Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Gianni Monaco"'
Autor:
Brian S. White, Aurélien de Reyniès, Aaron M. Newman, Joshua J. Waterfall, Andrew Lamb, Florent Petitprez, Yating Lin, Rongshan Yu, Martin E. Guerrero-Gimenez, Sergii Domanskyi, Gianni Monaco, Verena Chung, Jineta Banerjee, Daniel Derrick, Alberto Valdeolivas, Haojun Li, Xu Xiao, Shun Wang, Frank Zheng, Wenxian Yang, Carlos A. Catania, Benjamin J. Lang, Thomas J. Bertus, Carlo Piermarocchi, Francesca P. Caruso, Michele Ceccarelli, Thomas Yu, Xindi Guo, Julie Bletz, John Coller, Holden Maecker, Caroline Duault, Vida Shokoohi, Shailja Patel, Joanna E. Liliental, Stockard Simon, Tumor Deconvolution DREAM Challenge consortium, Julio Saez-Rodriguez, Laura M. Heiser, Justin Guinney, Andrew J. Gentles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using in vitro and in
Externí odkaz:
https://doaj.org/article/fbdd2912b0694dcb86f190414734e1ac
Autor:
Mike Mason, Óscar Lapuente-Santana, Anni S. Halkola, Wenyu Wang, Raghvendra Mall, Xu Xiao, Jacob Kaufman, Jingxin Fu, Jacob Pfeil, Jineta Banerjee, Verena Chung, Han Chang, Scott D. Chasalow, Hung Ying Lin, Rongrong Chai, Thomas Yu, Francesca Finotello, Tuomas Mirtti, Mikko I. Mäyränpää, Jie Bao, Emmy W. Verschuren, Eiman I. Ahmed, Michele Ceccarelli, Lance D. Miller, Gianni Monaco, Wouter R. L. Hendrickx, Shimaa Sherif, Lin Yang, Ming Tang, Shengqing Stan Gu, Wubing Zhang, Yi Zhang, Zexian Zeng, Avinash Das Sahu, Yang Liu, Wenxian Yang, Davide Bedognetti, Jing Tang, Federica Eduati, Teemu D. Laajala, William J. Geese, Justin Guinney, Joseph D. Szustakowski, Benjamin G. Vincent, David P. Carbone
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti–PD-1 Response Prediction DREAM Challenge, a crowdsourc
Externí odkaz:
https://doaj.org/article/c3635bd5bd234a2da3cffc46f246670f
Autor:
Fabian Hersperger, Tim Meyring, Pia Weber, Chintan Chhatbar, Gianni Monaco, Marc S Dionne, Katrin Paeschke, Marco Prinz, Olaf Groß, Anne-Kathrin Classen, Katrin Kierdorf
Publikováno v:
eLife, Vol 12 (2024)
Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue re
Externí odkaz:
https://doaj.org/article/73eb2793298442e9a0c9ec15b7293262
Autor:
Daniela C. Ivan, Kristina Carolin Berve, Sabrina Walthert, Gianni Monaco, Katharina Borst, Elisa Bouillet, Filipa Ferreira, Henry Lee, Jasmin Steudler, Thorsten Buch, Marco Prinz, Britta Engelhardt, Giuseppe Locatelli
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the central nervous system (CNS) and regulates neuronal survival and myelination in the adult CNS. In neuroinflammatory conditions including multiple scler
Externí odkaz:
https://doaj.org/article/a963821709be460bb9d9a0e0b95caaad
Autor:
Anie P. Masilamani, Nathalie Huber, Constanze Nagl, Viviane Dettmer-Monaco, Gianni Monaco, Isis Wolf, Susanne Schultze-Seemann, Sanaz Taromi, Christian Gratzke, Hendrik Fuchs, Philipp Wolf
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface structure and a cytotoxic domain that kills the cell after cytosolic uptake. Pseudomonas Exotoxin A (PE) based immunotoxins directed against a variety of t
Externí odkaz:
https://doaj.org/article/4b615ad456c045f1976d8485e0089693
Autor:
Gianni Monaco, Ashkan Khavaran, Adrià Dalmau Gasull, Jonathan Cahueau, Martin Diebold, Chintan Chhatbar, Mirco Friedrich, Dieter Henrik Heiland, Roman Sankowski
Publikováno v:
Cancers, Vol 14, Iss 19, p 4915 (2022)
Glioblastomas are the most common primary brain tumors. Despite extensive clinical and molecular insights into these tumors, the prognosis remains dismal. While targeted immunotherapies have shown remarkable success across different non-brain tumor e
Externí odkaz:
https://doaj.org/article/a1ac873a46e241758082480aa4fad23b
Autor:
Weili Xu, Gianni Monaco, Eleanor Huijin Wong, Wilson Lek Wen Tan, Hassen Kared, Yannick Simoni, Shu Wen Tan, Wilson Zhi Yong How, Crystal Tze Ying Tan, Bernett Teck Kwong Lee, Daniel Carbajo, Srinivasan K.G., Ivy Chay Huang Low, Esther Wing Hei Mok, Shihui Foo, Josephine Lum, Hong Liang Tey, Wee Ping Tan, Michael Poidinger, Evan Newell, Tze Pin Ng, Roger Foo, Arne N. Akbar, Tamas Fülöp, Anis Larbi
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 44-58 (2019)
Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T
Externí odkaz:
https://doaj.org/article/1de8ee1204604eb2a6fbd69c78a8cfae
Autor:
Ingram Iaccarino, Fatme Mourtada, Sarah Reinke, Paurnima Patil, Gero Doose, Gianni Monaco, Steve Hoffmann, Reiner Siebert, Wolfram Klapper
Publikováno v:
Non-Coding RNA, Vol 8, Iss 3, p 40 (2022)
Successful immunotherapy in both solid tumors and in hematological malignancies relies on the ability of T lymphocytes to infiltrate the cancer tissue and mount an immune response against the tumor. Biomarkers able to discern the amount and the types
Externí odkaz:
https://doaj.org/article/752e73765a5b4e4f8b3c54917a477736
Autor:
Abhishek S. Kashyap, Laura Fernandez-Rodriguez, Yun Zhao, Gianni Monaco, Marcel P. Trefny, Naohiro Yoshida, Kea Martin, Ashwani Sharma, Natacha Olieric, Pankaj Shah, Michal Stanczak, Nicole Kirchhammer, Sung-Moo Park, Sebastien Wieckowski, Heinz Laubli, Rachid Zagani, Benjamin Kasenda, Michel O. Steinmetz, Hans-Christian Reinecker, Alfred Zippelius
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3367-3380.e8 (2019)
Summary: Dendritic cell (DC) activation is a critical step for anti-tumor T cell responses. Certain chemotherapeutics can influence DC function. Here we demonstrate that chemotherapy capable of microtubule destabilization has direct effects on DC fun
Externí odkaz:
https://doaj.org/article/21a0d97cff3b46a0a90aae9154512253
Autor:
Gianni Monaco, Bernett Lee, Weili Xu, Seri Mustafah, You Yi Hwang, Christophe Carré, Nicolas Burdin, Lucian Visan, Michele Ceccarelli, Michael Poidinger, Alfred Zippelius, João Pedro de Magalhães, Anis Larbi
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1627-1640.e7 (2019)
Summary: The molecular characterization of immune subsets is important for designing effective strategies to understand and treat diseases. We characterized 29 immune cell types within the peripheral blood mononuclear cell (PBMC) fraction of healthy
Externí odkaz:
https://doaj.org/article/429bd0060ca44b7cb60c8cd0de283ded