara Romualdi, Andrew P. Lieberman, Gopal J. Babu, Marco Sandri, Bert Blaauw, Manuela Basso, Maria Pennuto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Marchioretti and colleagues show that in the skeletal muscle of SBMA mice and patients there is an early, but reversible alteration of expression of genes involved in muscle contraction and of mitochondrial respiration, followed by accumulation of ca
Externí odkaz:
https://doaj.org/article/82a8527dca0543cd91761ed8387c3654
Autor:
Antonio Mazzaro, Veronica Vita, Marco Ronfini, Irene Casola, Arianna Klein, Gabriella Dobrowolny, Gianni Sorarù, Antonio Musarò, Marco Mongillo, Tania Zaglia
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Rationale: The anatomical substrate of skeletal muscle autonomic innervation has remained underappreciated since it was described many decades ago. As such, the structural and functional features of muscle sympathetic innervation are largely undeterm
Externí odkaz:
https://doaj.org/article/41261813587d47b7a39ec443bb61dd24
Autor:
Alberto Terrin, Luca Bello, Maria Lucia Valentino, Leonardo Caporali, Gianni Sorarù, Valerio Carelli, Ferdinando Maggioni, Massimo Zeviani, Elena Pegoraro
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Recent scientific evidence suggests a link between migraine and brain energy metabolism. In fact, migraine is frequently observed in mitochondrial disorders. We studied 46 patients affected by mitochondrial disorders, through a headache-focu
Externí odkaz:
https://doaj.org/article/39b0a8fd519b467686fff36895d8a90a
Autor:
Cassandra Margotta, Paola Fabbrizio, Marco Ceccanti, Chiara Cambieri, Gabriele Rufolo, Jessica D’Agostino, Maria Chiara Trolese, Pierangelo Cifelli, Veronica Alfano, Christian Laurini, Silvia Scaricamazza, Alberto Ferri, Gianni Sorarù, Eleonora Palma, Maurizio Inghilleri, Caterina Bendotti, Giovanni Nardo
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/ea3a4bf8d6a44d7b8b71fae4f1a64a4e
Autor:
Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorarù, Christian Lunetta, Andrea Calvo, Adriano Chiò, Gabriele Mora, Maria Pennuto, Alessandro Quattrone, Francesco Rinaldi, Vito Giuseppe D’Agostino, Manuela Basso, Valentina Bonetto
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-21 (2021)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an urgent need to identify biomarkers to tackle the disease’s complexity and
Externí odkaz:
https://doaj.org/article/c1ded2cb5e844a29a6fd916295a220b1
Autor:
Daniele Sabbatini, Flavia Raggi, Susanna Ruggero, Mara Seguso, Jessica Mandrioli, Annachiara Cagnin, Chiara Briani, Elisabetta Toffanin, Matteo Gizzi, Andrea Fortuna, Luca Bello, Elena Pegoraro, Giulia Musso, Gianni Sorarù
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1750-1754 (2021)
Abstract Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neuro
Externí odkaz:
https://doaj.org/article/f63d61156e0248d48af282916ff6af60