Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gianni Mancini"'
Autor:
Luisa O. Schmitt, Antonella Blanco, Sheila V. Lima, Gianni Mancini, Natalia F. Mendes, Alexandra Latini, Joana M. Gaspar
Publikováno v:
Metabolites, Vol 14, Iss 3, p 161 (2024)
Consumption of high-fat diets (HFD) is associated with brain alterations, including changes in feeding behavior, cognitive decline, and dementia. Astrocytes play a role in HFD-induced neuroinflammation and brain dysfunction; however, this process is
Externí odkaz:
https://doaj.org/article/e09fbd19ab9e43b98920c34b2fedb836
Autor:
Victor Coelho, Luisa Bandeira Binder, Naiani Ferreira Marques, Leandra Celso Constantino, Gianni Mancini, Carla Inês Tasca
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1207 (2022)
Alzheimer’s disease (AD) is a progressive neurodegenerative illness responsible for cognitive impairment and dementia. Accumulation of amyloid-beta (Aβ) peptides in neurons and synapses causes cell metabolism to unbalance, and the production of re
Externí odkaz:
https://doaj.org/article/fc7b0e2bbb7547d7bd43a3b5d73d2879
Autor:
Cristine de Paula Nascimento-Castro, Elisa C. Winkelmann-Duarte, Gianni Mancini, Priscilla Gomes Welter, Evelini Plácido, Marcelo Farina, Joana Gil-Mohapel, Ana Lúcia S. Rodrigues, Andreza Fabro de Bem, Patricia S. Brocardo
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1433 (2022)
Huntington’s disease (HD) is a genetic neurodegenerative disease characterized by motor, psychiatric, and cognitive symptoms. Emerging evidence suggests that emotional and cognitive deficits seen in HD may be related to hippocampal dysfunction. We
Externí odkaz:
https://doaj.org/article/f76cc44072f5426a9693e92fe72a028b
Autor:
JADE DE OLIVEIRA, MARCOS R. STRALIOTTO, GIANNI MANCINI, CLAUDIA P. FIGUEIREDO, ANTÔNIO L. BRAGA, JOÃO B.R. TEIXEIRA, ANDREZA F. BEM
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 88, Iss 3 suppl, Pp 1953-1965
ABSTRACT Oxidation of low-density lipoprotein (LDL) has been strongly suggested to play a significant role in the pathogenesis of atherosclerosis. Thus, reducing LDL oxidation is a potential approach to decrease the risk of the atherosclerosis. Organ
Externí odkaz:
https://doaj.org/article/495a7ebb756e48b79114b0478bbf84c3
Publikováno v:
Molecular Neurobiology. 57:4187-4201
Amyloid-β (Aβ) peptides play a significant role in the pathogenesis of Alzheimer’s disease (AD). Neurotoxic effects promoted by Aβ peptides involve glutamate transmission impairment, decrease of neurotrophic factors, mitochondrial dysfunction, o
Autor:
Ana Ledo, Andreza Fabro de Bem, Cátia F. Lourenço, João Laranjinha, Cândida Dias, Gianni Mancini
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Background: Ample evidence from clinical and pre-clinical studies suggests mid-life hypercholesterolemia as a risk factor for developing Alzheimer's disease (AD) at a later age. Hypercholesterolemia induced by dietary habits can lead to vascular pert
Autor:
Alessandro de Souza Prestes, Jean Paul Kamdem, Nilda Vargas Barbosa, Matheus Mulling dos Santos, Gianni Mancini, Andreza Fabro de Bem, Luana Caroline da Silva
Publikováno v:
Chemico-biological interactions. 351
Methylglyoxal (MG) is a reactive metabolite derived from different physiological pathways. Its production can be harmful to cells via glycation reactions of lipids, DNA, and proteins. But, the effects of MG on mitochondrial functioning and bioenerget
Autor:
Roberta de Paula Martins, Mauricio P. Cunha, Daniele G. Machado, Andreza Fabro de Bem, Alcir Luiz Dafre, Alexandra Latini, Gianni Mancini, Ana Lúcia S. Rodrigues, Viviane Glaser
Publikováno v:
Pharmacology, Biochemistry, and Behavior
Voluntary wheel running is widely used as a physical activity (PA) model in rodents, but most studies investigate the beneficial effects of this intervention in socially isolated mice. Social isolation stress (SIS) is associated with vulnerability to
Publikováno v:
Molecular neurobiology. 57(10)
Amyloid-β (Aβ) peptides play a significant role in the pathogenesis of Alzheimer's disease (AD). Neurotoxic effects promoted by Aβ peptides involve glutamate transmission impairment, decrease of neurotrophic factors, mitochondrial dysfunction, oxi
Autor:
Guilherme de Sousa, Eduardo Luiz Gasnhar Moreira, Adriano Emanuel Machado, Andreza Fabro de Bem, Moacir S. Faria, Gianni Mancini
Publikováno v:
NeuroReport. 29:1140-1143
The present study evaluated the effects of hypercholesterolemia in response to conditioned aversive stimuli in mice. Specifically, (a) young (3 months old) and aged (24 months old) female C57Bl/6 mice were fed daily for 4 weeks with a standard rodent